John S. Ramsdell, Ph.D.

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Marine Biomedicine and Environmental Sciences | Faculty | John S. Ramsdell, Ph.D.

John S. Ramsdell, Ph.D.

Research Interest:
My laboratory investigates the toxicology of three algal toxins (domoic acid, ciguatoxin and brevetoxin) with an emphasis to identify populations most susceptible to these toxins and to monitor toxin exposure to predict adverse effects. A current theme in our toxicology research is to uncover the fetal basis of adult disease through identification of early life toxicity that becomes apparent later in life. Much of our work to assess exposure centers upon understanding the disposition of toxin in blood with current research focused on transport by lipoproteins, oxidative and conjugative metabolism and tissue distribution. Active research is also conducted to refine and implement methods to monitor toxins humans and marine animals.

Selected Publications:

1. Radwan FF and JS Ramsdell. 2008. Brevetoxin forms covalent DNA adducts in rat lung following intratracheal exposure. Environmental Health Perspectives 116, 930-936.

2. Hinton, M and JS Ramsdell. 2008. Brevetoxin in two planktivorous fishes after exposure to Karenia brevis: implications for food-web transfer to bottlenose dolphins. Marine Ecology Progress Series 356: 251–258.

3. Selwood AI, Ginkel R, Wilkins AL, Munday R, Ramsdell JS, Jensen DJ, Cooney JM and CO Miles. 2008. Semisynthesis of s-desoxybrevetoxin-B2 and brevetoxin-B2, and assessment of their acute toxicities. Chemical Research and Toxicology. (4):944-50.

4. Dechraoui MY, Rezvani AH, Gordon CJ, Levin ED and JS Ramsdell. 2008. Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: Relationship to blood ciguatoxin concentrations. Toxicology. 246:55-62.

5. Morey JS, Ryan JC, Bottein Dechraoui MY, Rezvani AH, Levin ED, Gordon CJ, Ramsdell JS, and FM Van Dolah FM. 2008. Liver genomic responses to ciguatoxin: Evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice. Toxicological Sciences 103:298-310.