Peter Van den Hurk, Ph.D.
My research interest can be summarized as a basic curiosity to find out how animals, and specifically fish, deal with environmental contaminants. Animals have developed ways to deal with unwanted compounds in their environment. Even before the human population explosion caused significant environmental pollution, animals were exposed to harmful “natural” compounds in their environment and diet, and detoxification pathways have evolved to neutralize and excrete these harmful compounds. I am interested in how these detoxification pathways work, and how they have evolved. Measurements of detoxification pathways can be used as biomarkers for exposure to and effects of toxicants. My research program has developed into a two pronged approach: investigating the basic science of detoxification enzymes and using these enzymes as biomarkers in environmental applications. Specific topics of research are:
1) Evolutionary history of sulfotransferases and glucuronosyltransferases
2) Biomarker responses in fish as predictors for population effects
3) Influence of chemical stress on protein excretion into bile
4) Toxicity of sulfonamides to estuarine fish species.
5) Heme metabolism in fish species
Selected Publications:1. Truman, P.A., Van den Hurk, P. (2007). A biomarker approach examining xenoestrogen exposure in bluegill in the Reedy River watershed, SC, USA. Environ. Monitor. Assessm. (submit.)
2. Van den Hurk, P., Wiley, F.E., Lavoie, E.T., Grasman, K.A., Bowerman, W.W. (2007) Activity patterns of biotransformation enzymes in juvenile chickens after in ovo dosage of PCB126. Comp. Biochem. Physiol. Part C 146:301-307.
3. Otter, R.R., Schreiber, E.S., Van den Hurk, P., Klaine, S.J. (2007) Use of biomarkers and chemical analysis to evaluate PAH and metal exposure in Micropterus salmoides. Ecotox. Environ. Safety (submitted).
4. Schreiber, E.S., Otter, R.R., Van den Hurk, P. (2006) A biomarker approach to measure biological effects of contaminant exposure in largemouth bass from Lake Conestee, SC, USA. Environ. Toxicol. Chem. 25: 1829-1835.
5. Van den Hurk, P. (2006) Bile fluorescence, heme oxygenase induction, and increased biliverdin excretion by mixtures of environmental toxicants. Aquat. Toxicol. 77: 202-209
|Peter Van den Hurk, Ph.D.|
|Assistant Professor, Dept. Biological Sciences|
Clemson University, Clemson SC
Ph.D., College of William and Mary