Frances M. Van Dolah, Ph.D.
Research Interest:My laboratory focuses on toxic marine phytoplankton and the impacts of the toxins they produce. We employ a wide array of cell biology, molecular biology, and functional genomics tools to study the mechanisms underlying the processes of harmful algal bloom formation. Current research focuses on the Florida red tide dinoflagellate, /Karenia brevis,/ with emphasis on the molecular mechanisms regulating growth, toxicity, and stress responses/adaptation of that allow this dinoflagellate to dominate the west Florida shelf for many months at a time. In addition, we study the impacts of algal toxins on the health of marine animals. We provide toxin analysis for marine mammal mortality events occurring in U.S. waters and use toxicogenomic approaches to investigate the consequences of algal toxin exposure in rodent models, marine mammals and humans.
Selected Publications: 1. Johnson, J.G., Morey, J.S., Beal, M., Ryan, J.C., Van Dolah, F.M. 2011. Transcriptome remodeling associated with chronological aging in the dinoflagellate, Karenia brevis. Marine Genomics doi: 10.1016/j.margen.2011.08.005
2. Morey, J.S., Monroe, E.A., Kinney, A.L., Beal, M., Johnson, J.G., Hitchcock, G.L., Van Dolah, F.M. 2011. Transcriptomic response of the Florida red tide dinoflagellate, Karenia brevis, to nitrogen and phosphorus depletion and addition. BMC Genomics 12:346
3. Brunelle S.A. and Van Dolah, F.M. 2011. Post-transcriptional regulation of S-phase genes in the dinoflagellate Karenia brevis. Journal of Eukaryotic Microbiology 58: 373-82.
4. Monroe, E.A., and Van Dolah F.M. 2010. Nuclear encoded, chloroplast localized polyketide synthases in the dinoflagellate Karenia brevis. J. Phycology 46:541-552
5. Ryan, J.C. Morey,J.S. Dechraoui, M-Y. B. Ramsdell J.S., and Van Dolah, F.M. 2010. Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response. BMC Neuroscience. 11:107
|Frances M. Van Dolah, Ph.D.|
National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research
Ph.D., Medical University of South Carolina