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 Marine Biomedicine and Environmental Sciences | MBES Students | Alexis Temkin

Alexis Temkin

Research Interest:
Broadly I’m interested in how the environment and our exposure to environmental contaminants affect human health. I have a specific interest in how fetal and early life exposure to compounds known as obesogens can impact adult onset of obesity. I plan to take a comparative biology approach to investigate this topic, using stem cells lines as a surrogate for fetal growth from the American alligator, pygmy sperm whale and human. I’m also interested in DNA methylation and how it may play a role in the obesogen mechanism of action.

Publications, Presentations, Posters & Meetings Attend:
Paliwal A.1, A. Temkin1, K. Kerkel, A. Yale, N. Drost, S. Lax, I. Yotova,  C. Nhan-Chang, C. Powell, A. Borczuk, A. Aviv, R. Wapner, X. Chen, P. Nagy, N. Schork, A. Torkamani, and B. Tycko. Fine-mapping and comparative anatomy of chromosomal domains with imprinted versus non-imprinted allele-specific DNA methylation. PLOS Genetics. Oct 2012. Submitted for review. 1The first two authors made equal contributions to this work.

Guzman E., M. Maher, A. Temkin, T. Pitts and A. Wright. Spongiatriol inhibits the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells. Marine Drugs. 2012. Submitted for review.

Chace C., D. Pang, C. Weng, A. Temkin, S. Lax, W. Silverman, W. Zigman, M. Ferin, J.H. Lee and B. Tycko. Schupf N. Variants in CYP17 and CYP19 Cytochrome P450 Genes are Associated with Onset of Alzheimer's Disease in Women with Down Syndrome. Journal of Alzheimer's Disease. ePub ahead of print. Nov 201 1

Kalac M., L. Scotto, E. Marchi, J. Amengual, V.E. Seshan, G. Bhagat, N. Ulahannan, V.V. L eshchenko, A.M. Temkin, S. Parekh, B.Tycko and O.A. O'Connor. HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL. Blood 201 1 118:5506-5516.

Abby Goodson

Alexis Temkin

Mentor: Dr. Demetri Spyropoulos

BA, Connecticut College 2010

Year Matriculated: 2012