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  • NC NM4R QBAR Core image

    The Quantitative Behavioral Assessment and Rehabilitation Core

    Steve Kautz, PhD, Director

  • NC NM4R BSTIM Core image

    The Brain Stimulation Core

    Mark S. George, MD, Director

  • NC NM4R Neuroimaging Core image

    The Neuroimaging Core

    Truman Brown, PhD, Director

Pilot Project Awards

National Center of Neuromodulation for Rehabilitation 2018-2019 Pilot Project Awardees


 

 

Stacey DeJong, Ph.D., PT 

University of Iowa, Dept. of Physical Therapy and Rehabilitation Science

Effects of Operant Up-conditioning of Motor Evoked Potentials on Corticospinal and Spinal Reflex Excitability in People with Wrist Flexor Hypertonia after Stroke

Paresis after stroke is associated with diminished corticospinal excitability and often results in loss of upper limb function.  This study expands the application of operant conditioning by examining whether people with stroke are able to increase wrist flexor motor evoked potentials elicited by transcranial magnetic stimulation.  We will quantify the effects of this neuromodulation strategy on cortical representations, spinal reflex excitability, and wrist motor control.

 

Stacey DeJong photo

Emily J. Fox, Ph.D., DPT, NCS

University of Florida, Dept. of Physical Therapy and Brooks Rehabilitation

and

David. J. Clark, ScD

University of Florida, Institute on Aging

Neuromodulation of Spinal Circuits to Enhance Practice-related Performance on a Complex Walking Task

This study evaluates excitatory neuromodulation of the spinal cord during walking to enhance practice-related gains in performance and retention on an obstacle walking task. If transcutaneous direct current stimulation (tsDCS) shows promise for improving practice effects, this study will provide the necessary data and justification for designing intervention trials that use spinal tsDCS an adjuvant to walking rehabilitation. The proposed intervention techniques are low cost and translatable to real-world settings, which enhances the potential impact of this work on the well-being of older adults.

 

 

 

 

David Clark photo

Bernadette Gillick, Ph.D., MSPT, PT

McKnight Land Grant Professor, Department of Rehabilitation Medicine, University of Minnesota Medical School

Comparing Two Montages of Transcranial Direct Current Stimulation in Pediatric Stroke

Neuromodulatory interventions such as tDCS have recently been studied in children with unilateral cerebral palsy to enhance movement function, with many studies applying inhibitory tDCS to the contralesional hemisphere to balance interhemispheric inhibition between hemisphere. However, the optimal tDCS montage to produce changes in cortical excitability has not been thoroughly investigated. Using a single application of tDCS, we will test the effects of two tDCS montages, cathodal contralesional or anodal ipsilesional, on the cortical excitability after-effects. This research will guide future large clinical intervention trials incorporating tailored applications of non-invasive neuromodulation.  Further study information is available here.

 
 
Bernadette Gillick photo

Dorothea Jenkins, M.D. 

Medical University of South Carolina, Pediatrics and Neonatology

Noninvasive Brain Stimulation to Improve Oromotor Function In Neonates 

Preterm infants and term infants who suffer birth asphyxia are at high risk for motor problems, such as learning to take feeds by mouth, and may have to have a gastrostomy tube surgically placed into their stomach to be able to feed well enough to go home. Even after significant brain injury, we know that pairing rehabilitative training and brain stimulation increases neuroplasticity by remodeling motor cortex, leading to improved motor skills.  As the first application of brain stimulation technology in human neonates, we will simultaneously deliver transcutaneous auricular vagus nerve stimulation with bottle feeding to boost motor cortical plasticity which may lead to better feeding.

Dorothea Jenkins photo

 

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