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Center on Aging


Publications by Center on Aging Faculty

Amella, E. J., Lawrence, J. F., & Gresle, S. O. (2005). Tube feeding: Prolonging life or death in vulnerable populations? Mortality, 10(1), 69 – 81.

DiMaria-Ghalili, R.A. & Amella, E. (2005). Nutrition in older adults. American Journal of Nursing, 105 (3), 52 – 62.

Amella, E. J. (2004). Presentation of illness in older adults. American Journal of Nursing, 104 (10), 40 – 51.

Amella, E. J. (2004) Feeding and hydration issues for older adults with dementia. Nursing Clinics of North America, 39(3), 607 - 623.

Hunter CL, Quintero EM, Gilstrap L, Bhat NR, Granholm A-C. 2004. Minocycline protects basal forebrain cholinergic neurons from mu p75-SAP immunotoxic lesioning. Eur J Neurosci 19:3305-3316.

Pawate S, Shen Q, Fan F, Bhat NR. 2004. Redox regulation of glial inflammatory
response to lipopolysaccharide and interferong. J Neurosci Res 77: 540-551.

Sambamurti K, Granholm A-C, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE. Cholesterol and Alzheimer’s Disease: Clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Current Drug Targets 5: 517-528, 2004.

Samuel JD, Jayanthi LD, Bhat NR, Ramamurti S. Pivotal role of p38 MAP kinase in the regulation of cocaine and antidepressant sensitive serotonin transporter in mid brain synaptosome. J. Neurosci 25:29-41, 2005.

Kovacich, J., Garrett, R., & Forti, E.M. (2005, accepted). New learning programs in cognitive vitality, Alzheimer’s disease and related dementias. Gerontology and Geriatrics Education.

Forti, E.M., & Koerber, M. (2005, in revision). Care management for older rural African Americans. The Gerontologist

Forti, E.M., & Briggs, E. (2005, March). Meeting oral health care needs in rural America. Policy Brief. NRHA Policy Board. [Online]

Phillips, D., Forti, E.M, Guidry, J., & Byas, K. (2004, July). National policy issue paper on HIV/AIDS in rural America: Disproportionate impact on minority and multicultural populations. NRHA Policy Board. Retrieved February 12, 2005, from

Forti, E.M., Dye, C, & Adler, G. (2005). Summit on Aging White Paper: Meeting elder needs with fewer resources in South Carolina. South Carolina Center for Gerontology, University of South Carolina.

Forti, E.M. (2004, December). South Carolina oral health action plan. SC DHEC, Office of Dental Health, Columbia, SC. (contributed)

Perweiler, E., Forti, EM, & Tumosan, N. (2004, December). National Association of Geriatric Education Centers (NAGEC). Policy Brief: Reauthorization of Title VII Programs. (requested by AAMC).

Quintero E.M., Willis L.M., Zaman V., Lee J., Boger H.A., Tomac A., Hoffer B.J., Strömberg I., Granholm A-Ch. GDNF is essential for neuronal survival in the locus coeruleus-hippocampal noradrenergic pathway Neuroscience 124: 137-146, 2004.

Hunter Ch., Bimonte-Nelson H.A., Nelson M., Eckman C.B., and Granholm A-Ch. Behavioral and neurobiological markers of Alzheimer’s disease in Ts65Dn mice: effects of estrogen. Neurobiol. Aging 25: 873-884, 2004.

Hunter C.L., Quintero E.M., Gilstrap L., Bhat N.R., and Granholm A-Ch. Minocycline protects basal forebrain cholinergic neurons from mu p75-SAP immunotoxic lesions. Eur.J. Neurosc. 19(12): 3305-3316, 2004.

Sambamurti K., Mintzer J., Granholm A-Ch., Haugabook S., Kindy M.S., Greig N., Lahiri D. Cholesterol and Alzheimer’s disease: Clinical and Experimental Models Suggest Interactions of Different Genetic, Dietary and Environmental Risk Factors. Current Drug Targets 5: 517-528, 2004.

Hunter C.L.,Bachman D., and Granholm A-Ch. Minocycline prevents cholinergic loss in a mouse model of Down’s syndrome. Annal. Neurol. 56: 675-688, 2004.

Bimonte-Nelson H.A., Nelson M.E., and Granholm A-Ch. Progesterone counteracts estrogen-induced increases in neurotrophins in the aged female rat brain. NeuroReport 15(17): 2659-2663, 2004.

Willis L., Quintero E.M., Nelson M., and Granholm A-Ch. Regulation of trophic factor expression by innervating target regions in intraocular double transplants. Cell Transplantation (in press), 2005.

Willis L., Bickford P.C., Zaman V., Moore A.B., and Granholm A-Ch. Blueberry extract enhances survival of intraocular hippocampal transplants. Cell Transplantation (in press), 2005.

Williams B., Nelson M.E., Granholm A-Ch., Coultrap S., Browning M., and Curtis M. Altered NGF response but not release in the aged septo-hippocampal cholinergic sytstem. Exp. Neurology (in press), 2005.

French, K.L., Granholm A-Ch., Moore A.B., Nelson M.E., and Bimonte-Nelson H.A. Chronic nicotine enhances performance as working memory load increase and lowers hippocampal NGF in aged female rats. J. Pharm. Exp. Ther. (submitted), 2005.

Paredes D., Granholm A-Ch., and Bickford P.C. Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat. Eur. J. Neurosci. (submitted), 2005.

Wessell AM, Weart CW. Eszopiclone (Lunesta) for Treatment of Transient and Chronic Insomnia (STEPS New Drug Review). American Family Physician 2005;71(12):2359.

Schwiesow SJ, Wessell AM, Steyer TE. Use of a modified dosing weight for heparin therapy in a morbidly obese patient. Annals of Pharmacotherapy 2005;39:753-6. (DOI 10.1345/aph.1E300.)

Arancio O, Zhang HP, Yu J, Chen X, Lin C, Trinchese F, Battaglia F, Yan SF, Stern A, Lue LF, Walker D, Roher A, Buttini M, Mucke L, Yi L, Kindy M, Hyslop P, Stern D, and Yan SD. RAGE Potentiates Aß-induced perturbation of neuronal function in transgenic mice, EMBO, 2004, 1-10.

Ertekin-Taner N, Ronald J, Feuk L, Prince J, Tucker M, Younkin L, Hella M, Jain S, Hackett A, Scanlin L, Kelly J, Kihiko-Ehman M, Neltner M, Hersh L, Kindy M, Markesbery W, Hutton M, Andrade M, Petersen RC, Graff-Radford N, Estus S, Brookes AJ, Younkin SG. Elevated amyloid {beta} protein (A{beta}42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Hum Mol Genet. 2005, 14:447-460.

Zhang L., Yu J, Kindy M. Does knockout of JNK3 gene provide a protective action in spinal cord injury of mice? International J. Emergency Critical Care Med. 2005, 2:497-503.

Suzuki S, Gerhold LM, Böttner M, Rau SW, Cruz CD, Yang E, Zhu H, Yu J, Cashion AB, Kindy MS, Merchenthaler I, Gage FH, Wise PM. Estradiol Enhances Neurogenesis After Ischemic Brain Injury:Roles of Estrogen Receptor a and b. Science, Submitted.

Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer J: Cholesterol and Alzheimer’s disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr Drug Targets. 2004. Aug; 5(6):517-28.

Nahas Z, Li X, Kozel FA, Mirski D, Memon M, Miller K, Yamanaka K, Anderson B, Chae JH, Bohning DE, Mintzer J, George MS: Safety and benefits of distance-adjusted prefrontal transcranial magnetic stimulation in depressed patients 55-75 years of age: A pilot study. Depress Anxiety. 2004; 19(4):249-56.

Mintzer JE, Muller JA, Switzer DE: A comparison of extrapyramidal symptoms in elderly patients treated with quetiapine or risperidone. Curr Medical Research and Opinion.2004 Sep; 20(9): 1483-1491.

Carter R, Rose DA, Palesch Y, Mintzer JE: Alzheimer’s Disease in the Family Practice Setting. Prim Care Companion J Clin Psychiatry 2004;6(6):234-238

Rosenberg PB, Onylike CU, Katz IR, Porsteinsson AP, Mintzer JE, Schneider LS, Rabins PV, Meinert CL, Martin BK, Lyketsos CB: Clinical application of operationalized criteria for “Depression of Alzheimer Disease.” Int J Geriatric Psychiatry 2005; 20(2):119-27.

Cohen-Mansfield J, Mintzer JE: Time for Change: the role of nonpharmacological interventions in treating behavior problems in nursing home residents with dementia. Alzheimer Dis Assoc Disor 2005 January/February/March; 19(1):37-40.

In Press:

Krishnan KR, Charles HC, Doraiswamy PM, Mintzer JE, et al: Potential neurostablising effects of donepezil in patients with Alzheimer’s disease: measurement of N-acetylaspartate levels using proton magnetic resonance spectroscope in a randomized, placebo-controlled trial.

Mintzer J, Aparicio-Cabrera A, Gomez L, Coronado L: Galantamine in the Treatment of Dementia in Hispanic Patients: An Effectiveness Multicenter Open Label Study.

Mintzer J, Burns A, Lilienfeld S, Kershaw P: Safety of Galantamine and Atypical Antipsychotics in Mild-to-Moderate Alzheimer’s Disease.

Kennedy GJ, Ferri CV, Mintzer J, Koss E, Mittelman MS, Teri L, Burgio LD, Beck CK, Cohen-Mansfield J and Camp C: Advancing the Research Methodology for Non-Pharmacologic Interventions in Dementia.

Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B. (2004) Defects in cell growth regulation by c18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. JBC.
279(43):44311-9. Epub 2004 Aug 17.

Argraves, K.A., Wilkerson, B.A., Argraves, W.S., Fleming, P.A., Obeid, L.M., and Drake, C.J.. (2004) Sphingosine-1-Phosphate Signaling Promotes Critical Migratory Events in Vasculogenesis. JBC. 10.1074.

Yamanaka, M., Shegogue, D., Pei, H., Bielawska, A., Bielawski, J., Pettus, B., Hannun, Y., Obeid, L., and Trojanowska, M. (2004) Sphingosine Kinase 1 (SPHK1) is induced by TGF-b and mediates TIMP-1 upregulation. JBC. 10.1074.

Birbes, H., Luberto, C., Hsu, T., El Bawab, S., Hannun , Y.A., and Obeid, L.M. (2004) A Mitochondrial Pool of Sphingomyelin is Involved in TNFa-induced Apoptosis. BJ immediate publication 10/29/04.

Rossi M.J., Sundararaj K., Koybasi S., Phillips M.S., Szulc Z.M., Bielawska A, Day T.A., Obeid L.M., Hannun Y.A, and Ogretmen B. (2004) Inhibition of Growth and Telomerase Activity by Novel Cationic Ceramide Analogs with High Solubility in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells. Otolaryngology-head and neck surgery 132. 1: 55-62.

Hu, W., Xu, R., Zhang, G., Jin, J., Szulc, Z.M., Bielawski, J., Hannun, Y.A., Obeid, L.M., and Mao, C. Golgi fragmentation is associated with ceramide-induced cellular effects. Mol. Bio. Cell (published online ahead of print January 12, 2005).

Taha, T.A., Kitatani, K., Bielawski, J., Cho, W., Hannun, Y.A., and Obeid, L.M. TNF Induces the Loss of Sphingosine Kinase-1 by a Cathespin B Dependent Mechanism. JBC (published online ahead of print February, 2005).

Novgorodov, S.A., Szulc, Z.M., Luberto, C., Jones, J.A., Bielawska, A., Hannun, Y.A., and Obeid, L.M. (2005) Positively Charged Ceramide is a Potent Inducer of Mitochondrial Permeabilization. Accepted for publication JBC.

Thompson, C.R., Shankar, S.I., Melrose, N., VanOosten, R., Johnson, K., Pitson, S.M., Obeid, L.M., and Kusner, D.J. (2005) Sphingosine Kinase 1 (SK1) is Recruited to Nascent Phagosomes in Human Macrophages. Inhibition of SK1 Translocation by Mycobacterium tuberculosis. (in press).

Pettus, B. J., Kitatani, K., Chalfant, C. E., Taha, T. A., Kawamori, T., Bielawski, J., Obeid, L. M., and Hannun, Y. A., (2005) The Coordination of Prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol. Pharm (in press).

Spassieva, S., Sims, K., and Obeid, L.M. (2005) Structural and signaling functions of yeast sphingolipids-two sides of the same coin. In: Cell Biology and Dynamics of Yeast Lipids. Editor A. Gayathri, Research Signpost. (in press).


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