Department of Neuroscience
Lawrence Middaugh, Ph.D.
Department of Psychiatry & Behavioral Sciences
AB, 1961, Psychology, University of Kansas, Lawrence, Kansas
MA., 1966, Psychology, Experimental-Clinical, University of Missouri, Kansas City, Missouri
PhD, 1970, Psychology, Physiological, University of Tennessee, Knoxville, Tennessee
Dr. Middaugh is a Professor in Center for Drug and Alcohol Programs (CDAP) and has a thirty three years of research experience utilizing murine models to examine the effects of abused drugs (alcohol, amphetamine, cocaine, methadone, and phenobarbital) delivered to either developing or adult animals on behavior and neurochemical parameters.
Recent research has focused on examining the efficacy of potential pharmacotherapeutic agents on the discriminative and rewarding effects of ethanol as part of the Charleston Alcohol Research Center [NIAAA funded]. As part of the Women's Research Center, this work has been extended to study the influence of gender on the effectiveness of potential therapeutic agents for alcohol abuse [NIDA funded]. A third project investigates the impact of dopamine D1 receptor gene deletion on cocaine self-administration and relapse, as well the drug's effect on extracellular dopamine [NIDA funded]. Additional current research in collaboration with Dr Tyor, (Neurology Department) includes investigations of cocaine's influence on motor and cognitive deficits associated with HIV encephalitis [NIDA funded], as well as the influence of HAART on HIV in the murine model [NIMH funded].
Finally, we are conducting pilot studies on the influence of over-expression of the dopamine transporter protein via viral vector delivery system on cocaine stimulation, discrimination, and reward, and on the influence of neurotrophic factor gene deletion on aging of dopamine systems. Techniques utilized for these investigations include intracranial, intravenous, and oral drug delivery systems; automated dependent variable measures including motor activity, operant drug discrimination, classical and instrumental conditioning procedures for drug reward, and spatial learning/memory tasks; and in vivo microdialysis to assess neurotransmitter function.