- Neuroscience Institute
Ph.D., Biochemistry, Indian Institute of Science, Bangalore.
The current research efforts in our lab focus on the cellular and molecular mechanisms of neurodegeneration with a particular emphasis on glia-mediated neuroinflammation, a pathogenic process and a potential treatment target, common to a number of degenerative diseases/conditions including Alzheimer’s, Parkinson’s, multiple sclerosis (MS), stroke and brain injury.
Another long-standing interest of ours has been in signal transduction mechanisms regulating the development, differentiation and death of oligodendrocytes - a specialized glial cell type that is responsible for the formation and maintenance of CNS myelin and a target of immune attack in MS.
Specific projects utilize primary cell culture and animal models (i.e., transgenic / knockout and induced) in combination with current cell biological, biochemical and molecular tools and techniques.