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The Neurobiology of Addiction Research Center (NARC)

Publications 2009-2011

2011,  2010, 2009


2011 Publications

NARC Peer-Reviewed Original Research

1. Pendyam S, A Mohan, PW Kalivas and S Nair. 2011. Role of synaptic parameters in neurotransmitter homeostasis – a computational study. Neural Computation, 23: 984-1014.  PMID: 21222526

2. Moussawi K, Riegel A, Nair S, Kalivas PW. Extracellular glutamate: functional compartments operate in different concentration ranges. Front Syst Neurosci. 5:94; 2011; PMID: 22275885

3. Reissner KJ, JD Uys, JH Schwacke, C Walters, TE Dunn, JB Blumer, DM Townsend and PW Kalivas.  2011.  Proteomic analysis reveals a role for AKAP signaling in the reinstatement of cocaine seeking.  J Neuroscience, 31: 5648-58. PMID: 21490206.

4. Sondheimer I, Knackstedt LA. Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking. Behav Brain Res. 2011 Nov 20;225(1):252-8. Epub 2011 Jul 30.

5. Moorman, D. and Aston-Jones, G., Orexin/Hypocretin Modulates Response of Ventral Tegmental Dopamine Neurons to Prefrontal Activation: Diurnal Influences. J. Neurosci. 30: 15585-15599 (2010).

6. Whitfield TW, Shi XD, Sun WL McGinty JF. 2011. The suppressive effect of an intra-prefrontal cortical infusion of BDNF on cocaine–seeking is Trk receptor and ERK MAP kinase-dependent. J Neurosci 31:834-842. PMCID: PMC2819624

7. Hearing MC, Schwendt M, McGinty JF. 2011. Suppression of activity-regulated cytoskeleton gene expression in the dorsal striatum attenuates extinction of cocaine-seeking. Intl J Neuropsychopharmacology 14:784-795. PMCID:PMC3120104

8. Moussawi K, W Zhou, HW Shen, C Reichel, RE See, DB Carr and PW Kalivas.  2011.  Reversing cocaine-induced synaptic potentiation provides long-lasting protection from relapse. PNAS, 108: 385-390.  PMID: 21173236.

9. Reichel CM, K Moussawi, PH Do, PW Kalivas and RE See.  2011.  Chronic N-acetylcysteine during abstinence or extinction following cocaine self-administration produces enduring reductions in drug-seeking.  J Pharmacol Exp Ther, 337: 487-493 PMID: 21303920.

10. Wiggins A, RJ Smith, HW Shen and PW Kalivas.  2011.  Integrins modulate relapse to cocaine-seeking. J Neuroscience, 31: 16177-16184. PMID: 22027492.

11. Reissner KJ, GC Sartor, EM Vazey, G Aston-Jones and PW Kalivas. 2011. Use of vivo-morpholinos for control of gene expression in the adult rat brain. J Neurosci Meth, 203: 354-360. PMID: 22027492.

12. Luo, A.H., Tahsili-Fahadan, P., Wise, R.A., Lupica, C.R. and Aston-Jones, G., Linking Context with Reward: A Functional Circuit from CA3 of Hippocampus to Ventral Tegmental Area. Science 333: 353-357 (2011).

13. McGinty JF, Bache AJ, Coleman NT, Sun W-L. The role of BDNF/TrkB signaling in acute amphetamine-induced locomotor activity and opioid peptide gene expression in the rat dorsal striatum. Front Syst Neurosci. 5:60-68, 2011. PMC3143721


NARC Peer-Reviewed, Published Reviews

1. Kalivas PW and ND Volkow.  2011.  New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiat, 16: 974-986. PMID 21519339.

2. Zhou L, Sun WL, See RE (2011) Orexin receptor targets for anti-relapse medication development. Pharmaceuticals 4:804-821.

3. Javitt DC, D Schoepp, PW Kalivas, ND Volkow, C Zarate, K Merchant, M Bear, D Umbricht, M Hajos, W Potter and C-M Lee.  2011.  Translating glutamate:  from pathophysiology to treatment.  Sci Trans Med, 2011 Sept 28; 3 (102)/ PMID: 21957170.

4. McGinty VB, Hayden BY, Heilbronner SR, Dumont EC, Graves SM, Mirrione MM, du Hoffmann J, Sartor GC, España RA, Millan EZ, Difeliceantonio AG, Marchant NJ, Napier TC, Root DH, Borgland SL, Treadway MT, Floresco SB, McGinty JF, Haber S. Emerging, reemerging, and forgotten brain areas of the reward circuit. Behav Brain Res. 225:348-57, 2011.


NARC Invited Editorials, Perspectives and Chapters

1. Gipson, CD and PW Kalivas.  2011.  Pharmacotherapies in drug addiction.  In: Drug Discovery for Psychiatric Disorders. Rankovic, Z., Bingham, M., Hargreaves, R., & Nestler, E. (Eds).  Royal Society of Chemistry.

2. Gipson, CD and PW Kalivas. 2011.  Neural Basis of Drug Addiction.  In: Neurobiology of Drug Abuse in Adolescents, São Paulo, Brazil.

3. McGinty JF, Mendelson JE. Is brain-derived neurotrophic factor a selective biomarker that predicts cocaine relapse outcomes? Biol. Psychiatry 70:700-1, 2011.


2010 Publications

NARC Peer-Reviewed Original Research

1. Ramamoorthy S, Samuvel DJ, Balasubramaniam A, See RE, Jayanthi LD (2010) Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats.  Biochem Biophys Res Comm; 391(3):1517-1521. PMCID: PMC2812585

2. Li, C., Frantz, K.J. Time-dependent increases in cue-induced reinstatement of sucrose seeking after sucrose self-administration in adolescence.  Behav Brain Res 213(1): 109-112, 2010.

3. Hearing, MC, Schochet, TL, See, RE, McGinty, JF. 2010. Context-driven cocaine-seeking in abstinent rats increases activity-regulated gene expression in the basolateral amygdala and dorsal hippocampus differentially following short and long periods of abstinence. Neuroscience 170:570-579.  PMCID: PMC2934782.

4. Tahsili-Fahadan, P., Carr, G., Harris, G. and Aston-Jones, G. 2010. Modafinil blocks reinstatement of extinguished opiate seeking in rats: mediation by a glutamate mechanism.  Neuropsychopharmacology 35: 2203-2210.

5. McGinty JF, Berglind WJ, Whitfield TW. 2010. Brain-derived neurotrophic factor and cocaine addiction. Brain Res 1314:183-193, 2010. PMCID: PMC2819624

6. Knackstedt LA, RI Melendez and PW Kalivas. 2010. Ceftiraxone restores glutamate homeostasis and prevents relapse to cocaine-seeking. Biol Psychiat, 67: 81-84.  PMID: 19717140

7. LaLumiere RT, KE Niehoff and PW Kalivas. 2010. The infralimbic cortex regulates the consolidation of extinction training after cocaine self-administration. Learning & Memory, 17: 168-175.  PMID: 20332188

8. Knackstedt, LA, R LaLumiere, K Moussawi, M Schwendt, M Klugmann and PW Kalivas. 2010. Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking. J Neuroscience, 30: 7984-7992.  PMID: 20534846  PMC2893028

9. Reissner KJ and PW Kalivas.  2010.  Using glutamate homeostasis as a target for treating addictive disorders.  Behav Pharmacol., 21: 514-522.  PMID: 20634691  PMC2932669

10. Toda S, HW Shen and PW Kalivas. 2010. Inhibition of actin cycling prevents cocaine-induced changes in spine morphology in the nucleus accumbens.  Neurotox Res, 18: 410-15.  PMID: 20336176

11. Smith, R.J., Tahsili-Fahadan, P. and Aston-Jones, G. 2010. Orexin/hypocretin is necessary for context-driven cocaine-seeking. Neuropharmacology 58: 179-184.

12. Moorman, D. and Aston-Jones, G. 2010. Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences. J. Neurosci. 30: 15585-15599.

13. Cason, A.M., Smith, R.J., Tahsili-Fahadan, P., Moorman, D., Sartor, G. and Aston-Jones, G., Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity Physiol. Behav. 100(5): 419-428 (2010).

14. Banna KM, Back SE, Do P and See RE.  2010.  Yohimbine stress potentiates conditioned cue-induced reinstatement of heroin-seeking in rats.  Behav Brain Res. 208: 144-148 PMCID: 2821948

15. Tahsili-Fahadan, P., Malcolm, R. and Aston-Jones, G., Modafinil: A anti-relapse medication, Neuropsychopharmacology 35: 343–344 (2010).


NARC Peer-Reviewed, Published Reviews

1.  Aston-Jones, G., Smith, R.J., Sartor, G., Moorman, D., Massi, L. and Richardson, K., 2010. Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction. Brain Res. 1314:74-90.

2. Moussawi K and PW Kalivas. 2010.  Group II metabotropic glutamate receptors and drug addiction. Eur J Pharmacol, 639:115-122.  PMID: 20371233


NARC Invited Editorials, Perspectives and Chapters

1. Riegel, A and PW Kalivas.  2010.  Lack of inhibition leads to abuse.  Nature (News and Views), 463: 743-744.  PMID: 20148025

2. Reissner KJ and PW Kalivas. 2010. Neurobiology of Substance Abuse Disorders. In: Pediatric Psychopharmacology, 2nd Edition. Chapter 17 pp 237-247. Oxford University Press. 

3. LaLumiere, RT and PW Kalivas.  2010). Drug Priming. In Koob, G, Le Moal, M, and Thompson, R. (eds). Encyclopedia of Behavioral Neuroscience. Academic Press, p. 431-436.

4. Fahadan-Tahsili, P and Aston-Jones, G., Neurobiology of opiate addiction. In: Encycloped. Behav. Neurosci., G. Koob, M. Le Moal and R. Thompson, eds., pp 393-403, Elsevier Press, Amsterdam (2010).

5. Valentino R. and Aston-Jones G., Special issue on neuropeptides in stress and addiction: Overview. Brain Res. 1314:1-2 (2010).


2009 Publications

NARC Peer-Reviewed Original Research

1. Pendyam S, A Mohan, PW Kalivas and S Nair. 2009. Computational model of extracellular glutamate predicts neuroadaptations by chronic cocaine. Neuroscience, 158: 1266-1276.  PMID: 19103434

2. Knackstedt L and PW Kalivas.  2009.  Glutamate and reinstatement.  Curr Op Pharmacol, 9: 59-64.  PMID:  1957986

3. See RE (2009) Dopamine D1 receptor antagonism in the prelimbic cortex blocks the reinstatement of heroin-seeking in an animal model of relapse.  Intl J Neuropsychopharmacol 12:431-436. PMCID: PMC2747000

4. Feltenstein MW, Do PH, See RE (2009) Repeated aripiprazole administration attenuates cocaine-seeking in a rat model of relapse. Psychopharmacology 207:401–411. PMCID: PMC3121303  

5. Smith, R., See, R. and Aston-Jones, G., 2009. Orexin/hypocretin signaling at the OX1 receptor regulates cue-elicited cocaine-seeking. Eur. J. Neurosci.  30: 493-503.

6. Moorman, D.E. And Aston-Jones, G., 2009. Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol-preferring Sprague Dawley rats Alcohol 43: 379-386.

7. Gompf, H., Chen, J., Sun, Y., Yanagisawa, M., Aston-Jones, G. and Kelz, M., 2009. Halothane-induced hypnosis is not accompanied by inactivation of orexinergic output. Anesthesiology 111(5):1001-1009.

8. Pacchioni AM, BS Vallone, PF Worley and PW Kalivas.  2009.  Neuronal pentraxins modulate cocaine-induced neuroadaptations.  J Pharmacol Exp Ther, 328: 183-192.  PMID: 18840757

9. Moussawi K, AM Pacchioni, M Moran, MF Olive, JT Gass, A Lavin and PW Kalivas.  2009.  N-acetylcysteine reverses cocaine induced metaplasticity. Nat Neurosci, 12: 182-189.  PMID:  19136971

10. Shen HW, S Toda, K Moussai, A Bouknight, S Zahm and PW Kalivas.  2009.  Altered dentritic spine plasticity in cocaine-withdrawn rats. J Neuroscience, 29: 2876-2884.  PMID: 19261883.

11. Knackstedt AL, S LaRowe, P Mardikian, R Malcolm, H Upadhyaya, S Hedden, A Markou and PW Kalivas.  2009.  The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biol Psychiat, 65: 841-845.  PMID: 1910343

12. Peters J, PW Kalivas and G Quirk.  2009.  Shared prefrontal mechanisms regulating the extinction of both fear and addiction.  Learning Memory, 16: 279-288.  PMID: 19380710

13. Berglind WJ, TW Whitfield, RT LaLumiere, PW Kalivas and JF McGinty.  2009.  A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens. J Neuroscience, 29: 3715-3719.  PMID: 19321768

14. Pacchioni AM and PW Kalivas. 2009. The role of AMPAR trafficking mediated by neuronal pentraxins in cocaine-induced neuroadaptations.  Mol Cell Pharmacol, 1: 183-192.  PMID: 20336176

15. Luo, A. and Aston-Jones, G., Circuit projection from suprachiasmatic nucleus to ventral tegmental area: A novel circadian output pathway. Europ. J. Neurosci. 29: 748-760 (2009).

16. Mejias-Aponte, C. and Aston-Jones, G., Adrenergic and noradrenergic innervation of midbrain dopamine neurons: Prominent inputs from medullary homeostatic centers. J. Neurosci. 29: 3613-3626 (2009).

17. Smith, R., See, R. and Aston-Jones, G., Orexin / hypocretin signaling at the OX1 receptor regulates cue-elicited cocaine-seeking. Europ. J. Neurosci.  30: 493-503 (2009).


NARC Peer-Reviewed, Published Reviews

1. Aston-Jones, G., Smith, R.J., Moorman, D. and Richardson, K., 2009.  Role of lateral hypothalamic orexin neurons in reward processing and addiction, Neuropharmacology 56 (Suppl 1): 112- 121.

2. Yahyavi-Firouz-Abadi N, See RE (2009) Anti-relapse medications: Preclinical models for drug addiction treatment.  Pharmacology & Therapeutics 124(2):235-247. PMCID:PMC2889132

3. Kalivas, PW, RT LaLumiere, L Knackstedt and H Shen.  2009.  Glutamate transmission in addiction.  Neuropharmacology, 56: 169-173.  PMID: 18675832

4. Kalivas, PW.  2009.  The glutamate homeostasis hypothesis of addiction.  Nature Rev Neuroscience, 10: 561-572.  PMID: 19571793

5. Jalabert, M., Aston-Jones, G., Manzoni, O. and Georges, F., Role of the bed nucleus of the stria terminalis in the control of ventral tegmental area dopamine neurons, Prog. Neuro-Psychopharm. Biol. Psychiat. 33: 1336-1346 (2009).

6. McGinty VB, Hayden BY, Heilbronner SR, Dumont EC, Graves SM, Mirrione MM, du Hoffmann J, Sartor GC, España RA, Millan EZ, Difeliceantonio AG, Marchant NJ, Napier TC, Root DH, Borgland SL, Treadway MT, Floresco SB, McGinty JF, Haber S. Emerging, reemerging, and forgotten brain areas of the reward circuit. Behav Brain Res. 225:348-57, 2011.


NARC Invited Editorials, Perspectives and Chapters

1. Torregrossa MM and PW Kalivas. 2009. Addictive processes. In, Handbook of Neuroscience for Behavioral Scientists, Eds Gary G Berntson and John T Cacioppo, John Wiley and Sons, NY, in press

2. See RE and PW Kalivas. 2009. Neuroscience of substance abuse and dependence. In: Kaplan & Sadock's Comprehensive Textbook of Psychiatry, Eds. Sadock BJ, Sadock VA, Ruiz P, 9th edition, Lippincott Williams & Wilkins.

3. Olive MF and PW Kalivas. 2009.  Conditioning in addiction.  In: Addiction Medicine, Ed BA Johnson, Springer, New York.

4. Pierce RC and PW Kalivas. 2009. Locomotor behavior. Curr Protoc Neurosci, Chap 8, Unit 8.1.  PMID: 18428664

5. Uys J and PW Kalivas.  2009.  Cocaine Dependence. Encyclopedia of Pharmacol, Ed. Ian Stoleman, Springer-Verlag, New York.

6. Kalivas, PW.  2009.  The manifest destiny of cocaine research.  Neuropsychopharmacol (Perspective), 34: 1089-1090.  PMID:  19194378

7. Moorman, D. And Aston-Jones, G., Optical control of reward. Nature 458 (7241): 980-981. (2009).

8. Smith, R. and Aston-Jones, G., Inactivating the activated: Identifying behavioral functions of local neural networks. Nature Neurosci. 8: 965-966 (2009).

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