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Battling the opioid epidemic

MUSC experts pull together to help stem the tide

Dr. Brady and colleagues
MUSC has a team of researchers focused on fighting addiction, led by Dr. Kathleen Brady, who's standing in front.
Dawn Brazell | brazell@musc.edu | September 6, 2017

The graphs tell the sobering tale. South Carolina’s rate of opioid abuse or dependence falls in the second highest category in the nation, yet its ability to treat people dependent on opioids falls into the lowest range.

That’s not acceptable, said Kathleen Brady, a psychiatrist and researcher who specializes in addiction at the Medical University of South Carolina and serves as president of the International Society of Addiction Medicine.

Americans consume more opioids than people in any other country in the world. More than 142 Americans die every day from a drug overdose. Drug overdoses now kill more people than gun homicides and car crashes combined, according to an interim report by the President's Commission on Combating Drug Addiction and the Opioid Crisis. 

“These are by and large preventable deaths. It’s an emergency and we need to do something about it,” said Brady, adding that there were 750 opioid-related deaths in South Carolina in 2015. “That means two people a day died. That number was 33,000 for the U.S. Someone died every 20 minutes from an opioid overdose, and none of those deaths should have happened. None of them."

graphic showing opioid deaths

Graphic courtesy of South Carolina Department of Health and Environmental Control


MUSC, which has a long list of researchers and clinicians with addiction expertise, wants to bridge the gap between the need for treatment and access to it. 

It’s why MUSC is spearheading several efforts to stem the tide, including the SC MAT ACCESS project, or Medication-Assisted Treatment – Academic Community Capacity Expansion for Sustainable Success.

Researchers and doctors at MUSC are partnering with the South Carolina Department of Alcohol and Other Abuse Services, or DAODAS, to maximize the impact of the recently awarded 21st century CURES funding. When Brady learned of the funding, she knew MUSC had to help.

“We have so much expertise in addiction that I immediately contacted the people in our state and I said, ‘How can we help? The team at MUSC would like to help the state combat this.’ We decided our best role would be taking the piece of this initiative that really involved engaging physicians and practitioners throughout the state in best practices around pain management, and management of addictions and teaching them about evidence-based care in the treatment of addictions.”  

So far, MUSC has $2 million of the total $6.7 million the state will get to combat the opioid epidemic over the next two years.

“I’m very excited about the outreach to physicians across the state. We need to make this sustainable,” Brady said. “The opioid epidemic is a terrible thing, but the one upside of it is that it has brought a tremendous amount of attention to addictions.” 

How the network will help

The plan is to use an interactive website to educate doctors and the public about the best treatments for opioid dependency and pain based on what research has shown to be the most effective. The project also will involve the creation of a network of telehealth providers throughout the state who are using medication-assisted therapies. They will have access to weekly teleconferences, where half of the time will be spent on an educational component, such as alternative treatments for pain. The remaining time will be spent on case issues that doctors bring up.

Brady said nobody who needs the services of the SC MAT ACCESS project should be left out, so the network will reach out to primary care doctors across the state and give them one-on-one information about it. And the communication goes both ways — any doctor can contact MUSC specialists in addiction and pain management through the network, and within 24 hours someone will get back to them to talk through a case or provide an appropriate referral.

“We’re here to help,” Brady said. “No one is going to be stranded out there in the rural areas, struggling with how to deal with this.”

Dr. Brady says attitudes about addiction have to change.


The approach is based on an innovative plan called Project ECHO, or Extension for Community Healthcare Outcomes, that is being used by the University of New Mexico. The goal of this model is to break down the walls between specialty and primary care by linking experts at an academic ‘hub’ with primary care doctors and nurses in nearby communities.

Basically, medication-assisted treatments involve using any one of a number of medications to help people with opioid dependence become more functional. Methadone can only be dispensed through an opioid treatment program, of which there are 16 in South Carolina. “They are not in every county and sometimes they are miles apart,” Brady said.

Another medication, buprenorphine, is now available in an implant that lasts six months and is expected to soon be available in an injectable form that will last one month. 

“There are physicians who are able to prescribe buprenorphine in South Carolina, but they are all focused in our urban areas. In Georgetown, there are only five physicians and Horry County is one of our worst areas as far as overdoses go.”

Doctors are limited to how many people they can treat. Another issue is cost. Medicaid just started covering buprenorphine in the state, and even with that, it can take several layers of authorization to get it approved, she said. “And a lot of insurances don’t cover it.”

The network will help with that. In the short term, it will provide medications for people who can’t afford them. The SC MAT ACCESS project will also raise awareness and provide linkage to treatment programs that are part of the Department of Alcohol and Other Drug Abuse Services. “DAODAS  has programs in most counties throughout South Carolina. They are doing state-of-the-art addiction treatment, but many do not offer MAT,” Brady said. “There are too few of them, and people aren’t referred to them from their primary care. Even when they are, payment is a problem, and these centers are operating on a shoestring budget.”

Lack of funding and insurance coverage will have to be addressed, Brady said. MUSC doctors and researchers will have strong representation at the 2017 SC Governor’s Opioid Summit and are working with state legislators to come up with solutions. 

The Substance Abuse and Mental Health Services Administration issues block grants to every state for the treatment of addictions. It funds DAODAS, and each state is supposed to match that grant. “Some states do more than match it. Some states, like California, they give extra. SAMHSA has the right to take it away if your state doesn’t match it.”

Brady said she’s glad to see more engagement from state legislators to address the opioid epidemic. 

Changing culture 

To stem the opioid crisis, it’s important to get to the root of the problem. It’s not just about “addicts” out searching for drugs, she said.

“There is a lot pain. Pain is the No. 1 reason people go to the doctor. You can’t ignore it, but we need to find better ways to treat it. Doctors have gotten a bit of a bad rap in all this because much of the opioid epidemic stems from medications that are prescribed. But in the 1990s, they called pain the fifth vital sign. Doctors have been pushed pretty aggressively to manage pain. Adequate treatment of pain is one of the leading indicators of patient satisfaction.”

There has been very little research about alternative treatments for pain, but what research has shown so far is that opiates are one of the most effective, at least in the short term, treatments available, she said.

Long term, it’s a different story, so one goal of the network will be to teach doctors better methods for pain management and to develop new options.

“Doctors have gotten little education about opioids and the dependence-producing capabilities or about alternate ways of managing pain. Insurers often don’t pay for alternative, multi-modal treatments of pain. Insurers, all too often, also don’t pay for the treatment of addictions. This is an opportunity to change some of this for the better.”

Dr. Kelly Barth

Dr. Kelly Barth will lead a new pain rehabilitation program at MUSC Health.


At the 2017 SC Governor’s Opioid Summit, MUSC clinicians and researchers will be lobbying for sustainable change. Among those attending will be Kelly Barth, a psychiatrist and internal medicine doctor at MUSC Health who specializes in the management of chronic pain and opioid dependence.

She’s excited to be starting the MUSC Health Intensive Program for Pain Rehabilitation, a three-week outpatient program where pain patients receive daily physical therapy, psychotherapy and medical management — all while being weaned off their opioid pain medications. “We need a civilized exit plan so we’re not abruptly taking people off their pain medications,” Barth said. "There’s a huge need to treat chronic pain. We need to change the culture of how we treat pain.”   

Attitudes about addiction also need to change, Brady said.

In the long run, we must leverage this for sustainability. We must use this bully pulpit afforded by the opioid epidemic and his short-term funding to create an opportunity to talk about an infrastructure and systems for early detection and prevention and systems to access treatment. We have to make it more acceptable and accessible.”

She hopes more people will realize addiction is a disease. “We have effective treatments. We need to come out of the closet as far as our awareness of these addictions. We need to destigmatize these disorders so people will feel more comfortable accessing the effective treatments we do have.”

There’s a need for public figures to talk about it, but also for people to open up in their private and social settings to start conversations, she said.

“If you think about this, one in four to five people in the U.S. has had an addiction at some point in their life. They are all over the place — your boss, your friends — but they probably don’t talk about it. Addictions affect people of all races, religions and socioeconomic class. They are curable, so it’s critically important that we encourage people to get the treatment they need.”


What you should know about opioid use

Dr. Kathleen Brady's top tips for patients:

  • You can take responsibility for your pain management. If you’ve had a procedure that causes pain, you should take opiates as needed. But if you take an opiate daily for three weeks or more, you are going to have some level of physical dependency. 
     
  • Ask your doctor about tapering. Take opioids only as needed and supplement with other non-opioid type medications.
     
  • Opioids are not the best treatment for chronic pain. If the pain turns from acute to chronic, then seek alternative treatments, such as electrical stimulation treatments or other medications. Antidepressants, non-steroidals like Ibuprofen and anti-seizure medicines can work.
     
  • When you are prescribed opiates, treat them with care. Many of the overdoses in kids are teenagers raiding their family’s medicine cabinets. These should be kept in locked compartments and disposed of properly. It’s a recipe for disaster.
     
  • Beware of new drug imports. Brady said fentanyl is probably 10 times as potent as morphine. Carfentanil, used to tranquilize large animals, is 1,000 times more potent. “Carfentanil, especially, will kill you in a second, and it’s getting mixed in with other drugs. People think they are buying heroin.”

MUSC researchers pictured in lead photo, from left to right

Colleen Halliday-Boykins, an associate professor in the Department of Psychiatry and Behavioral Sciences specializing in racial disparities in youth vulnerability to substance use and abuse

Constance Guille, an associate professor in the Department of Psychiatry and Behavioral Sciences specializing in reproductive psychiatry with a focus on opioid use disorder in pregnancy

Ray Anton, a distinguished university professor in the Department of Psychiatry and Behavioral Sciences, specializing in alcohol use disorders, pharmaceutical therapy and biomarker lab tests for alcohol use

Angela Moreland-Johnson, assistant professor in Department of Psychiatry and Behavioral Sciences, specializing in trauma-related consequences and health disparities 

Sarah Book, a professor in the Department of Psychiatry and Behavioral Sciences specializing in the treatment of addiction and psychiatric co-morbidities

Patrick Mulholland, an associate professor in the Department of Neuroscience specializing in addiction

Sudie Back, a professor in the Department of Psychiatry and Behavioral Sciences specializing in addiction and post-traumatic stress disorder

Justin Gass, an assistant professor in the Department of Neuroscience specializing in addiction and post-traumatic stress disorder

Nathaniel Baker, a research instructor in the Department of Public Health Sciences specializing in data analysis and biostatistics

Aimee McRae-Clark, a professor in the Department of Psychiatry and Behavioral Science and director of the Office of Research Integrity specializing in medication development for substance use disorders

Jacqueline McGinty, a professor in the Department of Neuroscience, specializing in addiction biology

Ebele Compean, a resident in the Drug Abuse Research Treatment Program in the Department of Psychiatry and Behavioral Sciences

Kevin Gray, a professor in the Department of Psychiatry and Behavioral Sciences and director of child and adolescent psychiatry specializing in substance use disorders in adolescents and young adults

Christopher Cowan, the William E. Murray Endowed Chair of Excellence, specializing in brain development, autism spectrum disorders and drug addiction
 
Howard C. Becker, a professor and director of the Charleston Alcohol Research Center, specializing in the neuropsychopharmacology of alcohol addiction
 
Peter Kalivas, a professor and chairman of the Department of Neuroscience specializing in neurobiology and synaptic plasticity 
 
Colleen Hanlon, an associate professor in the Department of Psychiatry and Behavioral Sciences specializing in developing brain stimulation as a new treatment for cocaine, alcohol and opiate dependence

Michael Saladin, a professor in the College of Health Professions specializing in addictions, trauma, stress, learning and memory

Kelly Barth, an associate professor in the Department of Psychiatry and Behavioral Sciences specializing in opioids and other pain medications

Lynneice Bowen, a resident in the Drug Abuse Research Treatment Program in the Department of Psychiatry and Behavioral Sciences

Elizabeth Santa Ana, associate professor in the Department of Psychiatry and Behavioral Sciences specializing in testing new ways to deliver evidence-based treatments, group motivational interviewing targeting substance use disorders and tobacco dependence and home-based telehealth for people with substance use disorders

Kathleen Brady is in front.


Figuring out an 'exit plan' for patients stuck on opioids to manage pain (MUSC News, September 5, 2017)

New data: The use of opioid fentanyl is growing in South Carolina, mirroring national trends (The Post and Courier, July 10, 2017)

MUSC becomes first in state to offer special implant to treat opioid dependence (MUSC News, May 4, 2017)

Doctors try to protect babies from the opioid epidemic (MUSC News, May 17, 2016)



 

 

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