Department of Oral Health Sciences
Dr. Viswanathan (Visu) Palanisamy
Room No: 230-F BSB
173 Ashley Ave.
Charleston, SC 29425
Ph.D.: University of Madras, India
Postdoctoral training: University of New Hampshire, Colorado State University and University of California Los Angeles – School of Dentistry
Awards and Honors:
Pathway to Independence career development award K99/R00 – NIH NIDCR (2007-2012)
Outstanding graduate thesis award, (2001) University of Madras, India
Senior Research Fellowship by the Council of Scientific and Industrial
Research, Govt. of India, New Delhi, India. (1997)
Top undergraduate award, Zoology (1990)
Our research focuses on the post-transcriptional regulation that changes oral cancer progression and oral mucositis development via RNA binding proteins (RBPs), which are critical regulators of gene expression in eukaryotic cells. More precisely, we plan to decipher the molecular pathways associated with RBPs such as HuR and CUGBP1 and identify their regulatory roles in oral cancer and mucositis-associated gene regulation. These findings will unravel the studies aiming into therapeutic interventions of RBP-mediated oral diseases.
Talwar S, House R, Sundaramurthy S, Balasubramanian S, Yu H, and Palanisamy V. Inhibition of caspases protects mice from radiation-induced oral mucositis and abolishes the cleavage of RNA-binding protein HuR. J Biol Chem. 2014 Feb 7;289(6):3487-500.
Talwar S, Balasubramanian S, Sundaramurthy S, House R, Wilusz C, Kuppuswamy D, D’Silva N, Gillespie MB, Hill EG and Palanisamy V. Over-expression of RNA-binding protein CELF1 prevents apoptosis and destabilizes pro-apoptotic mRNAs in oral cancer cells. RNA Biology 2013 Jan 16;10(2).
Palanisamy V. Jakymiw A, Van Tubergen EA, D'Silva NJ, Kirkwood KL. Control of cytokine mRNA expression by RNA-binding proteins and microRNAs. J Dent Res. 2012 Jul;91(7):651-8.
Ramachandran S, Palanisamy V. Horizontal transfer of RNAs: exosomes as mediators of intercellular communications. Wiley Interdiscip Rev RNA. 2012 Mar;3(2):286-93.
Sharma S, Gillespie BM, Palanisamy V, Gimzewski JK. Quantitative Nanostructural and Single-Molecule Force Spectroscopy Biomolecular Analysis of Human-Saliva-Derived Exosomes. Langmuir. 2011 Dec 6;27(23):14394-400.
Talwar S, Jin J, Carroll B, Liu A, Gillespie MB, Palanisamy V. Caspase-mediated Cleavage of RNA-binding Protein HuR Regulates c-Myc Protein Expression after Hypoxic Stress. J Biol Chem. 2011 Sep 16; 286 (37):32333-43.
Yu H, Sun Y, Haycraft C, Palanisamy V, Kirkwood KL. MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1. Cytokine. 2011 Jul 4.
Palanisamy V, Wong DT. Transcriptomic analyses of saliva. Methods Mol Biol. 2010;666:43-51. PMCID: 3171800.
Sharma S, Rasool HI, Palanisamy V, Mathisen C, Schmidt M, Wong DT, et al. Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy. ACS Nano. 2010;4(4):1921-6. PMCID: 2866049.
Palanisamy V, Shivani Sharma, Amit Deshpande, Hui Zhou, James Gimzewski, and David T. Wong. Nanostructural and transcriptomic analyses of human saliva derived exosomes. PLoS One, 5(1): e8577,(2010).
Palanisamy V, Noh Jin Park, Jianghua Wang and David Wong: AUF1 and HuR proteins stabilize IL-8 mRNA in human saliva J Dent Res. Aug;87(8):772-6. (2008).
Palaniswamy V, Karen C M Moraes, Carol J Wilusz & Jeffrey Wilusz: Nucleophosmin is selectively deposited on the mRNA during polyadenylation. Nature Structural and Molecular Biology, 2006 May; 13(5):429-35.
Palaniswamy V, Takbum Ohn, Yueh-chin Chiang, Junji Chen, and Clyde L. Denis.Mouse CAF1 can function as a processive deadenylase/3'- 5' exonuclease in vitro but in yeast the deadenylase function of CAF1 is not required for mRNA poly (A) removal. Journal of Biological Chemistry 279: 23988 - 23995. (2004).
Palaniswamy V, Chen J, Chiang YC, Denis CL. Identification of multiple RNA features that influence CCR4 deadenylation activity. Journal of Biological Chemistry 278:14949-14955 (2003).