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Department of Oral Health Sciences

Dr. Hai Yao

Dr.Yao




 Hai Yao, PhD
 Research Associate Professor
 Department of Oral Health Sciences

Contact Information
Clemson-MUSC Bioengineering Program
68 President Street
P.O. Box 250508
Charleston, SC 29425
Phone: 843-876-2380

Education:
Postdoctoral training: Georgia Institute of Technology, 2005, Biomedical Engineering
Ph.D., University of Miami, 2004, Biomedical Engineering
Postdoctoral training: Georgia Institute of Technology, 2005, Biomedical Engineering

Honors and Awards
Finalist - Ph.D. Student Paper Competition at the ASME IMECE, New Orleans (2002).
Finalist - Ph.D. Student Paper Competition at the ASME IMECE, Anaheim (2004).
Finalist - New Investigator Recognition Awards competition at the 52nd annual meeting of the Orthopaedic Research Society, Chicago, IL (2006).
Young Investigators Research Award, AOSpine North America (2007).

Department Affiliations
Medical University of South Carolina, 2006- , Assistant Professor of Craniofacial Biology
Clemson University, 2006- , Assistant Professor of Bioengineering

Research Interests
Biomechanics of TMJ disorders. TMJ disc derangement is a common clinical finding (e.g., dislocation of disc) in patients with TMJ disorders. It has been suggested that degenerative processes predispose the disc to displacement. Although the etiology of disc degeneration is multifactorial, pathological mechanical loading is believed to be the primary cause. Excessive mechanical loading may initiate dysfunctional remodeling resulting in degenerative changes in TMJ disc. However, the molecular mechanism of how mechanical loading at the tissue level initiates remodeling processes at the cellular level (i.e., the mechanobiology of the TMJ disc) is still poorly understood. Thus, the goal of our research is to elucidate the biomechanical etiology of TMJ disc degeneration by understanding the mechanobiology of the TMJ disc. Our approach is to quantitatively determine the complex physicochemical changes (e.g. nutrient level reduction) induced by mechanical forces and understand the TMJ cell response to these physicochemical stimuli.

Publications
Gu WY, Justiz MA, and Yao H, "Electrical conductivity of lumbar annulus fibrosis: effects of porosity and fixed charge density," Spine, 27, 2390-2395 (2002).

Yao H, Justiz MA, Flagler D, and Gu WY, "Effects of swelling pressure and hydraulic permeability on dynamic compressive behavior of lumbar annulus fibrosus," Annals of Biomedical Engineering, 30, 1234-1241 (2002).

Gu WY, Yao H, Huang CY, and Cheung HS, "New insight into deformation-dependent hydraulic permeability of gels and cartilage, and dynamic behavior of agarose gels in confined compression," Journal of Biomechanics, 36, 593-598 (2003).

Gu WY and Yao H, "Effects of hydration and fixed charged density on fluid transport in charged hydrated soft tissues," Annals of Biomedical Engineering, 31, 1162-1170 (2003).Yao H and Gu WY, "Physical signals and solute transport in cartilage under dynamic unconfined compression: finite element analysis," Annals of Biomedical Engineering, 32, 380-390 (2004).

Gu WY, Yao H, Vega AL, and Flagler D, "Diffusion of ions in agarose gels and intervertebral disc: effect of porosity," Annals of Biomedical Engineering, 32, 1710-1717 (2004).Yao H and Gu WY. Physical signals and solute transport in human intervertebral disc during compressive stress relaxation: 3D finite element analysis. Biorheology, 43, 325-335, (2006).

Boyan BD, Wong KL, Wang LP, Yao H, Guldberg RE, Drab M, Jo HJ, and Schwartz Z, "Regulation of growth plate chondrocytes by 1,25-dihydroxy vitamin D3 requires caveolae and caveolin-1," Journal of Bone and Mineral Research, 21, 1637-1647 (2006).

Jackson A, Yao H, Brown MD, and Gu WY, "Anisotropic ion diffusivity in intervertebral disc: an electrical conductivity approach," Spine, 31, 2783-2789 (2006).Yao H and Gu WY, "Convection and diffusion of solute in charged hydrated soft tissues: a mixture theory approach," Biomechanics and Modeling in Mechanobiology, 6, 63-72 (2007).

Yao H and Gu WY, "Three-dimensional inhomogeneous triphasic finite element analysis of physical signals and solute transport in human intervertebral disc under axial compression," Journal of Biomechanics, 40, 2071-2077 (2007).

Rubin J, Schwartz Z, Boyan B, Fan X, Case N, Sen B, Drab M, Smith D, Aleman M, Wong K, Yao H, Jo H, and Gross T, "Caveolin-1 knock-out mice have increased bone size and stiffness," Journal of Bone and Mineral Research, 22, 1408-1418 (2007).

Schwartz Z, Zhao G, Raz P, Barak Y, Tauber M, Yao H, and Boyan BD, "Micron scale roughness on the surface of ti6al4v pedicle screws enhances osteoblast differentiation in vitro and osteointegration in sheep spine in vivo," Journal of Bone and Joint Surgery (American volume), 90, 2485-2498 (2008).

Yao H, Schwartz Z, Guldberg RE, and Boyan BD, "Sex dependant bone phenotype of vitamin D receptor ablated mice," Journal of Bone and Mineral Research, in review (2008).

Ebbert M, Chapman J, DesJardins J, LaBerge M, and Yao H, "Surface-regional dependant frictional coefficient of porcine TMJ disc," ASME Journal of Biomechanical Engineering, in review.

Kuo J, Bacro TRH, and Yao H, "Biphasic viscoelatic behavior of human TMJ disc under confined compression," Journal of Biomechanics, in review.

Kuo J, Wu YR, Zhang LX, and Yao H, "Viscoelastic compressive and shear properties of porcine TMJ disc," Journal of Dental Research, in review.

Kuo J, Wu YR, Zhang LX, and Yao H, "Biochemical composition and viscoelastic properties of porcine TMJ condyle cartilage," Annals of Biomedical Engineering, in review.