Department of Oral Health Sciences
Dr. Hong Yu
Hong Yu, M.D.
Research Associate Professor
Department of Oral Health Sciences
Hong Yu, M.D.
BSB 230A - Office
BSB 234 - Lab
173 Ashley Ave.
Charleston, SC 29425
M.D., Beijing Medical University
Postdoctoral Training, Medical University of South Carolina
Honors and Awards:
Ivy Wu research fellowship, Queen Mary Hospital, the University of Hong Kong, Hong Kong, China (1998)
National Research Service Award, Post Doctoral Training, Medical University of South Carolina
Manuscript reviewer: Plos One, Anti-Cancer Agents in Medicinal Chemistry, Journal of Lipid Research, Journal of Immune Research, Editorial Review Board of Journal of Dentistry and Oral Biology
Oral Health Sciences, College of Dental Medicine
Molecular and Cellular Biology and Pathobiology Program, College of Graduate Studies
Periodontitis is a common inflammatory bone loss disease caused by bacterial infection. Oral pathogens induce the generation of inflammatory mediators, including the bioactive sphingolipid sphingosine-1-phosphate (S1P), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and receptor activator of nuclear factor kappa-B ligand (RANKL). These inflammatory mediators attract monocytes and macrophages from blood circulation to periodontal tissues, where these immune cells can fuse to form multinucleated osteoclasts (bone-resorbing cells), leading to bone loss. Our lab has demonstrated that S1P receptor 2 (S1PR2), a G-protein-coupled receptor on the plasma membrane of cells, plays a key role in regulating the inflammatory bone loss response induced by oral pathogens. Our research project will determine 1) how S1PR2 regulates the generation of inflammatory mediators (S1P, IL-1β, IL-6, TNF-α, and RANKL); 2) how S1PR2 controls the chemotaxis of monocytes and macrophages (osteoclast precursors) induced by bacterial infection; 3) how S1PR2 affects the adhesion and fusion of monocytes and macrophages to form multinucleated osteoclasts induced by RANKL; and 4) if pharmacological inhibition of S1PR2 signaling can become a novel therapeutic strategy for periodontitis.
Yu H. Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis. PLoS One. 2016 May 25;11(5)
Fugle CW, Zhang Y, Hong F, Sun S, Westwater C, Rachidi S, Yu H, Garret-Mayer E, Kirkwood K, Liu B, Li Z. CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells. Oncoimmunology. 2016 Sep 26;5(10)
Yu H, Sun C, Argraves KM. Periodontal inflammation and alveolar bone loss induced by Aggregatibacter actinomycetemcomitans is attenuated in sphingosine kinase 1-deficient mice. J Periodontal Res. 2015 Apr 20.
Yu H, Herbert BA, Valerio M, Yarborough L, Hsu LC, Argraves KM. FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans. Lipids Health Dis. 2015 Jul 4
Alexander-Bryant AA, Dumitriu A, Attaway CC, Yu H, Jakymiw A. Fusogenic-oligoarginine peptide-mediated silencing of the CIP2A oncogene suppresses oral cancer tumor growth in vivo. J Control Release. 2015 Nov 28;218:72-81.
Valerio MS, Herbert BA, Basilakos DS, Browne C, Yu H, Kirkwood KL. Critical role of MKP-1 in lipopolysaccharide-induced osteoclast formation through CXCL1 and CXCL2. Cytokine. 2014 Sep 24;71(1):71-80.
Jin J, Zhang X, Lu Z, Li Y, Lopes-Virella MF, Yu H, Haycraft CJ, Kirkwood KL, Huang Y. Simvastatin inhibits lipopolysaccharide-induced osteoclastogenesis and reduces alveolar bone loss in experimental periodontal disease. J Periodontal Res. 2014 Aug;49(4):518-26. Epub 2013 Oct 7.
Jin J, Machado ER, Yu H, Zhang X, Lu Z, Li Y, Lopes-Virella MF, Kirkwood KL, Huang Y. Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome. J Dent Res. 2014 Mar;93(3):294-9. Epub 2013 Dec 18.
Talwar S, House R, Sundaramurthy S, Balasubramahian S, Yu H, Palanisamy V. Inhibition of caspases protects mice from radiation induced oral mucositis and abolishes the cleavage of RNA binding protein HuR. J Biol Chem 2014 Feb 7;289(6):3487-500. Epub 2013 Dec 20.
Yu H, Valerio M, Bielawski J. Fenretinide inhibited de novo ceramide synthesis and pro-inflammatory cytokines induced by A. actinomycetemcomitans. J Lipid Res. 2013 Jan;54(1):189-201. Epub 2012 Nov 8.
Dunmyer J, Herbert B, Li Q, Zinna R, Martin K, Yu H, Kirkwood KL. Sustained mitogen-activated protein kinase activation with Aggregatibacter actinomycetemcomitans causes inflammatory bone loss. Mol Oral Microbiol. 2012 Oct;27(5):397-407. Epub 2012 Jul 11.
McAbee J, Li Q, Yu H, Kirkwood KL. Sexual dimorphism in periapical inflammation and bone loss from mitogen-activated protein kinase phosphatase-1 deficient mice. J Endod. 2012 Aug;38(8):1097-100. Epub 2012 Jun 8.
Ge C, Yang Q, Zhao G, Yu H, Kirkwood KL, Franceschi RT. Interactions between extracellular signal-regulated kinase 1/2 and P38 map kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity. J Bone Miner Res. 2012 Mar;27(3):538-51.
Yu H, Sun Y, Haycraft C, Palanisamy V, Kirkwood KL. MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1. Cytokine. 2011 Nov;56(2):245-55. Epub 2011 Jul 5.
Trombetta-Esilva J, Yu H, Arias DN, Rossa C Jr, Kirkwood KL, Bradshaw AD. LPS Induces greater bone and PDL Loss in SPARC-null mice. J Dent Res. 2011 Apr;90(4):477-82. Epub 2010 Dec 29.
Li Q, Yu H, Zinna RA, Martin K, Herbert B, Liu A, Rossa C, Kirkwood KL. Silencing MAP Kinase-activated Protein Kinase-2 Arrests Inflammatory Bone Loss. J Pharmacol Exp Ther. 2011 Mar;336(3):633-42. Epub 2010 Dec 7.
Yu H, Li Q, Herbert B, Zinna R, Martin K, Junior CR, Kirkwood KL. Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss. Gene Ther. 2011 Apr;18(4):344-53. Epub 2010 Nov 11.