Department of Oral Health Sciences
Dr. Hong Yu
Hong Yu, M.D.
173 Ashley Ave.
Charleston, SC 29425
M.D., Beijing Medical University
Postdoctoral Training, Medical University of South Carolina, SC
Honors and Awards:
Ivy Wu research fellowship, Queen Mary Hospital, the University of Hong Kong, Hong Kong, China (1998)
National Research Service Award, Post Doctoral Training, NIH/NIDCR T32DE017551
Craniofacial Biology, CDM
Lipid rafts are special microdomains on cell membrane, which are enriched with glycosphingolipids and protein receptors. Lipid rafts play important roles in bacteria internalization, immune signaling transduction, and apoptotic response to various stimuli. Our research is focused on studying the role of lipid rafts in peridontal bacterial infection and oral cancer progression. Furthermore, we are seeking new therapies to treat periodontitis and oral cancer by sphingolipids.
Being the director of Oral Cancer Research Facility, I am also interested in collaborative science with investigators to study aspects in oral cancer carcinogenesis and progression.
Yu H, Sun Y, Haycraft C, Palanisamy V, Kirkwood KL. MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1. Cytokine. 2011 Jul 4. [Epub ahead of print]
Trombetta-Esilva J, Yu H, Arias DN, Rossa C Jr, Kirkwood KL, Bradshaw AD. LPS Induces Greater Bone and PDL Loss in SPARC-null Mice. J Dent Res. 2011 Apr; 90(4): 477-82. Epub 2010 Dec 29.
LiQ, Yu H, Zinna RA, Martin K, Herbert B, Liu A, Rossa C, Kirkwood KL. Silencing MAP Kinase-activated Protein Kinase-2 Arrests Inflammatory Bone Loss. J Pharmacol Exp Ther. 2011 Mar;336(3):633-42. Epub 2010 Dec 7.
Yu H, Li Q, Herbert B, Zinna R, Martin K, Junior CR, Kirkwood KL. Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss. Gene Ther. 2011 Apr;18(4):344-53. Epub 2010 Nov. 11.
S. Buff, H. Yu, J. McCall, S. Caldwell, T. Ferkol, T. Flotte, and I. Virella-Lowell. IL-10 delivery by adeno-associated vector attenuates inflammation in mice with Pseudomonas pneumonia. Gene Ther. 2010 May;17(5):567-76. Epub 2010 Apr 1.
Yu H, Zeidan YH, Wu BX, Jenkins RW, Flotte TR, Hannun YA, Virella-Lowell I. Defective acid sphingomyelinase pathway with pseudomonas aeruginosa infection in cystic fibrosis. Am J Repair Cell Mol Biol. 2009 Sep;41(3):367-75. Epub 2009 Jan 23.
H Yu, SM Buff, JE Baatz, and I Virella-Lowell. Oral Instillation with Surfactant Phopholipid: A Reliable Alternative to Intra-tracheal injection in Mice Studies. Lab Anim. 2008 Jul; 42(3):294-304