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Department of Oral Health Sciences

Dr. Hong Yu

 
hong yu photo

Hong Yu, M.D.
Research Assistant Professor
Department of Oral Health Sciences
Co-Director, Laboratory Core of Center for Oral Health Sciences


 

 

 

 

Contact Information:
Hong Yu, M.D.
yuho@musc.edu
BSB 230A - Office
BSB 129A - Lab
173 Ashley Ave.
Charleston, SC  29425
Phone:  843-792-0635
Fax:  843-792-6626

Education:
M.D., Beijing Medical University
Postdoctoral Training, Medical University of South Carolina

Honors and Awards:
Ivy Wu research fellowship, Queen Mary Hospital, the University of Hong Kong, Hong Kong, China (1998)
National Research Service Award, Post Doctoral Training, Medical University of South Carolina

Department Affliations:
Oral Health Sciences, College of Dental Medicine

Research InterestsS1P Signaling
Sphingolipids are essential components of mammalian cell membranes. One of the bioactive sphingolipid is sphingosine-1-phosphate (S1P). S1P binds to five G protein-coupled S1P receptors (S1PR1-5) on the plasma membrane initiating various signaling pathways, which regulate many physiological and pathophysiological processes including cell growth, proliferation, adhesion, chemotaxis, and cytokine production etc. We plan to decipher the role of S1P signaling in the pathogenesis of periodontitis, especially the role of S1P and its receptors on bacterial adherence, leukocyte chemotaxis and attachment, proinflammatory cytokine production, and osteoclastogenesis induced by oral pathogen Aggregatibacter actinomycetemcomitans. Our studies will generate novel anti-inflammatory approaches for periodontitis by targeting S1P signaling.

Recent Publications

Valerio MS, Herbert BA, Basilakos DS, Browne C, Yu H, Kirkwood KL.  Critical role of MKP-1 in lipopolysaccharide-induced osteoclast formation through CXCL1 and CXCL2. Cytokine. 2014 Sep 24;71(1):71-80.

Jin J, Zhang X, Lu Z, Li Y, Lopes-Virella MF, Yu H, Haycraft CJ, Kirkwood KL, Huang Y. Simvastatin inhibits lipopolysaccharide-induced osteoclastogenesis and reduces alveolar bone loss in experimental periodontal disease. J Periodontal Res. 2014 Aug;49(4):518-26. Epub 2013 Oct 7.

Jin J, Machado ER, Yu H, Zhang X, Lu Z, Li Y, Lopes-Virella MF, Kirkwood KL, Huang Y. Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome. J Dent Res. 2014 Mar;93(3):294-9. Epub 2013 Dec 18.

Talwar S, House R, Sundaramurthy S, Balasubramahian S, Yu H, Palanisamy V. Inhibition of caspases protects mice from radiation induced oral mucositis and abolishes the cleavage of RNA binding protein HuR. J Biol Chem 2014 Feb 7;289(6):3487-500. Epub 2013 Dec 20.

Yu H, Valerio M, Bielawski J. Fenretinide inhibited de novo ceramide synthesis and pro-inflammatory cytokines induced by A. actinomycetemcomitans. J Lipid Res. 2013 Jan;54(1):189-201. Epub 2012 Nov 8.

Dunmyer J, Herbert B, Li Q, Zinna R, Martin K, Yu H, Kirkwood KL. Sustained mitogen-activated protein kinase activation with Aggregatibacter actinomycetemcomitans causes inflammatory bone loss. Mol Oral Microbiol. 2012 Oct;27(5):397-407. Epub 2012 Jul 11.

McAbee J, Li Q, Yu H, Kirkwood KL. Sexual dimorphism in periapical inflammation and bone loss from mitogen-activated protein kinase phosphatase-1 deficient mice. J Endod. 2012 Aug;38(8):1097-100. Epub 2012 Jun 8.

Ge C, Yang Q, Zhao G, Yu H, Kirkwood KL, Franceschi RT. Interactions between extracellular signal-regulated kinase 1/2 and P38 map kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity. J Bone Miner Res. 2012 Mar;27(3):538-51.

Yu H, Sun Y, Haycraft C, Palanisamy V, Kirkwood KL. MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1. Cytokine. 2011 Nov;56(2):245-55. Epub 2011 Jul 5.

Trombetta-Esilva J, Yu H, Arias DN, Rossa C Jr, Kirkwood KL, Bradshaw AD. LPS Induces greater bone and PDL Loss in SPARC-null mice. J Dent Res. 2011 Apr;90(4):477-82. Epub 2010 Dec 29.

Li Q, Yu H, Zinna RA, Martin K, Herbert B, Liu A, Rossa C, Kirkwood KL. Silencing MAP Kinase-activated Protein Kinase-2 Arrests Inflammatory Bone Loss. J Pharmacol Exp Ther. 2011 Mar;336(3):633-42. Epub 2010 Dec 7.

Yu H, Li Q, Herbert B, Zinna R, Martin K, Junior CR, Kirkwood KL. Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss. Gene Ther. 2011 Apr;18(4):344-53. Epub 2010 Nov 11.

Yu H, Sun Y, Haycraft C, Palanisamy V, Kirkwood KL.  MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1. Cytokine. 2011 Jul 4. [Epub ahead of print]

Trombetta-Esilva J, Yu H, Arias DN, Rossa C Jr, Kirkwood KL, Bradshaw AD.  LPS Induces Greater Bone and PDL Loss in SPARC-null Mice. J Dent Res. 2011 Apr; 90(4): 477-82. Epub 2010 Dec 29.

LiQ, Yu H, Zinna RA, Martin K, Herbert B, Liu A, Rossa C, Kirkwood KL.  Silencing MAP Kinase-activated Protein Kinase-2 Arrests Inflammatory Bone Loss.  J Pharmacol Exp Ther. 2011 Mar;336(3):633-42.  Epub 2010 Dec 7.

Yu H, Li Q, Herbert B, Zinna R, Martin K, Junior CR, Kirkwood KL.  Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss. Gene Ther. 2011 Apr;18(4):344-53.  Epub 2010 Nov. 11.

S. Buff, H. Yu, J. McCall, S. Caldwell, T. Ferkol, T. Flotte, and I. Virella-Lowell.  IL-10 delivery by adeno-associated vector attenuates inflammation in mice with Pseudomonas pneumonia.  Gene Ther. 2010 May;17(5):567-76.  Epub 2010 Apr 1.

Yu H, Zeidan YH, Wu BX, Jenkins RW, Flotte TR, Hannun YA, Virella-Lowell I.  Defective acid sphingomyelinase pathway with pseudomonas aeruginosa infection in cystic fibrosis.  Am J Repair Cell Mol Biol. 2009 Sep;41(3):367-75.  Epub 2009 Jan 23.

H Yu, SM Buff, JE Baatz, and I Virella-Lowell.  Oral Instillation with Surfactant Phopholipid:  A Reliable Alternative to Intra-tracheal injection in Mice Studies. Lab Anim. 2008 Jul; 42(3):294-304