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β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity

Kinga Majchrzak, Michelle H. Nelson, Jacob S. Bowers, Stefanie R. Bailey, Megan M. Wyatt, John M. Wrangle, Mark P. Rubinstein, Juan C. Varela, Zihai Li, Richard A. Himes, Sherine S.L. Chan, Chrystal M. Paulos

JCI Insight. 2017;2(8):e90547. doi:10.1172/jci.insight.90547.


Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion.

Jacob S. Bowers, Michelle H. Nelson, Kinga Majchrzak, Stefanie R. Bailey, Baerbel Rohrer, Andrew D.M. Kaiser, Carl Atkinson, Luca Gattinoni, Chrystal M. Paulos

JCI Insight. 2017;2(5):e90772. doi:10.1172/jci.insight.90772.


Synthetic RORg agonists regulate multiple pathways to enhance antitumor immunity

Xiao Hua , Xikui Liua , Jacques Moisana , Yahong Wanga , Charles A. Lescha , Chauncey Spoonera , Rodney W. Morgana , Elizabeth M. Zawidzkaa , David Mertza , Dick Bousleya , Kinga Majchrzakb , Ilona Kryczekc , Clarke Taylora , Chad Van Huisa , Don Skalitzkya , Alexander Hurda , Thomas D. Aichera , Peter L. Toogooda , Gary D. Glicka , Chrystal M. Paulosb , Weiping Zouc , and Laura L. Cartera

a Lycera Corp, Ann Arbor, MI, USA; b Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA; c University of Michigan, School of Medicine, Ann Arbor, MI, USA

ONCOIMMUNOLOGY 2016, VOL. 5, NO. 12, e1254854 (13 pages)
http://dx.doi.org/10.1080/2162402X.2016.1254854


Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8+ T cells without host preconditioning

Michelle H. Nelson, Jacob S. Bowers, Stefanie R. Bailey, Marshall A. Diven, Caroline W. Fugle, Andrew D. M. Kaiser, Claudia Wrzesinski, Bei Liu, Nicholas P. Restifo and Chrystal M. Paulos

Journal for ImmunoTherapy of Cancer 2016 4:6 DOI: 10.1186/s40425-016-0110-8

Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic

Kinga Majchrzak, Michelle H. Nelson, Stefanie R. Bailey, Jacob S. Bowers, Xue-Zhong Yu, Mark P. Rubinstein, Richard A. Himes, Chrystal M. Paulos

Cancer Immunol Immunother (2016) 65: 247. doi:10.1007/s00262-016-1797-6


Harnessing the Microbiome to Enhance Cancer Immunotherapy

Michelle H. Nelson, Marshall A. Diven, Logan W. Huff, and Chrystal M. Paulos

Journal of Immunology Research, Volume 2015 (2015), Article ID 368736, 12 pages
http://dx.doi.org/10.1155/2015/368736


Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling

Jacob S. Bowers, Michelle H. Nelson, Sreenath Kundimi, Stefanie R. Bailey, Logan W. Huff, Kristina M. Schwartz, David J. Cole, Mark P. Rubinstein and Chrystal M. Paulos

Clin Cancer Res June 1 2015 (21) (11) 2546-2557; DOI: 10.1158/1078-0432.CCR-14-2294


The Inducible Costimulator Augments Tc17 Cell Responses to Self and Tumor Tissue

Michelle H. Nelson, Sreenath Kundimi, Jacob S. Bowers, Carolyn E. Rogers, Logan W. Huff, Kristina M. Schwartz, Krishnamurthy Thyagarajan, Elizabeth C. Little, Shikhar Mehrotra, David J. Cole, Mark P. Rubinstein and Chrystal M. Paulos


Volume 263, Issue 1, January 2015, Pages 90–105, DOI: 10.1111/imr.12245


Th17 cells in cancer: the ultimate identity crisis

Stefanie R. Bailey, Michelle H. Nelson, Richard A. Himes, Zihai Li, Shikhar Mehrotra, and Chrystal M. Paulos

Front. Immunol., 17 June 2014 | https://doi.org/10.3389/fimmu.2014.00276


The Inducible Costimulator (ICOS) Is Critical for the Development of Human Th17 Cells

Chrystal M. Paulos1, Carmine Carpenito1, Gabriela Plesa1, Megan M. Suhoski2, Angel Varela-Rohena1, Tatiana N. Golovina1, Richard G. Carroll1, James L. Riley1 and Carl H. June1
1Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
2Stanford University School of Medicine, Palo Alto, CA 94305–2296, USA.

Science Translational Medicine  27 Oct 2010: Vol. 2, Issue 55, pp. 55ra78; DOI: 10.1126/scitranslmed.3000448