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Dr. Paulos' Lab

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 Dr. Paulos' Lab | Publications


M.P. Rubinstein, C.A. Cloud, T.E. Garret, C.J. Moore, K.M. Schwartz, C.B. Johnson, D.H. Craig, M.L. Salem, C.M. Paulos, D.J. Cole, Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host. J Am Coll Surg. 214 (4):700-7 (2012).

L. Gattinoni, E. Lugli, Y. Ji, Z. Pos, C.M. Paulos, M.F. Quigley, J.R. Almeida, E. Gostick, Z. Yu, C. Carpenito, E. Wang, D.C. Douek, D.A. Price, C.H. June, F.M. Marincola, M. Roederer, N.P. Restifo, A human memory T cell subset with stem cell-like properties. Nat Med. 17(10):1290-7 (2011).

C.M. Paulos, C. Carpenito, G. Plesa, T.N. Golovina, R. Carroll, J.L. Riley, C.H. June, ICOS critically regulates the expansion and function of inflammatory human Th17 cells. Science Transl Med. 2 (55):55ra78 (2010). *Accompanying Perspective and Science Highlight

Y. Zhao, E. Moon, C. Carpenito, C.M. Paulos, Z. Liu, A.L. Brennan, A. Chew, R.G. Carroll, J. Scholler, B.L. Levine, S.M. Albelda, C.H. June, Multiple Injections of electroporated autologous T cells expressing a chemiric antigen receptor mediate regression of human disseminated tumors, Cancer Res, Oct 2010.
C.M. Paulos and C.H. June, Putting the brakes on BTLA expression for T-cell mediated cancer immunotherapy. J Clin Invest. 120 (1):76-80 (2010).
*C. Wrzesinski, C.M. Paulos, A. Kaiser, P. Muranski, D.C. Palmer, L. Gattinoni, Z. Yu, S.A. Rosenberg, N.P Restifo, Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells. J Immunother, 33(1):1-7 (2010).
L. Gattinoni, X.S. Zhong, D.C. Palmer, Y. Ji, C.S. Hinrichs, Z. Yu, C. Wrzesinski, A. Boni, L. Cassard, L.M. Garvin, C.M. Paulos, P. Muranski, N.P. Restifo. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat Med, 15: 808-813 (2009).
*C.S. Hinrichs, A. Kaiser, C.M. Paulos, L Cassard, L Sanchez-Perez, B. Heemskerk, C. Wrzesinski, Z.A Borman, P. Muranski, N.P. Restifo. Type 17 CD8+ T cells display enhanced anti-tumor immunity. Blood, 114(3):596-9 (2009).
C.M. Paulos, M.M. Suhoski, G. Plesa, T. Jiang, S Basu, T.N. Golovina, S. Jiang, N.A. Aqui, D.J. Jr Powell, B.L. Levine, R.G. Carroll, J.L. Riley, C.H. June, Adoptive immunotherapy: good habits instilled at youth have long-term benefits. Immunol Res. 42(1-3):182-96 (2008).
A. Boni, P. Muranski, L Cassard, C Wrzesinski, C.M. Paulos, D.C. Palmer, L. Gattinoni, C.S. Hinrichs, C.C Chan, S.A. Rosenberg, N.P. Restifo. Adoptive transfer of allogenic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers. Blood, 112(12):4746-54 (2008).
P. Muranski, A. Boni, P.A. Antony, L. Cassard, K.R. Irvine, A. Kaiser, C.M. Paulos, D.C. Palmer, C.E. Touloukian, K. Ptak, L. Gattinoni, C. Wrzesinski, C.S. Hinrichs, C. Chan, N.P. Restifo. Tumor-specific Th17 cells eradiate large established melanoma. Blood, 112(2):32-73 (2008).
D.C. Palmer, C. Chan, L. Gattinoni, C. Wrzesinski, C.M. Paulos, C.S. Hinrichs, D.J. Powell Jr. Z. Yu, C.A. Klebanoff, S.E. Finkelstein, R.N. Fariss, M.E. Dudley, R.B. Nussenblatt, S.A. Rosenberg, N.P. Restifo. Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity. PNAS 105(23):8061-6 (2008).
C.S. Hinrichs, R. Spolski, C.M. Paulos, L. Gattinoni, K.W. Kerstann, D.C. Palmer, C.A. Klebanoff, S.A. Rosenberg, W.J. Leonard, N.P. Restifo, IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood, 111(11):5326-33 (2008).
J.D. Abad, C. Wrzensinski, W. Overwijk, M.A. De Witte, A. Jorritsma, C. Hsu, L. Gattinoni, C.J. Cohen, C.M. Paulos, D.C. Palmer, J.B. Haanen, T.N. Schumacher, S.A. Rosenberg, N.P. Restifo, R.A. Morgan, T-cell receptor gene therapy of established tumors in a murine melanoma model. J Immunother 31(1):1-6 (2008).
C.M. Paulos, A. Kaiser, C. Wrzesinski, C.S. Hinrichs, L. Cassard, D.C. Palmer, A. Boni, P. Muranski, Z. Yu, P.A. Antony, L. Gattinoni, S.A. Rosenberg, N.P. Restifo, Toll-like receptors in tumor immunotherapy. Clin Cancer Res. 15; 13(18 pt. 1):5280-9 (2007).
C.M. Paulos, C. Wrzesinski, A. Kaiser, C.S. Hinrichs, M. Chieppa, L. Cassard, D.C. Palmer, A. Boni, P. Muranski, Z. Yu, L. Gattinoni, P.A. Antony, S.A. Rosenberg, N.P. Restifo, Microbial translocation augments the function of self/tumor-specific CD8+ T cells via TLR4 signaling. J Clin Invest. 117(8):2197-204 (2007).
C. Wrzesinski, C.M. Paulos, L. Gattinoni, D.C. Palmer, A. Kaiser, Z. Yu, S.A. Rosenberg, N.P. Restifo, Hematopoitic stem cells promote the expansion and function of adoptively transferred antitumor CD8+ T cells. J Clin Invest. 117(2):492-501 (2007).
P.A. Antony, C.M. Paulos, M. Ahmadzadeh, A. Akpinarli, D.C. Palmer, N. Sato, A. Kaiser, C.S. Hinrichs, C.A. Klebanoff, Y. Tagaya, N.P. Restifo. IL-2 dependent mechanisms of tolerance and immunity in vivo. J Immunol. 1;176(9):5255-66 (2006).
C.M. Paulos, B. Varghese, G.J. Breur, W.R. Widmer, E. Vlashi, P.S. Low. Folate- targeted immunotherapy effectively treats established experimental arthritis. Arthritis Res and Ther, 8(3):R77 1-10 (2006).
R.H. Baughman and C.M. Paulos. Fungicides, I: Ditalimphos Acta Cryst E61:2352- 2353 (2005).
C.M. Paulos, M.J. Turk, G.J. Breur, P.S. Low. Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv Drug Deliv Rev, 56(8):1205-17 (2004).
C.M. Paulos, J. Reddy, C. Leamon, M.J. Turk, P.S. Low. Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery. Mol Pharmacol, 66(6):1406-14 (2004).
M.J. Turk, G.J. Breur, W.R. Widmer, C.M. Paulos, L. Xu, P.S. Low. Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis and Rheumatism, 46(7):1947-55 (2002).
*Denotes Shared First Author