| Publications
M.P. Rubinstein, C.A. Cloud, T.E. Garret, C.J. Moore, K.M. Schwartz, C.B. Johnson, D.H. Craig, M.L. Salem, C.M. Paulos, D.J. Cole, Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host. J Am Coll Surg. 214 (4):700-7 (2012).
L. Gattinoni, E. Lugli, Y. Ji, Z. Pos, C.M. Paulos, M.F. Quigley, J.R. Almeida, E. Gostick, Z. Yu, C. Carpenito, E. Wang, D.C. Douek, D.A. Price, C.H. June, F.M. Marincola, M. Roederer, N.P. Restifo, A human memory T cell subset with stem cell-like properties. Nat Med. 17(10):1290-7 (2011). C.M. Paulos, C. Carpenito, G. Plesa, T.N. Golovina, R. Carroll, J.L. Riley, C.H. June, ICOS critically regulates the expansion and function of inflammatory human Th17 cells. Science Transl Med. 2 (55):55ra78 (2010). *Accompanying Perspective and Science Highlight | | Y. Zhao, E. Moon, C. Carpenito, C.M. Paulos, Z. Liu, A.L. Brennan, A. Chew, R.G. Carroll, J. Scholler, B.L. Levine, S.M. Albelda, C.H. June, Multiple Injections of electroporated autologous T cells expressing a chemiric antigen receptor mediate regression of human disseminated tumors, Cancer Res, Oct 2010. | | C.M. Paulos and C.H. June, Putting the brakes on BTLA expression for T-cell mediated cancer immunotherapy. J Clin Invest. 120 (1):76-80 (2010). | | *C. Wrzesinski, C.M. Paulos, A. Kaiser, P. Muranski, D.C. Palmer, L. Gattinoni, Z. Yu, S.A. Rosenberg, N.P Restifo, Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells. J Immunother, 33(1):1-7 (2010). | | L. Gattinoni, X.S. Zhong, D.C. Palmer, Y. Ji, C.S. Hinrichs, Z. Yu, C. Wrzesinski, A. Boni, L. Cassard, L.M. Garvin, C.M. Paulos, P. Muranski, N.P. Restifo. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat Med, 15: 808-813 (2009). | | *C.S. Hinrichs, A. Kaiser, C.M. Paulos, L Cassard, L Sanchez-Perez, B. Heemskerk, C. Wrzesinski, Z.A Borman, P. Muranski, N.P. Restifo. Type 17 CD8+ T cells display enhanced anti-tumor immunity. Blood, 114(3):596-9 (2009). | | C.M. Paulos, M.M. Suhoski, G. Plesa, T. Jiang, S Basu, T.N. Golovina, S. Jiang, N.A. Aqui, D.J. Jr Powell, B.L. Levine, R.G. Carroll, J.L. Riley, C.H. June, Adoptive immunotherapy: good habits instilled at youth have long-term benefits. Immunol Res. 42(1-3):182-96 (2008). | | A. Boni, P. Muranski, L Cassard, C Wrzesinski, C.M. Paulos, D.C. Palmer, L. Gattinoni, C.S. Hinrichs, C.C Chan, S.A. Rosenberg, N.P. Restifo. Adoptive transfer of allogenic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers. Blood, 112(12):4746-54 (2008). | | P. Muranski, A. Boni, P.A. Antony, L. Cassard, K.R. Irvine, A. Kaiser, C.M. Paulos, D.C. Palmer, C.E. Touloukian, K. Ptak, L. Gattinoni, C. Wrzesinski, C.S. Hinrichs, C. Chan, N.P. Restifo. Tumor-specific Th17 cells eradiate large established melanoma. Blood, 112(2):32-73 (2008). | | D.C. Palmer, C. Chan, L. Gattinoni, C. Wrzesinski, C.M. Paulos, C.S. Hinrichs, D.J. Powell Jr. Z. Yu, C.A. Klebanoff, S.E. Finkelstein, R.N. Fariss, M.E. Dudley, R.B. Nussenblatt, S.A. Rosenberg, N.P. Restifo. Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity. PNAS 105(23):8061-6 (2008). | | C.S. Hinrichs, R. Spolski, C.M. Paulos, L. Gattinoni, K.W. Kerstann, D.C. Palmer, C.A. Klebanoff, S.A. Rosenberg, W.J. Leonard, N.P. Restifo, IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood, 111(11):5326-33 (2008). | | J.D. Abad, C. Wrzensinski, W. Overwijk, M.A. De Witte, A. Jorritsma, C. Hsu, L. Gattinoni, C.J. Cohen, C.M. Paulos, D.C. Palmer, J.B. Haanen, T.N. Schumacher, S.A. Rosenberg, N.P. Restifo, R.A. Morgan, T-cell receptor gene therapy of established tumors in a murine melanoma model. J Immunother 31(1):1-6 (2008). | | C.M. Paulos, A. Kaiser, C. Wrzesinski, C.S. Hinrichs, L. Cassard, D.C. Palmer, A. Boni, P. Muranski, Z. Yu, P.A. Antony, L. Gattinoni, S.A. Rosenberg, N.P. Restifo, Toll-like receptors in tumor immunotherapy. Clin Cancer Res. 15; 13(18 pt. 1):5280-9 (2007). | | C.M. Paulos, C. Wrzesinski, A. Kaiser, C.S. Hinrichs, M. Chieppa, L. Cassard, D.C. Palmer, A. Boni, P. Muranski, Z. Yu, L. Gattinoni, P.A. Antony, S.A. Rosenberg, N.P. Restifo, Microbial translocation augments the function of self/tumor-specific CD8+ T cells via TLR4 signaling. J Clin Invest. 117(8):2197-204 (2007). | | C. Wrzesinski, C.M. Paulos, L. Gattinoni, D.C. Palmer, A. Kaiser, Z. Yu, S.A. Rosenberg, N.P. Restifo, Hematopoitic stem cells promote the expansion and function of adoptively transferred antitumor CD8+ T cells. J Clin Invest. 117(2):492-501 (2007). | | P.A. Antony, C.M. Paulos, M. Ahmadzadeh, A. Akpinarli, D.C. Palmer, N. Sato, A. Kaiser, C.S. Hinrichs, C.A. Klebanoff, Y. Tagaya, N.P. Restifo. IL-2 dependent mechanisms of tolerance and immunity in vivo. J Immunol. 1;176(9):5255-66 (2006). | | C.M. Paulos, B. Varghese, G.J. Breur, W.R. Widmer, E. Vlashi, P.S. Low. Folate- targeted immunotherapy effectively treats established experimental arthritis. Arthritis Res and Ther, 8(3):R77 1-10 (2006). | | R.H. Baughman and C.M. Paulos. Fungicides, I: Ditalimphos Acta Cryst E61:2352- 2353 (2005). | | C.M. Paulos, M.J. Turk, G.J. Breur, P.S. Low. Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv Drug Deliv Rev, 56(8):1205-17 (2004). | | C.M. Paulos, J. Reddy, C. Leamon, M.J. Turk, P.S. Low. Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery. Mol Pharmacol, 66(6):1406-14 (2004). | | M.J. Turk, G.J. Breur, W.R. Widmer, C.M. Paulos, L. Xu, P.S. Low. Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis and Rheumatism, 46(7):1947-55 (2002). | | *Denotes Shared First Author |
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