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Osteoclast Biology and Bone Disease

Sakamuri V. Reddy, PhD
Professor & Director, Osteoclast Center

In 1988, Dr. Reddy obtained his PhD in Biochemistry from S.V. University, India. He then joined the University of Texas Health Science Center at San Antonio (UTHSCSA) as a postdoctoral fellow and advanced to the rank of associate professor in the department of medicine/hematology, UTHSCSA. He continued his career as an associate professor in the department of medicine/hematology-oncology at the University of Pittsburgh. Dr. Reddy joined the Children's Research Institute at MUSC in July 2004. Dr. Reddy is a recipient Young Investigator Award and Paget's Foundation Award from the American Society of Bone and Mineral Research (ASBMR); NIH R01 Research Awards and Department of Defense (DOD) Medical Research Award, NASA EPSCoR grants from South Carolina. He is also the 2006 recipient of the Mitchell I Rubin Research Excellence Award in the department of pediatrics at MUSC.

Dr. Reddy has been a member of San Antonio Cancer Research Institute, University of Pittsburgh Cancer Institute, ASBMR and a FASEB visiting professor.  He served as an ad hoc member of publications committee of ASBMR (2006-2009), Faculty Tenure Committee, MUSC (2006-2009); Faculty Senate, MUSC (2005-2007). He also served on the International Relations Committee and Medical School Admission Committee for several years at the UTHSCSA, San Antonio. He has also served as a peer reviewer for several national and international scientific journals and funding agencies including the NIH and DOD study sections in the field of arthritis and musculoskeletal disorders. Dr. Reddy has been a mentor for several postdoctoral trainees and graduate students; summer research training of undergraduate and high school students.  He also taught the courses on Biomedical Foundation at the University of Pittsburgh and Bone Remodeling and bone loss for Biomedical Graduate students and residents at the MUSC.  He served as an ad hoc member in several NIH study sections which includes small business grants Review (SBIR/STTR); Tumor microenvironment (TME); Core centers for musculoskeletal diseases, Ruth L. Kirschstein National Research Service Awards for Individual Fellowships and Veteran Administration (VA) merit grants.  Dr. Reddy also served National Cancer Institute grant support panel to site visit National Comprehensive Care Cancer Center. He has also been reviewer for research proposals from international organizations such as Welcome Trust Foundation, British Medical Council, UK. He served on editorial board member of the Journal of Bone and Mineral Research and presently an Academic editor of Plos One online journal.   

Dr. Reddy has published over 100 articles in peer reviewed journals in the field of bone biology and related diseases. He served as an Editor on a recent book released on advances in pathobiology and management of Paget’s disease of bone. He has also been a reviewer for journals such as Nature reviews in endocrinology, Laboratory medicine, Cancer Cell, Developmental Cell, Biochemical Journal, Journal of Pathology (UK), J Cell Science, J Clinical endocrinology and metabolism and Endocrine Reviews. Dr. Reddy has received patents including the Osteoclast Inhibitory Peptide-1 (OIP-1/hSca) which has therapeutic potential for osteoporosis disease. His research interests include (i) Molecular and cellular aspects of osteoclast and osteoblast/stromal cells (ii) Paget's disease of bone, Osteopetrosis, congenital bone fractures in spinal muscular atrophy and (iii) Cancer metastasis to bone. For more information, contact Dr. Reddy at 843-792-6807 or

William L. Ries DDS, PhD

Following his graduation from Alfred University in New York State with a BA degree in Biology, Dr. Ries obtained his DDS and PhD from the State University of NY at Buffalo. His PhD work investigated the cytochemistry and kinetics of cells isolated from periosteal bone surfaces in the adult rat. He further characterized enzymatic activity and nuclear incorporation kinetics in rat osteoclasts on periosteal bone surfaces at Virginia Commonwealth University in Richmond. While at Wake Forest University Medical Center, Winston-Salem, NC his studies moved on to the role of superoxide production in the resorption of bone by osteoclasts and how interference in oxygen radical formation could impair osteoclastic function. At MUSC, in addition to osteoclast biological studies, his expertise in bone histochemistry has been resourceful to clinical trials for the treatment of osteopetrosis and juvenile osteoporosis. For more information, contact Dr. Ries at 843-792-0805 or

Named Best Children's Hospital

The U.S. News & World Report rankings place the MUSC Children’s Hospital heart program among the top 20 in the country. Six MUSC Children’s Hospital divisions are honored in the rankings:

  • Cardiology & Heart Surgery
  • Nephrology
  • Urology
  • Cancer
  • Gastroenterology & GI Surgery
  • Diabetes & Endocrinology