Cell and Molecular Pharmacology & Experimental Therapeutics
Available Graduate Student Positions
Graduate position available to study growth factor receptor tyrosine kinase regulated cancer cell invasion and metastasis. Current work is examining the role of the scaffold protein NEDD9 and its downstream interactions leading to matrix metalloproteinase expression and secretion and invadopodia formation.
Graduate position available to study the role of astrocytes-motor neuron interaction in amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s diseases. In particular, we are interested in the role of mitochondrial dysfunction in the disease and therapeutic strategies targeted to improve mitochondrial antioxidant defenses.
Graduate position available to study protein kinase signaling in breast cancer
This is a unique co-recruitment opportunity for a student interested in both proteomics and molecular signaling in cancer. The prospective student will evaluate changes in protein glycosylation during the process of epithelial to mesenchymal transition (EMT) in prostate cancer.
Graduate position available to study the role of the tumor microenvironment in supporting prostate cancer progression. The focus will be on the intersection of cell signaling, inflammation, and deregulation of microRNAs.
Graduate position available to evaluate the effects of tobacco products on cancer treatment outcomes through clinical, epidemiologic, and biologic investigations. Students preferred with an interest in developing a translational project evaluating chronic exposure and removal of tobacco products on response to radiotherapy and chemotherapy
Graduate student position(s) are open to study the role of the nutrient sensitive enzymes, O-GlcNAc transferase and O-GlcNAcase, on glucose homeostasis and bone metabolism. Current studies are investigating the reciprocal regulation at Ser/Thr residues by O-GlcNAc modification and phosphorylation of key mediators of insulin/IGF1 and PTH signaling by mass spectrometry-based proteomics. Findings revealed by proteomic approaches are evaluated in cellular and transgenic animal models.