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Current Faculty

Ann-Marie Broome, PhD, MBA

Associate Professor
Director, HCC Small Animal Imaging Center

Education

2008  M.B.A., Case Western Reserve University

1998  Ph.D., University of South Carolina

Contact Info

Email: broomea@musc.edu
Tel: 843-792-8975
Fax: 843-792-4810
Office: BSB 313
Webpage: www.broomelab.com

Research Interests

The Broome Translational Medicine & Nanotherapeutic Lab integrates molecular biology, molecular chemistry, and molecular physics to bioengineer molecular imaging agents and bio-mimetic drug delivery vehicles.

Our research team combines expertise in areas of nano-material design, cell engineering, biomarker imaging, immunology, surgery, and oncology in order to develop multi-functional nanoparticles.

The overarching premise of our research is that it is possible to create multifunctional nano-therapeutics and post therapy monitoring tools with an emphasis on the development of a reliable nanotechnology-based solution for those organs where disease is characterized by low survival rates.

Recent Publications

  1. McKinnon, E.; Moore, A.; Dixit, S.; Zhu, Y.; & Broome, A-M. (2016) Fluorescence and bioluminescence imaging of cancers. In: Zeineldin, R. (ed): Methods in Molecular Biology. Cancer Nanotechnology: Methods and Protocols. NY: Springer, in press.
  2. Patel, K.; Broome, A-M.; Atkinson, C.; & Nadig, S. (2016) Organ preservation, ischemia reperfusion injury, and nanotherapeutics in transplantation. In: Nadig, S. & Wertheim, J. (eds): Technological Advances in Whole Organ Transplantation. NY: Springer, in press.
  3. Bredlau, A-L.; Dixit, S.; Chen, C.; & Broome, A-M. (2016) Nanotechnology applications for diffuse intrinsic pontine glioma. Current Neuropharmacology. (Feb 23; E-pub ahead of print). [PMID: 26903150] Impact factor: 3.05
  4. Miller, K.; Dixit, S.; Bredlau, A-L.; Moore, A.; McKinnon, E.; & Broome, A-M. (2016) Delivery of drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers. Nanomedicine – Future Medicine. 11(6): 581-95. [PMID: 27003178] Impact factor 5.41
  5. Meyers, J.; Chung, Y.; Broome, A-M.*; Agnes, R.S.; Wang, X.; Cheng, S.; Burda, C.*; & Basilion, J.P.* (2015) Peptide-Targeted Gold Nanoparticles for Photodynamic Therapy of Brain Cancer. Particle & Particle Systems Characterization. 32(4): 448-457. (*corresponding author) [PMID: 25999665] Impact factor: 0.81
  6. Dixit, S.; Novak, T.; Miller, K.; Zhu, Y.; Kenney, M.E.; Broome, A-M. (2015) Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors. Nanoscale. 7(5): 1782-90. [PMID: 25519743] Impact factor: 7.39
  7. Durst, R.; Peal, D. et al. (2015) Mutations in the DCHS1 gene cause mitral valve prolapse in humans. Nature. 525(7567): 109-13. [PMID: 26258302] Impact factor: 29.65
  8. Dixit, S.; McKinnon, E.; Miller, Zhu, Y.; K.; Novak, T.; Kenney, M.; & Broome, A-M. (2015) Dual receptor-targeted theranostic nanoparticles for localized delivery and activation of PDT drug in glioblastomas. Molecular Pharmaceutics. 12(9): 3250-60. [PMID: 26198693] Impact factor: 8.54
  9. Broome, A-M.*; Ramamurthy, G.; Lavik, K.; Liggett, A.; Kistlinger, I.; & Basilion. J.P.* (2015) Optical imaging of targeted beta-galactosidase in brain tumors to detect EGFR levels. Bioconjugate Chemistry. 26(4): 660-8. [PMCID: PMC4437618] (*corresponding author) Impact factor: 4.82
  10. Nadig, S.N.; Dixit, S.; Levey, N.; Miller, K.; Dennis, W.; Atkinson, C.; & Broome, A-M. (2015) Immunosuppressive nanotherapeutic micelles blunt endothelial cell inflammation and immunogenicity in models of transplantation. RSC Advances: 5(54): 43552-62. [PMID: 26167278] Impact factor: 3.71
  11. Patel, K.J.; Atkinson, C.; Broome, A-M.; McGillicuddy, J.W.; Chavin, K.D.; & Nadig, S.N. (2015) Utilization of machine perfusion and nanotechnology for liver transplantation. Current Transplantation Reports. 2(4): 303-11.
  12. Perera R.H.; Solorio L.; Wu H.; Gangolli M.; Silverman E.; Hernandez C.; Peiris P.M.; Broome A-M.; & Exner A.A. (2014) Nanobubble ultrasound contrast agents for enhanced delivery of thermal sensitizer to tumors undergoing radiofrequency ablation. Pharmaceutical Research. 31(6): 1407-17. [PMCID: PMC3925199] Impact factor: 4.46
  13. Shukla, S.; Wen, A.M.; Ayat, N.R.; Commandeur, U.; Gopalkrishnan, R.; Broome, A-M.; Lozada, K.; Keri, R.A.; & Steinmetz, N.F. (2014) Biodistribution and tumor-homing properties of the filamentous plant virus nanoparticle potato virus X. Nanomedicine. 9(2): 221-35. [PMID: 23834501] Impact factor: 5.06
  14. Agnes, R.S.; Broome, A-M.; Kavik, K.; Verma, A.; Wang, J.; & Basilion, J.P. (2012) An optical probe for noninvasive molecular imaging of orthotopic brain tumors overexpressing epidermal growth factor receptor. Molecular Cancer Therapeutics. 11(10): 2202-11. [PMCID: PMC3829608] Impact factor: 5.23
  15. Perera, R.H.; Krupka, T.M.; Wu, H.; Traughber, B.; Dremann, D.; Broome, A-M.; & Exner, A.A. (2011) Role of pluronic block copolymers in modulation of heat shock protein 70 expression. International Journal of Hyperthermia. 27(7): 672-81. [PMCID: PMC3294295] Impact factor: 2.71
  16. Cheng, Y.; Meyers, J.D.; Agnes, R.S.; Doane, T.; Kenney, M.; Broome, A-M.*; Burda, C.*; & Basilion, J.P.* (2011) Addressing Brain Tumors with Targeted Gold Nanoparticles: A new gold standard for hydrophobic drug delivery. Small. 7(16): 2301-2306. [PMCID: PMC3837553] (*corresponding author) Impact factor: 6.17
  17. Harth, K.C.; Broome, A-M., Jacobs, M.R., Blatnik, J.A.; Zeinali, F.; Bajaksouzian, S.; & Rosen M.J. (2011) Bacterial clearance of biologic grafts used in hernia repair: an experimental study. Surgical Endoscopy. 25(7): 2224-9. [PMCID: PMC3148780] Impact factor: 3.44
  18. Cheng, Y.; Meyers, J.D.; Broome, A-M.*; Kenney, M.E.; Basilion, J.P.*; & Burda, C.* (2011) Deep penetration of a non-covalent PDT drug gold nanoparticle conjugate into tumors. Journal of American Chemical Society. 133(8): 2583-91 [PMCID: PMC3056176] (*corresponding author) Impact factor: 8.58
  19. Sandhu, G.S.; Solorio, L.; Broome, A-M.; Salem, N.; Kolthammer, J.; Shah, T.; Flask, C.; & Duerk, J.L. (2010) Whole animal imaging. Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 2(4), 398–421. [PMID: 20836038]
  20. Broome, A-M.; Bhavsar, N.; Ramamurthy, G.; Newton, G., & Basilion, J.B. (2010) Expanding the functionality of the classic -galactosidase complementation assay: piece by piece. Molecular Pharmaceutics 7: 60-74. Journal Cover Art. [PMCID: PMC2835542] (*corresponding author) Impact factor: 5.4
  21. Halaweish, I.; Harth, K.; Broome, A-M.; Voskerician, G.; Jacobs, M.R.; & Rosen, M.J. (2010) Novel in vitro model for assessing susceptibility of synthetic hernia repair meshes to Staphylococcus aureus infection using green fluorescent protein-labeled bacteria and modern imaging techniques. Surgical Infection 11(5): 449-54. [PMCID: PMC3155689] Impact factor: 1.65
  22. Eckert, R.L.; Sturniolo, M.T.; Broome, A-M.; & Rorke, E.A. (2005) Transglutaminases in Epidermis. In: Mehta, K. and Eckert, R. (eds): Transglutaminases: Family of Enzymes with Diverse Functions. Prog Exp Tum Res. Basel: Karger, 38, 115–124.
  23. Eckert, R.L.; Sturniolo, M.T., Broome, A-M., & Rorke, E.A. (2005) Transglutaminase function in epidermis. Journal of Investigative Dermatology 124: 481-92. [PMID: 15737187] Impact factor: 6.27
  24. Broome, A-M. and Eckert, R.L. (2004) Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor. Journal of Investigative Dermatology 122: 29-38. [PMID: 14962086] Impact factor: 6.27
  25. Editorial Commentary: Määttä, A. (2004) Roads to the edge of the cell: Intracellular transport of cornified envelope precursors. Journal of Investigative Dermatology 122: xii-xiii.
  26. Eckert, R.L.; Broome, A-M.; Ruse, M.; Robinson, N.; Ryan, D.; & Lee, K. (2004) S100 proteins in the epidermis. Journal of Investigative Dermatology 123: 23-33. [PMID: 15191538] Impact factor: 6.27
  27. Efimova, T.; Broome, A-M.; & Eckert, R.L. (2004) PKC regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38-ERK1/2 complex. Molecular Cell Biology 24: 8167-83. [PMCID: PMC515052] Impact factor: 6.19
  28. Broome, A-M.; Ryan, D.; & Eckert, R.L. (2003) S100 protein subcellular localization during epidermal differentiation and psoriasis. Journal of Histochemistry and Cytochemistry 51: 675-85. [PMCID: PMC3785113] Impact factor: 2.73
  29. Efimova, T.; Broome, A-M.; & Eckert, R.L. (2003) A regulatory role for p38 MAPK in keratinocyte differentiation:  evidence for p38-ERK1/2 complex formation. Journal of Biological Chemistry 278: 34277-285. [PMID: 12810719] Impact factor: 5.33
  30. Ruse, M.; Broome, A-M.; & Eckert, R.L. (2003) S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes. Journal of Investigative Dermatology 121: 132-41. Journal Cover Art. [PMID: 12839573] Impact factor: 6.27
  31. Sturniolo, M.; Dashti, S.R.; Deucher, A.; Rorke, E.A.; Broome, A-M.; Chandraratna, R.A.S.; Keepers, T.; & Eckert, R.L. (2003) A novel tumor suppressor protein promotes keratinocyte differentiation via activation of type I transglutaminase. Journal of Biological Chemistry 278: 48066-73. [PMID: 12928434] Impact factor: 5.33

Press Releases & Awards

  1. Medical University of South Carolina (2016, June). Nanotechnology as a Therapeutic Delivery Package. MUSC SCETV Health Focus Radio Shorts. http://etvradio.org/post/nanotechnology-research
  2. Medical University of South Carolina (2016, Summer). Radical Ideas: The enduring promise of antioxidant therapy in cancer. ProgressNotes. http://www.muschealth.org/pn/summer-2016/index.html
  3. National Innovation Award (2016, May). Targeted rapamycin micelle (TRaM) as a therapeutic in solid organ transplant. World TechConnect Conference.
  4. Scicasts (2016, May). Nanocarrier Provides Efficient Delivery of Chemotherapeutic Drug. Sci Nanomedicine. https://scicasts.com/nanotechnology/1863-nanomedicine/11129-nanocarrier-provides-efficient-delivery-of-chemotherapeutic-drug
  5. Medical University of South Carolina (2016, May). Molecular Imaging and Cancer Therapeutics. MUSC SCETV Health Focus Radio Shorts      http://etvradio.org/post/molecular-imaging-research
  6. Medical University of South Carolina (2016, May). Tiny packages my pack powerful treatment for brain tumors. New sCenter & EurekAlert! http://www.eurekalert.org/pub_releases/2016-05/muos-tpm052016.php
  7. Medical University of South Carolina (2015, Year in Review). Precision immunotherapy gets small. MUSC Health: Revealing Tomorrow. http://www.muschealth.org/pn/yir-2015/index.html
  8. Medical University of South Carolina (2015, Spring). A Knockout Punch for Pediatric Brain Tumors?. ProgressNotes. http://www.muschealth.org/pn/spring-2015/index.html
  9. Medical University of South Carolina (2014, Fall). Special Delivery: Personalized drug packaging to reduce organ rejection. ProgressNotes. http://www.muschealth.org/pn/fall-2014/index.html
  10. Case Western Reserve University (2011, February 5). A loose grip provides better chemotherapy. Science Daily.
  11. Case Western Reserve University (2011, March 15). GOLD STANDARD: Hitching anti-cancer drugs to gold nanoparticles delivers faster, more effective treatment. Think.
  12. Case Western Reserve University (2011, March 3). CWRU researchers find improvements to chemotherapy drugs. NewsCenter.
  13. NIH/NIBIB Strategic Plan 2011 (2011, June 1). Developing the interdisciplinary skills of mid-career scientists.
 
 
 

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