Skip Navigation

Current Faculty

Ann-Marie Broome, PhD, MBA

Associate Professor
Director, HCC Small Animal Imaging Center


2008  M.B.A., Case Western Reserve University

1998  Ph.D., University of South Carolina

Contact Info

Tel: 843-876-2481
Fax: 843-792-4810
Office: BSB 313

Research Interests

The Broome Translational Medicine & Nanotherapeutic Lab integrates molecular biology, molecular chemistry, and molecular physics to bioengineer molecular imaging agents and bio-mimetic drug delivery vehicles.

Our research team combines expertise in areas of nano-material design, cell engineering, biomarker imaging, immunology, surgery, and oncology in order to develop multi-functional nanoparticles.

The overarching premise of our research is that it is possible to create multifunctional nano-therapeutics and post therapy monitoring tools with an emphasis on the development of a reliable nanotechnology-based solution for those organs where disease is characterized by low survival rates.

Recent Publications

  1. McKinnon, E.; Moore, A.; Dixit, S.; Zhu, Y.; & Broome, A-M. (2016) Fluorescence and bioluminescence imaging of cancers. In: Zeineldin, R. (ed): Methods in Molecular Biology. Cancer Nanotechnology: Methods and Protocols. NY: Springer, in press.
  2. Patel, K.; Broome, A-M.; Atkinson, C.; & Nadig, S. (2016) Organ preservation, ischemia reperfusion injury, and nanotherapeutics in transplantation. In: Nadig, S. & Wertheim, J. (eds): Technological Advances in Whole Organ Transplantation. NY: Springer, in press.
  3. Bredlau, A-L.; Dixit, S.; Chen, C.; & Broome, A-M. (2016) Nanotechnology applications for diffuse intrinsic pontine glioma. Current Neuropharmacology. (Feb 23; E-pub ahead of print). [PMID: 26903150] Impact factor: 3.05
  4. Miller, K.; Dixit, S.; Bredlau, A-L.; Moore, A.; McKinnon, E.; & Broome, A-M. (2016) Delivery of drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers. Nanomedicine – Future Medicine. 11(6): 581-95. [PMID: 27003178] Impact factor 5.41
  5. Meyers, J.; Chung, Y.; Broome, A-M.*; Agnes, R.S.; Wang, X.; Cheng, S.; Burda, C.*; & Basilion, J.P.* (2015) Peptide-Targeted Gold Nanoparticles for Photodynamic Therapy of Brain Cancer. Particle & Particle Systems Characterization. 32(4): 448-457. (*corresponding author) [PMID: 25999665] Impact factor: 0.81
  6. Dixit, S.; Novak, T.; Miller, K.; Zhu, Y.; Kenney, M.E.; Broome, A-M. (2015) Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors. Nanoscale. 7(5): 1782-90. [PMID: 25519743] Impact factor: 7.39
  7. Durst, R.; Peal, D. et al. (2015) Mutations in the DCHS1 gene cause mitral valve prolapse in humans. Nature. 525(7567): 109-13. [PMID: 26258302] Impact factor: 29.65
  8. Dixit, S.; McKinnon, E.; Miller, Zhu, Y.; K.; Novak, T.; Kenney, M.; & Broome, A-M. (2015) Dual receptor-targeted theranostic nanoparticles for localized delivery and activation of PDT drug in glioblastomas. Molecular Pharmaceutics. 12(9): 3250-60. [PMID: 26198693] Impact factor: 8.54
  9. Broome, A-M.*; Ramamurthy, G.; Lavik, K.; Liggett, A.; Kistlinger, I.; & Basilion. J.P.* (2015) Optical imaging of targeted beta-galactosidase in brain tumors to detect EGFR levels. Bioconjugate Chemistry. 26(4): 660-8. [PMCID: PMC4437618] (*corresponding author) Impact factor: 4.82
  10. Nadig, S.N.; Dixit, S.; Levey, N.; Miller, K.; Dennis, W.; Atkinson, C.; & Broome, A-M. (2015) Immunosuppressive nanotherapeutic micelles blunt endothelial cell inflammation and immunogenicity in models of transplantation. RSC Advances: 5(54): 43552-62. [PMID: 26167278] Impact factor: 3.71
  11. Patel, K.J.; Atkinson, C.; Broome, A-M.; McGillicuddy, J.W.; Chavin, K.D.; & Nadig, S.N. (2015) Utilization of machine perfusion and nanotechnology for liver transplantation. Current Transplantation Reports. 2(4): 303-11.
  12. Perera R.H.; Solorio L.; Wu H.; Gangolli M.; Silverman E.; Hernandez C.; Peiris P.M.; Broome A-M.; & Exner A.A. (2014) Nanobubble ultrasound contrast agents for enhanced delivery of thermal sensitizer to tumors undergoing radiofrequency ablation. Pharmaceutical Research. 31(6): 1407-17. [PMCID: PMC3925199] Impact factor: 4.46
  13. Shukla, S.; Wen, A.M.; Ayat, N.R.; Commandeur, U.; Gopalkrishnan, R.; Broome, A-M.; Lozada, K.; Keri, R.A.; & Steinmetz, N.F. (2014) Biodistribution and tumor-homing properties of the filamentous plant virus nanoparticle potato virus X. Nanomedicine. 9(2): 221-35. [PMID: 23834501] Impact factor: 5.06
  14. Agnes, R.S.; Broome, A-M.; Kavik, K.; Verma, A.; Wang, J.; & Basilion, J.P. (2012) An optical probe for noninvasive molecular imaging of orthotopic brain tumors overexpressing epidermal growth factor receptor. Molecular Cancer Therapeutics. 11(10): 2202-11. [PMCID: PMC3829608] Impact factor: 5.23
  15. Perera, R.H.; Krupka, T.M.; Wu, H.; Traughber, B.; Dremann, D.; Broome, A-M.; & Exner, A.A. (2011) Role of pluronic block copolymers in modulation of heat shock protein 70 expression. International Journal of Hyperthermia. 27(7): 672-81. [PMCID: PMC3294295] Impact factor: 2.71
  16. Cheng, Y.; Meyers, J.D.; Agnes, R.S.; Doane, T.; Kenney, M.; Broome, A-M.*; Burda, C.*; & Basilion, J.P.* (2011) Addressing Brain Tumors with Targeted Gold Nanoparticles: A new gold standard for hydrophobic drug delivery. Small. 7(16): 2301-2306. [PMCID: PMC3837553] (*corresponding author) Impact factor: 6.17
  17. Harth, K.C.; Broome, A-M., Jacobs, M.R., Blatnik, J.A.; Zeinali, F.; Bajaksouzian, S.; & Rosen M.J. (2011) Bacterial clearance of biologic grafts used in hernia repair: an experimental study. Surgical Endoscopy. 25(7): 2224-9. [PMCID: PMC3148780] Impact factor: 3.44
  18. Cheng, Y.; Meyers, J.D.; Broome, A-M.*; Kenney, M.E.; Basilion, J.P.*; & Burda, C.* (2011) Deep penetration of a non-covalent PDT drug gold nanoparticle conjugate into tumors. Journal of American Chemical Society. 133(8): 2583-91 [PMCID: PMC3056176] (*corresponding author) Impact factor: 8.58
  19. Sandhu, G.S.; Solorio, L.; Broome, A-M.; Salem, N.; Kolthammer, J.; Shah, T.; Flask, C.; & Duerk, J.L. (2010) Whole animal imaging. Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 2(4), 398–421. [PMID: 20836038]
  20. Broome, A-M.; Bhavsar, N.; Ramamurthy, G.; Newton, G., & Basilion, J.B. (2010) Expanding the functionality of the classic -galactosidase complementation assay: piece by piece. Molecular Pharmaceutics 7: 60-74. Journal Cover Art. [PMCID: PMC2835542] (*corresponding author) Impact factor: 5.4
  21. Halaweish, I.; Harth, K.; Broome, A-M.; Voskerician, G.; Jacobs, M.R.; & Rosen, M.J. (2010) Novel in vitro model for assessing susceptibility of synthetic hernia repair meshes to Staphylococcus aureus infection using green fluorescent protein-labeled bacteria and modern imaging techniques. Surgical Infection 11(5): 449-54. [PMCID: PMC3155689] Impact factor: 1.65
  22. Eckert, R.L.; Sturniolo, M.T.; Broome, A-M.; & Rorke, E.A. (2005) Transglutaminases in Epidermis. In: Mehta, K. and Eckert, R. (eds): Transglutaminases: Family of Enzymes with Diverse Functions. Prog Exp Tum Res. Basel: Karger, 38, 115–124.
  23. Eckert, R.L.; Sturniolo, M.T., Broome, A-M., & Rorke, E.A. (2005) Transglutaminase function in epidermis. Journal of Investigative Dermatology 124: 481-92. [PMID: 15737187] Impact factor: 6.27
  24. Broome, A-M. and Eckert, R.L. (2004) Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor. Journal of Investigative Dermatology 122: 29-38. [PMID: 14962086] Impact factor: 6.27
  25. Editorial Commentary: Määttä, A. (2004) Roads to the edge of the cell: Intracellular transport of cornified envelope precursors. Journal of Investigative Dermatology 122: xii-xiii.
  26. Eckert, R.L.; Broome, A-M.; Ruse, M.; Robinson, N.; Ryan, D.; & Lee, K. (2004) S100 proteins in the epidermis. Journal of Investigative Dermatology 123: 23-33. [PMID: 15191538] Impact factor: 6.27
  27. Efimova, T.; Broome, A-M.; & Eckert, R.L. (2004) PKC regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38-ERK1/2 complex. Molecular Cell Biology 24: 8167-83. [PMCID: PMC515052] Impact factor: 6.19
  28. Broome, A-M.; Ryan, D.; & Eckert, R.L. (2003) S100 protein subcellular localization during epidermal differentiation and psoriasis. Journal of Histochemistry and Cytochemistry 51: 675-85. [PMCID: PMC3785113] Impact factor: 2.73
  29. Efimova, T.; Broome, A-M.; & Eckert, R.L. (2003) A regulatory role for p38 MAPK in keratinocyte differentiation:  evidence for p38-ERK1/2 complex formation. Journal of Biological Chemistry 278: 34277-285. [PMID: 12810719] Impact factor: 5.33
  30. Ruse, M.; Broome, A-M.; & Eckert, R.L. (2003) S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes. Journal of Investigative Dermatology 121: 132-41. Journal Cover Art. [PMID: 12839573] Impact factor: 6.27
  31. Sturniolo, M.; Dashti, S.R.; Deucher, A.; Rorke, E.A.; Broome, A-M.; Chandraratna, R.A.S.; Keepers, T.; & Eckert, R.L. (2003) A novel tumor suppressor protein promotes keratinocyte differentiation via activation of type I transglutaminase. Journal of Biological Chemistry 278: 48066-73. [PMID: 12928434] Impact factor: 5.33

Press Releases & Awards

  1. Medical University of South Carolina (2016, June). Nanotechnology as a Therapeutic Delivery Package. MUSC SCETV Health Focus Radio Shorts.
  2. Medical University of South Carolina (2016, Summer). Radical Ideas: The enduring promise of antioxidant therapy in cancer. ProgressNotes.
  3. National Innovation Award (2016, May). Targeted rapamycin micelle (TRaM) as a therapeutic in solid organ transplant. World TechConnect Conference.
  4. Scicasts (2016, May). Nanocarrier Provides Efficient Delivery of Chemotherapeutic Drug. Sci Nanomedicine.
  5. Medical University of South Carolina (2016, May). Molecular Imaging and Cancer Therapeutics. MUSC SCETV Health Focus Radio Shorts
  6. Medical University of South Carolina (2016, May). Tiny packages my pack powerful treatment for brain tumors. New sCenter & EurekAlert!
  7. Medical University of South Carolina (2015, Year in Review). Precision immunotherapy gets small. MUSC Health: Revealing Tomorrow.
  8. Medical University of South Carolina (2015, Spring). A Knockout Punch for Pediatric Brain Tumors?. ProgressNotes.
  9. Medical University of South Carolina (2014, Fall). Special Delivery: Personalized drug packaging to reduce organ rejection. ProgressNotes.
  10. Case Western Reserve University (2011, February 5). A loose grip provides better chemotherapy. Science Daily.
  11. Case Western Reserve University (2011, March 15). GOLD STANDARD: Hitching anti-cancer drugs to gold nanoparticles delivers faster, more effective treatment. Think.
  12. Case Western Reserve University (2011, March 3). CWRU researchers find improvements to chemotherapy drugs. NewsCenter.
  13. NIH/NIBIB Strategic Plan 2011 (2011, June 1). Developing the interdisciplinary skills of mid-career scientists.

© Medical University of South Carolina | Disclaimer