Warren Davis Jr, PhD
1998 Ph.D., University of Pennsylvania
Office: BSB 319E
The ATP-binding cassette transporter-2 and Alzheimer's disease.
A major focus of Dr. Davis' lab has been investigating the mechanisms regulating the proteolytic processing of the amyloid precursor protein (APP) into neurotoxic Abeta peptide fragments, which have been implicated in the etiology of Alzheimer's disease (AD). Current research has revealed that the ATP-binding cassette transporter-2 (ABCA2) is a key regulator of amyloid precursor protein metabolism. Recent epidemiological studies have identified a strong genetic link between ABCA2 and Alzheimer's disease. Future studies will investigate the role of ABCA2 in AD through in vivo ABCA2 knockout and transgenic mouse approaches.
Recent Publications | Additional Publications
1. Davis W Jr. The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells. Biochim Biophys Acta. 2011 Jul 23. [Epub ahead of print]
2. Davis, W. Jr. (2010) The ATP-Binding Cassette Transporter-2 (ABCA2) Increases Endogenous Amyloid Precursor Protein Expression and Abeta Fragment Generation. Curr. Alzheimer Res. 7:566-577.
3. Davis W Jr. The cholesterol transport inhibitor U18666a regulates amyloid precursor protein metabolism and trafficking in N2aAPP "Swedish" cells. Curr Alzheimer Res. 2008 Oct;5(5):448-56. PubMed PMID: 18855586.
4. Beljanski V, Soulika A, Tucker JM, Townsend DM, Davis W Jr, Tew KD. Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2). In Vivo. 2005 Jul-Aug;19(4):657-60. PubMed PMID: 15999530.
5. Tew KD, Boyd JT, Chen ZJ, Davis W Jr, Fazilev F, Findlay V, Gaté L, Ile K,Soulika A, Townsend DM. Glutathione and ABC transporters as determinants of sensitivity to oxidative and nitrosative stress. J Nutr. 2004 Nov;134(11):3205S-3206S. PubMed PMID: 15514308.