Perry Halushka, MD, PhD
Distinguished University Professor
Director, Medical Scientist Training Program
Member, Lipid Signaling in Cancer Program
Hollings Cancer Center
1967 Ph.D., University of Chicago
1970 M.D., University of Chicago
Office: BE 101
Molecular Characterization and Regulation of Thromboxane A2 Receptors in Health and Disease
The long term objective of our research program is to determine the role of thromboxane A2 receptors in disease processes with a particular emphasis in cancer. In collaboration with Drs. Omar Moussa and Dennis Watson we have found that there is an over-expression of the beta isoform of thromboxane A2 receptors in bladder cancer tissue and cell lines. The over-expression is associated with a poorer prognosis in patients with bladder cancer. Current studies are focused on determining the mechanisms for: 1) the over-expression of the receptors and 2) the signaling pathways involved in the oncogenic effects. The observations made in these studies may have wider applicability to other cancers.
Recent Publications | Additional Publications
1. Fan H, Li P, Zingarelli B, Borg K, Halushka PV, Birnbaumer L, Cook JA. Heterotrimeric Gα(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis. Biochim Biophys Acta. 2011 Mar;1813(3):466-72. Epub 2011 Jan 19. PMID: 21255617
2. Oates JC, Halushka PV, Hutchison FN, Ruiz P, Gilkeson GS. Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis. Am J Med Sci. 2011 Feb;341(2):101-5. PMID: 20924284
3. Fan H, Wong D, Ashton SH, Borg KT, Halushka PV, Cook JA. Beneficial Effect of a CXCR4 Agonist in Murine Models of Systemic Inflammation. Inflammation. 2011 Jan 28. [Epub ahead of print] PMID: 21274742
4. Fan H, Bitto A, Zingarelli B, Luttrell LM, Borg K, Halushka PV, Cook JA. Beta-arrestin 2 negatively regulates sepsis-induced inflammation. Immunology. 2010 May 4. [Epub ahead of print] PubMed PMID: 20465566.
5. Halushka PV, Krug EL. Is the training of biomedical scientists at a crossroads? Acad Med. 2009 Apr;84(4):421-3. PubMed PMID: 19318769.
6. Basher F, Fan H, Zingarelli B, Borg KT, Luttrell LM, Tempel GE, Halushka PV, Cook JA. beta-Arrestin 2: a Negative Regulator of Inflammatory Responses in Polymorphonuclear Leukocytes. Int J Clin Exp Med. 2008;1(1):32-41. Epub 2008 Jan 20. PubMed PMID: 19079685; PubMed Central PMCID: PMC2596334.
7. Moussa O, Ashton AW, Fraig M, Garrett-Mayer E, Ghoneim MA, Halushka PV, Watson DK. Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis. Cancer Res. 2008 Jun 1;68(11):4097-104. PubMed PMID: 18519668.