Perry Halushka, MD, PhD
Distinguished University Professor
Director, Medical Scientist Training Program
Member, Lipid Signaling in Cancer Program
Hollings Cancer Center
1967 Ph.D., University of Chicago
1970 M.D., University of Chicago
Office: BE 101
Molecular Characterization and Regulation of Thromboxane A2 Receptors in Health and Disease
The long term objective of our research program is to determine the role of thromboxane A2 receptors in disease processes with a particular emphasis in cancer. In collaboration with Drs. Omar Moussa and Dennis Watson we have found that there is an over-expression of the beta isoform of thromboxane A2 receptors in bladder cancer tissue and cell lines. The over-expression is associated with a poorer prognosis in patients with bladder cancer. Current studies are focused on determining the mechanisms for: 1) the over-expression of the receptors and 2) the signaling pathways involved in the oncogenic effects. The observations made in these studies may have wider applicability to other cancers.
Recent Publications | Additional Publications
1. Fan H, Goodwin AJ, Chang E, Zingarelli B, Borg K, Guan S, Halushka PV, Cook JA. Endothelial Progenitor Cells and a Stromal Cell-derived Factor-1α Analogue Synergistically Improve Survival in Sepsis. Am J Respir Crit Care Med. 2014 Jun 15;189(12):1509-19.
2. Li P, Neubig RR, Zingarelli B, Borg K, Halushka PV, Cook JA, Fan H. Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Gα(i2) protein. Inflammation. 2012 Oct;35(5):1611-7.
3. Moussa O, Ciupek A, Watson DK, Halushka PV. Urinary thromboxane B2 and thromboxane receptors in bladder cancer: opportunity for detection and monitoring. Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):41-4.
4. Li P, Cook JA, Gilkeson GS, Luttrell LM, Wang L, Borg KT, Halushka PV, Fan H. Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammation. Mol Immunol. 2011 Oct;49(1-2):64-74.
5. Fan H, Wong D, Ashton SH, Borg KT, Halushka PV, Cook JA. Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation. Inflammation. 2012 Feb;35(1):130-7.