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Current Faculty

John Hildebrandt, PhD

Hildebrandt PictureProfessor

1978         Ph.D., University of Iowa

Contact Info

Tel: 843-792-3209
Fax: 843-792-2475
Office: BSB 319A

Research Interests

Signal Transduction by GTP-binding Proteins

The Hildebrandt laboratory studies the structure and function of the heterotrimeric G proteins involved in mediating the effects of hormones and neurotransmitters on intracellular signaling pathways. We have particular interests in understanding the molecular mechanisms generating G protein subunit diversity and the relationship of this diversity to cellular regulation by multiple extracellular signals.

Recent Publications | Additional Publications

1: Rose KM, Wang Z, Magrath GN, Hazard ES, Hildebrandt JD, Schey KL. Aquaporin 0-calmodulin interaction and the effect of aquaporin 0 phosphorylation. Biochemistry. 2008 Jan 8;47(1):339-47. Epub 2007 Dec 15. PubMed PMID: 18081321.

2: Kilpatrick EL, Hildebrandt JD. Sequence dependence and differential expression of Ggamma5 subunit isoforms of the heterotrimeric G proteins variably processed after prenylation in mammalian cells. J Biol Chem. 2007 May 11;282(19):14038-47. Epub 2007 Mar 12. PubMed PMID: 17353195.

3: Wells CA, Dingus J, Hildebrandt JD. Role of the chaperonin CCT/TRiC complex in G protein betagamma-dimer assembly. J Biol Chem. 2006 Jul 21;281(29):20221-32. Epub 2006 May 15. PubMed PMID: 16702223.

4: Hildebrandt JD. Bring your own G protein. Mol Pharmacol. 2006 Apr;69(4):1079-82. Epub 2006 Jan 25. PubMed PMID: 16436587.

Book Chapters

1.  Hildebrandt, JD. Heterogeneous prenyl processing of the Heterotrimeric G Protein Gamma Subunits. The Enzymes-­‐Protein prenylation-­‐Volume 29 (ISBN 9780123813398), p97-­‐124, 2012, In press.


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