Department of Public Health Sciences
Alberg Senior on NMSC studies
|Dr. Anthony Alberg is Senior Author on Nonmelanoma Skin Cancer Manuscripts|
|Anthony Alberg is senior author of two manuscripts in press that are the first studies to investigate possible reasons why a personal history of nonmelanoma skin cancer (NMSC) is associated with increased risk of other malignancies.|
In a study of 5,900 participants, a thorough evaluation of single nucleotide polymorphisms (SNPs) in DNA repair pathway genes identified several noteworthy associations with the NMSC cancer-prone phenotype, with the strongest associations in two SNPs in the thymine DNA glycosylase (TDG) gene, a base excision repair gene recently discovered to play a central role in DNA de-methylation.
These results are in press in Carcinogenesis. In a separate report in press in Cancer Epidemiology, SNPs in hedgehog pathway genes were not observed to be associated with basal cell carcinoma of the skin or the cancer-prone phenotype.
Ruczinski I, Jorgensen TJ, Shugart YY, Berthier Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WHL, Wheless L, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of DNA repair gene variants in relation to nonmelanoma skin cancer as a marker of a cancer-prone phenotype. Carcinogenesis; 2012 (In press)
Jorgensen TJ, Ruczinski I, Shugart YY, Wheless L, Berthier Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WHL, Wheless L, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer. Cancer Epidemiology 2012; (In press)