Department of Public Health Sciences

Alberg Senior on NMSC studies

Dr. Anthony Alberg is Senior Author on Nonmelanoma Skin Cancer Manuscripts
Anthony Alberg is senior author of two manuscripts in press that are the first studies to investigate possible reasons why a personal history of nonmelanoma skin cancer (NMSC) is associated with increased risk of other malignancies.

In a study of 5,900 participants, a thorough evaluation of single nucleotide polymorphisms (SNPs) in DNA repair pathway genes identified several noteworthy associations with the NMSC cancer-prone phenotype, with the strongest associations in two SNPs in the thymine DNA glycosylase (TDG) gene, a base excision repair gene recently discovered to play a central role in DNA de-methylation.

These results are in press in Carcinogenesis. In a separate report in press in Cancer Epidemiology, SNPs in hedgehog pathway genes were not observed to be associated with basal cell carcinoma of the skin or the cancer-prone phenotype.

Ruczinski I, Jorgensen TJ, Shugart YY, Berthier Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WHL, Wheless L, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of DNA repair gene variants in relation to nonmelanoma skin cancer as a marker of a cancer-prone phenotype. Carcinogenesis; 2012 (In press)

Jorgensen TJ, Ruczinski I, Shugart YY, Wheless L, Berthier Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WHL, Wheless L, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer. Cancer Epidemiology 2012; (In press)

 
 
 

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