Department of Public Health Sciences
Society for Clinical Trials Selects the Emergency Medicine Study as 2012 Trial of the Year
One of the Data Collaboration Unit’s clinical trials was awarded 2012 Trial of the Year by the Society for Clinical Trials and had a plenary session at the annual meeting this May. Dr. Valerie Durkalski is the Statistical PI on the project. The study was published in NEJM last year (Rapid Anticonvulsant Medication Prior to Arrival Trial (RAMPART) (N Engl J Med 2012; 366:591-600, http://www.nejm.org/doi/full/10.1056/NEJMoa1107494 ).
The press release from the Society for Clinical Trials notes:
"The study (Silbergleit et al, New England Journal of Medicine, February 16, 2012), sponsored by the National Institute of Neurologic Disorders and Stroke, was conducted in children and adults using the emergency medical services system and a consent exception. As quoted from their publication, “This double-blind, randomized, noninferiority trial compared the efficacy of intramuscular midazolam with that of intravenous lorazepam for children and adults in status epilepticus treated by paramedics” and found “For subjects in status epilepticus, intramuscular midazolam is at least as safe and effective as intravenous lorazepam for prehospital seizure cessation.” This means that emergency medical technicians have a quicker and more practical way of treating this life-threatening seizure condition even before patients reach the hospital." http://www.sctweb.org/docs/mtg2013/TOTY%20press%20release%202013.pdf
Additional information can be found at the RAMPART study website: http://rampart.umich.edu/rampart/home