Skip Navigation

Public Affairs & Media Relations

MUSC in hypertension trial

Contact: Tony Ciuffo
(843) 792-2626   
CHARLESTON – The Medical University of South Carolina (MUSC) is the only medical center in South Carolina and the first site in the country to randomize a patient in the SYMPLICITY HTN-4 clinical trial intended to treat uncontrolled hypertension.

The trial investigates the efficacy and safety of the investigational Symplicity® renal denervation system in volunteers who have blood pressure between 140 and 160 mmHg and are unable to control their hypertension (high blood pressure) even when taking maximum tolerated doses of three or more blood pressure medications.

“We’re excited to participate in the SYMPLICITY HTN-4 trial,” said Thomas M. Todoran, M.D., Assistant Professor of Medicine, Director of Vascular Medicine at MUSC. “This investigational interventional treatment represents an innovative approach to treating the growing number of patients with uncontrolled hypertension in the United States.

“Renal denervation, along with ongoing treatment with antihypertensive medications, has the potential to help patients achieve their target blood pressure levels.”

Hypertension is an especially dangerous chronic disease because of its association with increased cardiovascular risk, including stroke and heart attack, as well as heart failure and kidney disease.

Renal denervation is an investigational catheter-based procedure that deactivates the nerves that line the walls of the arteries leading to the kidneys. These nerves are part of the sympathetic nervous system, which is one of the ways the body controls blood pressure. In people with hypertension, the renal nerves could be hyperactive, raising blood pressure and contributing to heart, kidney and blood vessel damage.
For more information regarding this clinical trial please visit

About MUSC
Founded in 1824 in Charleston, The Medical University of South Carolina is the oldest medical school in the South. Today, MUSC continues the tradition of excellence in education, research, and patient care. MUSC educates and trains more than 3,000 students and residents, and has nearly 13,000 employees, including approximately 1,500 faculty members. As the largest non-federal employer in Charleston, the university and its affiliates have collective annual budgets in excess of $1.7 billion. MUSC operates a 750-bed medical center, which includes a nationally recognized Children's Hospital, the Ashley River Tower (cardiovascular, digestive disease, and surgical oncology), Hollings Cancer Center (one of 66 National Cancer Institute designated centers) and a leading Institute of Psychiatry. For more information on academic information or clinical services, visit For more information on hospital patient services, visit




©  Medical University of South Carolina | Disclaimer