Description of Research Program
Identification of components in the diet which modulate carcinogenesis and understanding their mechanism of action. Identifying the enzymes that are responsible for the activation of carcinogens in humans and functional genetic polymorphisms of these carcinogen-metabolizing enzymes in order to establish their roles in human susceptibility to environmental carcinogenesis.
Selected Publications
Kim, S., Lee, M-J., Hong, J-I., Li, C., Smith, T.J., Yang, G-Y., Seril, D.N. and Yang, C.S. Plasma and tissue levels of tea catechins in rats and mice during chronic consumption of green tea polyphenols. Nutr. Cancer, 37: 41-48, 2000.
Smith, T.J. Squalene: potential chemopreventive agent. Exp. Opin. Invest. Drugs, 9: 1841-1848, 2000.
Su, T., Bao, Z., Zhang, Q-Y., Smith, T.J., Hong, J-Y. and Ding, X. Human cytochrome P450 CYP2A13: high efficiency in the metabolic activation of a tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and predominant expression in the respiratory tract. Cancer Res., 60: 5074-5079, 2000.
Smith, T.J. and Yang, C.S. Effect of organosulfur compounds from garlic and cruciferous vegetables on drug metabolism enzymes. Drug Metab. Drug Interact., 17: 23-49, 2000.
Yang, C.S., Chhabra, S.K., Hong, J-Y. and Smith, T.J. Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic. J. Nutr., 131: 1041S-1045S, 2001.
Hong, J., Smith, T.J., Ho, C-T., August, D.A. and Yang, C.S. Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. Biochem. Pharmacol., 62: 1175-1183, 2001.
Smith, T.J. Mechanisms of inhibition of carcinogenesis by isothiocyanates. Exp. Opin. Invest. Drugs, 10: 2167-2174, 2001.
Peng, G., Dixon, D.A., Muga, S.J., Smith, T.J. and Wargovich, M.J. Green tea polyphenol (-) epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. Mol. Carcinogenesis, in press, 2006. |
