Title:

Professor and Director of Professional Education

Education
Butler University, BS, 1979,
University of Florida, PhD, 1984

Description of Research Program
Dr. Soltis’ past research interests focused on the role of polyamine regulatory pathways (biosynthesis and transport) as essential components of the signal transduction mechanisms by which angiotensin II effects changes in the vasculature in hypertension.  Specifically, it is hypothesized that reciprocal alterations in the AT1 and AT2 subtypes of the angiotensin receptor mediate opposing actions of angiotensin II on vascular growth and function.

As the recently appointed Director of Professional Education in the department, Dr. Soltis expects to establish research activity in the area of educational and teaching initiatives in physiology/pathophysiology.

Selected Publications
    Soltis EE, Bohr DF.  Central action of sodium chloride on blood pressure and vascular responsiveness in the rat.  Hypertension, 8 (suppl. I): I-52-I-55, 1986.

    Soltis EE, Bohr DF.  Cerebral vascular responsiveness in the deoxycor­ticosterone acetate-salt rat.  Am. J. Physiol., 252:H198-H203, 1987.

    Soltis EE.  Effect of age on blood pressure and membrane-dependent vascular responses in the rat.  Circ. Res., 61:889-897, 1987.

    Soltis EE, Newman PS, Olson JW.  Polyamines, vascular smooth muscle and deoxycorticosterone acetate-salt hypertension.  Hypertension, 18:85-92, 1991.

    Piascik MT, Sparks MS, Pruitt TA, Soltis EE.  Evidence for a complex interaction between the subtypes of the ₁-adrenoceptor. Eur. J. Pharmacol., 199:279-289, 1991.

    Soltis EE.  Alterations in vascular structure and function after short-term losartan treatment in spontaneously hypertensive rats.  J. Pharmacol. Exp. Therap., 266:642-646, 1993.

    Piascik MT, Smith MS, Barron KW, Soltis EE.  The regulation of regional hemodynamics by ₁-adrenoceptor subtypes in the conscious rat. J. Pharmacol. Exp. Therap.,  267:1250-1255, 1993.

    Piascik MT, Smith MS, Soltis EE, Perez DM.  Identification of the mRNA for the novel a1d-adrenoceptor and two other a1-adrenoceptors in vascular smooth muscle.   Mol. Pharmacol., 46:30-40, 1994.

Piascik MT, Guarino RD, Smith MS, Soltis EE, Saussy DL, Perez DM.  The specific contribution of the novel alpha-_1d adrenoceptor to the contraction of vascular smooth muscle.  J. Pharmacol. Exp. Therap., 275:1583-1589, 1995.

Piascik MT, Soltis EE, Piascik MM, Macmillan LB.  a-Adrenoceptors and vascular regulation: molecular, pharmacologic and clinical correlates.  Pharmacology and Therapeutics, 72:215-241, 1996.

Lipke DW, Newman PS, Tofiq S, Guo H, Arcot SS, Aziz SM, Olson JW, Soltis EE.  Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension. Clin. Exp. Hypertension, 19:269-295, 1997.

Lipke DW, Newman PS, Tofiq S, Aziz SM, Soltis EE.  Eflornithine treatment alters changes in vascular responsiveness associated with coarctation hypertension.  Clin. Exp. Hypertension, 19:297-312, 1997.