Description of Research Program Cardiac ion channel protein function and regulation at normal and diseased conditions. Selected Publications Shryock J, Song YJ, Wang D, Baker SP, Olsson RA, Belardinelli L: Selective A2 adenosine receptor agonists do not alter action potential duration, twitch shortening, or cAMP accumulation in guinea pig, rat, or rabbit isolated ventricular myocytes. Circ. Res., 1993; 72: 194 205 Wang D and Belardinelli L: Mechanism of the negative inotropic effect of adenosine in guinea pig atrial myocytes. Am. J. Physiol., 1994; 267: H2420 29 Belardinelli L, Shryock JC, Song Y, Wang D, and Srinivas M: Ionic Basis of the Electrophysiological Action of Adenosine on ardiomyocytes.The FASEB Journal, 1995; 9: 359 65 (review) Wang D, Shryock JC, and Belardinelli L: Cellular basis for the negative dromotropic effect of adenosine on rabbit single atrioventricular nodal cells. Circ. Res., 1996; 78: 697 706 Wang D, Martens JR, Posner P, Sumners C, and Gelband CH: Angiotensin II regulation of intracellular culcium in astroglia cultured from rat hypothalamus and brainstem. J. Neurochem., 1996; 67:996 1004 Martens JR, Wang D, Sumners C, Posner P, and Gelband CH: Angiotensin II type 2 receptor mediated regulation of rat neuronal K+ channels. Circ. Res., 1996; 79:302 09 Wang D, Gelband CH, Sumners C and Posner P: Mechanisms underlying the chronotropic effect of angiotensin II on cultured neurons from rat hypothalamus and brain stem. J. Neurophysol. 1997; 78:1013-20 Wang D, Sumners C, Posner P, and Gelband CH: A type K+ channels in neurons cultured from neonatal rat hypothalamus and brain stem: Modulation by Angiotensin II. J. Neurophysol. 1997; 78:1021-29 Wang D and Armstrong DL: Tetraethylammonium potentiates the activity of muscarinic potassium channels in guinea pig atrial myocytes. J. Physiol. 2000; 529 Pt 3:699-705 Wang D, Hall SK, Rossie S, and Armstrong DL: A se/thr protein phosphatase couples muscarinic receptors to K+ channel stimulation in atrial myocytes. 2001; submitted to JBC |