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Psychiatry and Behavioral Sciences

MAP Study

Midlands Adolescent Project (MAP)
Stage II Research on Outpatient Treatment for Adolescents with Comorbidity

Adolescent substance abuse results in significant negative outcomes and extraordinary costs for youths, their families, communities, and society. Moreover, rates of psychiatric comorbidity among substance abusing youth range from 25% up to 82%, and youths with a dual diagnosis have worse outcomes and are more than twice as costly to treat than their counterparts with no comorbidity. This project evaluates the experimental treatment (OutPatient Treatment for Adolescents; OPT-A), a treatment that had promising results in NIDA-funded pilot testing, in a rigorous clinical trial. The intervention addresses one of the more prevalent and most challenging, costly, and understudied presenting problems among adolescent outpatients. If successful, this research could provide a considerable contribution in the treatment field for youth with co-occurring substance use and internalizing disorders.

The research is a Stage II randomized clinical trial (RCT) to compare the experimental treatment, OPT-A, to an "active placebo" (Treatment as Usual) on key clinical indices from pre-treatment through 18 months. The RCT (n = 160) employs the treatment manual, quality assurance protocol, and therapist training protocol developed and successfully piloted in the Stage I study, to evaluate the efficacy of OPT-A for youth referred to outpatient treatment of co-occurring substance use and internalizing problems. Specific aims include: (1) Determine the efficacy of OPT-A to reduce substance use among youth presenting for outpatient treatment of co-occurring substance use and internalizing disorders; (2) Determine the efficacy of OPT-A to improve mental health and functioning among youth presenting for outpatient treatment of co-occurring substance use and internalizing disorders; and (3) Examine consumer satisfaction for OPT-A. In addition to the main aims of the study, two exploratory aims will pursue preliminary mechanisms of action (MOA) research.

For more information, please contact Steve Shapiro (Project Manager) by phone at 843-876-1828, or by e-mail at


Disclaimer: Photos are being used for illustrative purposes only, and any person depicted is a model. Rights to all photos have been purchased.

Principal Investigator
Ashli J. Sheidow, Ph.D.

Jason E. Chapman, Ph.D.
Scott W. Henggeler, Ph.D.
Michael McCart, Ph.D.
Lisa Saldana, Ph.D.       

Funding Agency
National Institute on Drug Abuse (NIDA)

Project Number

Affiliated Centers/Programs
Lexington County Community Mental Health Center

Start Date - End Date
July 2009 - June 2014



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