After completing his PhD in Neuroscience and Behavior at the University of Paris XI, Dr. Grillon spent 5 years as a postdoc at the University of California, Irvine and then at the University of California, San Diego, where he studied attention dysfunction in schizophrenia. In 1988 he moved to Yale University where he became Associate Professor. There, he developed interests in anxiety and anxiety disorders, more specifically PTSD, using a translational approach. In 2000, Dr. Grillon moved to the National Institute of Mental Health in Bethesda, MD, to join the Mood and Anxiety Disorder program. He is a tenured track investigator, Section Chief, Neurobiology of Fear and Anxiety. His research focuses on understanding basic mechanisms of fear and anxiety and their dysfunction in anxiety disorders. He uses a multiperspective strategy based on psychophysiology to obtain objective measures of aversive states, psychopharmacology to identify defense mechanisms on which anxiolytics operate and to screen candidate anxiolytics, cognitive neuroscience to clarify the interaction between aversive states and cognitive processes, and neuroimaging to map the neural structures underlying fear and anxiety.