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Gene Function Core (GFC)

Gene Function Core


The Gene Function Core (GFC) was formed in January 2014 by the merger of two cores: the MUSC Transgenic Facility and the MUSC Gene Targeting Facility.

Its overall mission is to support investigators in the application of genetically modified mice or rats by providing the following services: (1) Expertise and technology required to generate DNA constructs for the production of genetically modified mice or rats; (2) Generation of genetically modified mice/rats by both “typical” transgenic and ES approaches, or CRISPR/Cas; (3) Sperm cryopreservation and strain rescue; and (4) Xenograft experiments for cancer researchers.

GFC supports investigators both within MUSC and external institutions.

The facility is located in BSB 638 (plasmid design, construction, purification and PCR optimization) and CRI 706 (transgenic, ES cell culture, gene targeting, and xenograft).

The GFC is supported by the COBRE Cardiovascular Developmental Biology Center (CDBC) and by the Office of the Vice President for Research as a University Research Resource Facility (URRF).

For internal users please see the list of services and fees, external users should contact the director.

Contact Information

Director: Michael J. Kern, Ph.D. Professor, Department of Regenerative Medicine and Cell Biology (

Co-Directors:  Alexander Awgulewitsch, Ph.D., Associate Professor Department of Rheumatology (

                         Demetri Spyropoulos, Ph.D. Professor, Department of Pathology (

Publication Acknowledgement

Any publication that used the resources of the Gene Function Core should contain the following wording in the acknowledgments section, “The Gene Function Core facility used for this work is supported by the Office of the Vice President for Research at the Medical University of South Carolina".


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