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Doing Research at MUSC

MUSC marks milestone with $27 million in COBRE grants

The Medical University of South Carolina is now home to four National Institutes of Health (NIH) Centers of Biomedical Research Excellence (COBRE), totaling more than $27 million .  COBRE is a component of the Institutional Development Award (IDeA) program, which encourages health-related research and supports faculty development and research infrastructure.

The Medical University was recently recognized for its outstanding research achievements with an unprecedented three simultaneous COBRE renewals in cardiovascular, oral health, and lipidomics research.

The COBRE for Oral Health Research (GRANT P30 GM103331) is focused on training a cadre of targeted researchers who will become established investigators and academic leaders in the continued development of the College of Dental Medicine's oral and craniofacial health research program.

Established in 2001, the COBRE in Cardiovascular Developmental Biology  (GRANT # P30 GM103342) is an active partnership between faculty at MUSC and the University of South Carolina (in Columbia, SC) to conduct fundamental studies of cardiovascular developmental biology and determine how these mechanisms can be applied to adult cardiovascular diseases and stem cell-based regenerative medicine.

The COBRE in Lipidomics and Pathobiology (GRANT # P30 GM103339) focuses on mentoring junior investigators to establish independent research programs on the role of bioactive lipids in human disease development and progression, including projects focused on cancer, neurodegeneration, and angiogenesis.

In 2011, the Medical University received a fourth COBRE award of $10.5 million to establish a Center in Oxidants, Redox Balance and Stress Signaling (GRANT # P20 GM103542).  The Center’s primary objective is to create a center of expertise in redox biology and stress signaling that plays such a critical role in a number of diseases including organ damage and cancer. 

In addition to developing a strong intellectual foundation in key targeted research areas, the COBRE awards also provide resources for acquiring and supporting a number of advanced technologies and equipment for the research and discovery programs. 

Dr. Stephen Lanier, Associate Provost for Research at MUSC commented that “The programmatic initiatives involving the Centers of Biomedical Research Excellence and related infrastructure development grants from the National Institutes of Health have simply been transformative for MUSC and have played important roles in the dramatic growth of research programs at the university over the last 10 years.”

“This Center of Biomedical Research Excellence exemplifies the impact of the Institutional Development Award (IDeA) program through its outstanding progress supporting exceptional science in cardiovascular biology and disease research, training and mentoring developing investigators, and building state-of-the-art research infrastructure,” said Fred Taylor, Ph.D., an IDeA program official at the National Institutes of Health’s National Institute of General Medical Sciences. “The next phase of support will enable the center to enhance and extend these activities, thereby continuing to make important contributions to improving research capacity and health in South Carolina, the region, and the nation."


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