Office of Research Integrity

Use of Hazardous Materials in Animals

There are many different types of research projects that might involve the use of potentially hazardous materials in animals. When hazardous materials pose more than minimal risk, DLAR provides BSL II containment in animal care rooms at various locations. As well, some investigator labs have authorization to use potentially hazardous agents and BSL II procedures.

The diverse categories of Hazardous Materials each have their own forms which must be approved by the respective regulatory authority and submitted as part of the IACUC application process. It is the PI's responsibility to obtain approvals and/or necessary signatures prior to submission. Incomplete applications will be referred back to the PI for appropriate permissions prior to approval.

Protocols involving the use of recombinant DNA, infectious agents, or selected biotoxins require the prior approval of the Institutional Biosafety Committee (IBC). All IBC-covered hazardous materials also require submission of the Biological Materials Appendix, approved through the Biosafety Officer. The Biological Materials Appendix alone is required for all other biological hazards.

Chemical agents must be approved through University Risk Management, using the Chemical Agents Appendix. They have a number of helpful resources, including the Occupational Safety Manual which lists several relevant policies. Typically, a Safety Data Sheet (SDS) for any chemical hazard is requested as part of the approval process.

Use of radioactive materials, other than fixed-site imaging equipment, requires approval from the Radiation Safety Committee (RSC) and approval of the Radiation Appendix by the Radiation Safety Officer.