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Division of Cardiothoracic Surgery

John S. Ikonomidis, MD, PhD

John S. Ikonomidis, MD, PhD
John S. Ikonomidis, MD, PhD

Associate Professor of Surgery

 John Ikonomidis, MD, PhD is the Horace G. Smithy Professor of Surgery and Chief of the Division of Cardiothoracic Surgery and is the Program Director. 

Dr. Ikonomidis graduated from the University of Toronto Medical School in 1989 and then entered the General Surgical Program at the University of Toronto from which he graduated in 1997. During this time, he also completed a PhD degree in cardiac physiology.  Following this training, Dr. Ikonomidis went to Stanford University where he completed Cardiothoracic Surgical training in June of 2000 and joined the faculty in the Division of Cardiothoracic Surgery at MUSC in July, 2000.  Dr. Ikonomidis’ clinical interests include thoracic aortic surgery and cardiopulmonary transplantation. Dr. Ikonomidis has developed the thoracic aortic surgical program at the Medical University of South Carolina which has experienced significant growth over the years. Currently, approximately fifty to sixty major thoracic aortic surgical procedures are performed annually. These procedures include valve –sparing aortic root replacement, aortic dissection repair, and endovascular stent grafting of the descending thoracic aorta. In addition, Dr. Ikonomidis serves as Surgical Director of the Cardiac Transplantation Program.

Dr. Ikonomidis’ research interests include myocardial protection and intraoperative interrogation of the myocardium for enzyme and signaling activity. In addition, Dr. Ikonomidis holds NIH grant funding for the study of a murine model of thoracic aortic aneurysms which has led to valuable insights with regard to the signaling and protease milieu present within the developing aneurysm. In addition, Dr. Ikonomidis holds NIH grant funding for the study of a multi-institutional ascending thoracic aortic aneurysm tissue bank, housed at MUSC, which is currently yielding valuable insights regarding the etiology of thoracic aortic aneurysms in patients with different risk factors.

Dr. Ikonomidis currently has over ninety-one publications either in print or in press. He is a member of the American Association for Thoracic Surgery, the Society of Thoracic Surgeons, the Western Thoracic Surgical Association, and the Southern Thoracic Surgical Association. In addition, he is a fellow of the American Heart Association, and is the Program Committee Chair for the AHA Council of Cardiovascular Surgery and Anesthesia. He currently serves as the guest editor for the Cardiovascular Surgical Supplement published each year by Circulation and is a member of the Editorial Board of The Journal of Thoracic and Cardiovascular Surgery. Dr. Ikonomidis currently serves on the Atherosclerosis and Inflammation in Cardiovascular Sciences Grant Study Section of the National Institute of Health.

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