South Carolina Investigators in Transplantation

Division of Transplant Surgery

South Carolina Investigators in Transplantation

The South Carolina Investigators in Transplantation (SCIT) is comprised of a group of basic science and translational investigators whose laboratories have a specific focus in transplant immunology. In South Carolina alone, there are approximately 1000 patients awaiting a life-saving organ. For over 20 years, the Medical University of South Carolina has offered comprehensive care to South Carolinians with end-stage organ disease. The fundamental goal of the SCIT is to investigate novel and innovative methods to better care for patients who are in need of or who have received an organ transplant. Through scientific research we are committed to “changing what’s possible.” 

Investigators

Links to Transplant-Related Journals

Links to Transplant-Related Societies

General Surgery Grand Rounds Schedule

Calendar of Events 

SCIT Calendar of Events

Satish N. Nadig, MD, PhD

Satish N. Nadig, M.D., Ph.D.
Assistant Professor, Surgery, Microbiology and Immunology

Dr. Nadig’s research focuses on immunoregulation and tolerance induction via novel drug delivery methods and use of regulatory T cells. Additionally, he is interested in humanized mouse models for pre-clinical in vivo assays.

Publication Search on PubMed 

Carl Atkinson, PhD

Carl Atkinson, Ph.D.
Associate Professor, Microbiology and Immunology

Dr. Atkinson’s research focuses on the interplay between the innate immune system and the development of adaptive anti-graft immune responses. His laboratory investigates the the role of complement in priming the adaptive immune response towards the graft at several key points in the transplantation process; brain death, ischemia reperfusion injury, acute and chronic rejection. In addition to understanding the mechanistic interplay between the complement system and the adaptive immune response a further focus of the laboratory is the development of targeted drug delivery systems to improve post transplant outcomes.

Publication Search on PubMed 

Zihai Li, MD, PhD

Zihai Li, M.D., Ph.D.
Professor & Chairman, Microbiology and Immunology

Dr. Li’s research focuses on the immunoregulation of the innate immune system focusing on heat shock proteins as well as toll-like receptors. Additionally, his lab also has an interest in harnessing the immunotherapeutic potential of pluripotent stem cells.

Publication Search on PubMed 

Stephen Tomlinson, PhD

Stephen Tomlinson, Ph.D.
Professor and Vice Chair for Research,  Microbiology and Immunology

Dr. Tomlinson’s research focuses on the biology of the complement system. A major focus is the role of complement in ischemia reperfusion injury and the modulation of adaptive immune responses.

Publication Search on PubMed 

Chenthamarakshan Vasu, PhD

Chenthamarakshan Vasu, Ph.D.
Associate Professor, Microbiology & Immunology

Dr. Vasu’s research focuses developing engineered dendritic cell and artificial antigen presenting cell based tolerogenic approaches for transplant rejection and autoimmunity. These studies are focused on inducing antigen specific regulatory T cells and target specific immune tolerance. His Lab also conducts studies to understand the influence of innate immune receptors and gut microflora in peripheral immune homeostasis and regulatory T cell function.  Ultimate goal of these studies is to develop novel immunotherapies using beneficial microbial components.

Publication Search on PubMed 

Kenneth D. Chavin, MD, PhD

Kenneth D. Chavin, M.D., Ph.D.
Professor, Vice Chair for Research Dept. of Surgery, Microbiology & Immunology

Dr. Chavin’s research focuses on innate immunity through TLR4 signaling and its effects on hepatic steatosis, the development of NASH, and ischemia-reperfusion.

Publication Search on PubMed 

Xue-Zhong Yu M.D., M.S.
Professor, Dept. of Microbiology & Immunology
Professor, Dept. of Medicine, Division of Hematology/Oncology

Dr. Yu’s research focuses on the biology of graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) after allogeneic hematopoietic stem cell transplantation (HSCT).  The ultimate goal of these studies is to prevent or treat GVHD while preserving the GVL effect, which could greatly enhance the therapeutic potential of HSCT.  Because T cells play central role to induce GVHD and mediate GVL effect, understanding T-cell response to allogeneic tissues versus tumor cells is critical for achieving this ultimate goal.  

Hongjun Wang, PhD
Associate Professor of Surgery

Dr. Wang’s research interest is islet biology, transplantation immunology in type 1 diabetes, and insulin signaling in obesity and type 2 diabetes. Her goal is to develop novel methods to increase the efficiency of islet transplantation and treatment of various types of diabetes.  

Kevin Staveley-O'Carroll, MD, PhD
Alice Ruth Reeves Folk Chair in Clinical Oncology
Professor and Chief in Oncologic & Endocrine Surgery and Microbiology & Immunology

Dr. Staveley-O'Carroll, along with Dr. Guangfu Li, have an NIH funded translational research laboratory which focuses on developing clinically useful therapeutic strategies for hepatocellular cancer (HCC). One particular aim is to elucidate cellular and molecular mechanisms by which chemotherapeutic agents prevent tumor-induced immune tolerance and enhance T cell-mediated immunotherapy of HCC. 

Links to Transplant-Related Journals

American Journal of Transplantation
http://www.amjtrans.com

Transplantation
http://journals.lww.com/transplantjournal

J. Heart Lung Trans.
http://www.jhltonline.org

Liver Transplantation
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1527-6473


Links to Transplant-Related Societies

The Transplantation Society
www.tts.org

American Society of Transplantation
www.asts.org

International Society of Heart & Lung Transplantation
www.ishlt.org

American Society of Transplantation
www.myast.org

 
 
 

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