Michael J. Yost, PhD

CURRENT TITLE:

Director of General Surgery Research, Associate Professor, Department of Surgery

EDUCATION:

Doctor of Philosophy in Chemical Engineering, May 1999.  Joint Biochemical Engineering program between the College of Engineering (Chemical Engineering) and the School of Medicine (Developmental Biology and Anatomy)

The University of South Carolina, Columbia, South Carolina 29208

Thesis: Design and Analysis of a Mechanical Cell Stimulator.  Advisors: Dr. Louis Terracio PhD (Medicine) and Dr. Harry J. Ploehn PhD (Engineering)

Master of Science in Chemical Engineering, June 1990.

Ohio University, Athens, Ohio 45701

Thesis: Modeling a Semi-batch Reactor Using a Neural-Network. Advisor: Dr. Kenneth Sampson PhD.

Bachelor of Science in Chemical Engineering, June 1985.

The Ohio State University, Columbus, Ohio 43210

PROFESSIONAL EXPERIENCE:

Medical University of South Carolina Charleston, South Carolina 29425 January 2012- Present

Director of General Surgery Research, Associate Professor, Department of Surgery

Appointments in Department of Surgery, Department of Regenerative Medicine and Clemson University Department of Bioengineering.

Responsible for all facets of the research effort in the Department of Surgery Division of General Surgery and Acute Care including: recruitment, personnel management, budget management and control, scientific direction, funding procurement, intellectual property identification and patent development,  negotiations and presentations with potential licensors of intellectual property, and management of multiple collaborative efforts within the University and other institutions and businesses.

University of South Carolina School of Medicine January 2000 –January 2012

Columbia, South Carolina 29208

Appointments in Department of Surgery, Chemical Engineering, and Cell Biology and Anatomy.

 Associate Professor of Surgery February 2009-January 2012

Director of Surgical Research        January 2003 – January 2012

Responsible for all facets of the research effort in the Department of Surgery including: recruitment, personnel management, budget management and control, scientific direction, funding procurement, intellectual property identification and patent development,  negotiations and presentations with potential licensors of intellectual property, and management of multiple collaborative efforts within the University and other institutions and businesses. 

Highlights:

·      Invented and developed a new extrusion device for producing collagen based tissue engineering scaffolds.  Device provides more in vivo like orientation to the scaffold fibers.

·      Co- inventor of a novel resuscitative fluid to treat severe hypovolemia.

·      Co-inventor of a novel method for determining resuscitation endpoint. 

·      Secured several multi-year funding grants from government and other public institutions as PI or as co- investigator in collaborative efforts.

Research Assistant Professor of Surgery January 2000- January 2003

Responsible for resident research training and the establishment of a research program within the Department of Surgery where none existed.  Transition from Industrial engineering to academic training responsibilities.   

Vitasol LLC Dec 2007 to present

Lexington SC 29072

Vice Chairman and Secretary, Vitasol Inc. November 2008 to present.

Vitasol LLC is a biotech startup company that specializes in novel resuscitative fluids and strategies.  Responsible for raising capital funds, supervision of scientific experimentation, creation of business plans and overall company operation.

Managing Partner Vitasol LLC Dec 2007 to 2008.

Devro-Teepak, Inc.      May 1991 – January 2000

PO Box 11925, Columbia, South Carolina, 29211

Process Development & Engineering Manager   June 1998 – January 2000.

Responsible for ten professional and nine hourly employees, development laboratory, and pilot plant. Responsible for management of a capital investment budget of $1,500k annually. 

Highlights:

·      Lead and completed the conception, development and installation of a $6,000k new technology process developed by our group.  The new process produces products that serve an existing market at a 30% lower cost of manufacture (new technology installation).

·      Redesigned glutaraldehyde treatment system to reduce process variability by 60%.

Process Development Manager     June 1996 - June 1998

Responsible for a ten person research and development department.  The department develops and evaluates new technology and new processes for the production of collagen based food casings consistent with Devro-Teepak business objectives. 

R&D Group Leader                January 1993 - June 1996

Responsible for a five-person research and development department for the production of collagen food casings.

Highlight: Developed a new product and process to produce collagen food casings to compete in the UK market.

Senior Development Engineer      January 1992 - January 1993

Responsible for research project execution.  Directed the activities of research technicians assigned to the project. 

Highlight:  Developed a new dryer design that is 50% more efficient than previous technology.

Development Engineer             May 1991 - January 1992

Responsible for research project execution.  Directed the activities of research technicians assigned to the project.

American Cyanamid Co.            1985 - 1991

Chemical Research Center, 1937 West Main St., Stamford, Connecticut 06904

Applications Engineer            December 1990 - May 1991

Responsible for new product and process development, and customer technical service.

Willow Island Plant, Willow Island, West Virginia

Technical Specialist             April 1988 - December 1990

Responsible for production technical support, new process development, quality management system, and environmental reporting for an eight million-lb./yr. isocyanate plant.  Member of a team responsible for evaluation of toll manufacturers to produce scale up quantities of new urethane products.

Highlights:  Developed a new batch process to produce polyurethane aqueous dispersions.  Developed the process and produced the product four months ahead of schedule for 50% of the original cost estimate.

 Process Engineer                  April 1986 - April 1988

Key member of the engineering team involved in the design, construction, and startup of a computer controlled multimillion dollar isocyanate plant.

Highlights:

·      Computer modeling of a reactor system resulted in a yield improvement of 18% and a waste reduction and cost savings of approximately $750,000 per year.

·      Worked as technical advisor for a new product production trial at Takeda Chemical Shimizu, Japan.  The trial successfully produced commercial quantities of the new product for test marketing.

Pilot Plant Shift Leader         July 1985 - April 1986

Shift leader of a pilot plant crew, responsible for supervision of pilot plant operations, maintenance, and reporting on plant performance.

PUBLICATIONS:

Journal Articles

1.     Hong Tan, Ph.D.; Stefanie Biechler; Lorain Junor; Michael J

Yost, Ph.D.; Delphine Dean, Ph.D.; Jinqing Li, Ph.D.; Jay D Potts, and Richard Goodwin, Fluid flow forces and rhoA regulate fibrous development of the atrioventricular valves Corresponding. Developmental Dynamics, In Press. 2012.

2.     Oliveira SM, Ringshia RA, Legeros RZ, Clark E, Yost MJ, Terracio L, Teixeira CC. An improved collagen scaffold for skeletal regeneration. J Biomed Mater Res A. 2010 Aug; 94(2):371-9.

3.     Amos JR, Li S, Yost M, Phloen H, Potts JD. Limb bud mesenchyme cultured under tensile strain remodel collagen type I tubes to produce fibrillar collagen type II. Biorheology. 2009 Jan;46(6):439-50.

4.     Pabon DF, Yost MJ, Melendez GC, Durand TM, Brock TZ, Felice PA, Campbell K, Bynoe RP, Fann SA. Novel bacterial immobilization compound effectively decreases bacterial counts in healthy volunteers. Am Surg. 2010 Jan;76(1):15-9.

5.     Valarmathi MT, Goodwin RL, Fuseler JW, Davis JM, Yost MJ, Potts JD. A 3-D cardiac muscle construct for exploring adult marrow stem cell based myocardial regeneration.  Biomaterials. 2010 Apr;31(12):3185-200. Epub 2010 Feb 2.

6.     Biechler SV, Potts JD, Yost MJ, Junor L, Goodwin RL, Weidner JW.  Mathematical modeling of flow-generated forces in an in vitro system of cardiac valve development.  Ann Biomed Eng. 2010 Jan;38(1):109-17. Epub 2009 Oct 28.

7.     Logan MS, Propst JT, Nottingham JM, Carpenter, CL, Goodwin RL, Terracio L, Yost MJ, Fann SA. Human Satellite Progenitor Cells for use in Myofascial Repair: Isolation and Characterization. Annals of Plastic Surgery, June, 2010.

8.     Propst JT, Terracio L, Fann SA, Yost MJ. The Role of Wound Healing and Inflammatory Mediators: Integration of Implanted Engineered Myofascial Constructs. Submitted: J. Of Investigative Surgery. April, 2009.

9.     Propst JT, Thiruvanamalai V, Goodwin RL, Lessner SM, Soder BL, Terracio L, Fann SA, Yost MJ. In vivo Investigation of Angiogenesis within Implanted Engineered Skeletal Muscle Tissue Grafts. In revision. Submitted: J. Of Investigative Surgery. Feb 2009.

10.  Morrison JE, Brizendine JB, Yost MJ, Fann SA., Massive ventral hernia with extensive heterotopic ossification: the honeycomb-abdomen. J Trauma. 2009 Apr; 66(4):1234-7.

11.  Norris RA, Potts JD, Yost MJ, Junor  L, Brooks T, Tan H, Hoffman S, Hart MM, Kern MJ, Damon B, Markwald RR, Goodwin RL. Periostin promotes a fibroblastic lineage pathway in atrioventricular valve progenitor cells. Dev Dyn. 2009 Mar 30.

12.  Soder BL, Propst JT, Brooks TM, Goodwin RL, Friedman HI, Yost MJ, Gourdie RG. The connexin43 carboxyl-terminal peptide ACT1 modulates the biological response to silicone implants. Plast Reconstr Surg. 2009 May; 123(5):1440-51.

13.  Nesbitt TL, Roberts A, Tan H, Junor L, Yost MJ, Potts JD, Dettman RW, Goodwin RL. Coronary endothelial proliferation and morphogenesis are regulated by a VEGF-mediated pathway. Dev Dyn. 2009 Feb; 238(2):423-30.

14.  A three-dimensional model of vasculogenesis. Valarmathi MT, Davis JM, Yost MJ, Goodwin RL, Potts JD.Biomaterials. 2009 Feb; 30(6):1098-112.

15.  Propst, John T., Fann, Stephen A., Franchini, Jessica L., Hansen, Karyn J. , Lessner, Susan M.,  Rose, John R., Terracio, Louis and Yost, Michael J. “Focused in vivo Genomic Analysis of Implanted Engineered Myofascial Constructs.” Journal of Investigative Surgery, Feb, 2009.

16.  Chaudry, W.,  Ashton, H.,  Muhamed A., Yost, MJ., Bull, S., and Daniel Frankel. Nanoscale viscoelastic properties of an aligned collagen scaffold. J Mater Sci: Mater Med DOI 10.1007/s10856-008-3574-3. Aug 2008.

17.  Propst, John T., Fann, Stephen A., Franchini, Jessica L., Hansen, Karyn J. , Lessner, Susan M.,  Rose, John R., Terracio, Louis and Yost, Michael J. “Focused in vivo Genomic Analysis of Implanted Engineered Myofascial Constructs.” Accepted Journal of Investigative Surgery, 2008.

18.  Propst, JT, Hansen, KJ, Yost, MJ, Morrison JE, and Fann, SA.  “Unique Recalcitrant Hernia Repair: Enterocutaneous Fistula with Complex Ventral Hernia.”  Accepted American Surgeon. January 2008.

19.  Valarmathi MT, Yost MJ, Goodwin RL, Potts JD. A three-dimensional tubular scaffold that modulates the osteogenic and vasculogenic differentiation of rat bone marrow stromal cells. Tissue Eng Part A. 2008 Apr; class="volume"14( class="issue"4): class="pages"491-504.

20.  Valarmathi MT, Yost MJ, Goodwin RL, Potts JD. The influence of proepicardial cells on the osteogenic potential of marrow stromal cells in a three-dimensional tubular scaffold. Biomaterials. 2008 May; class="volume"29( class="issue"14): class="pages"2203-16. Epub 2008 Mar 4.

21.  Rhett JM, Ghatnekar GS, Palatinus JA, Michael OQuinn M, Yost MJ, Gourdie RG. Novel therapies for scar reduction and regenerative healing of skin wounds. Trends Biotechnol. 2008 Apr; class="volume"26( class="issue"4): class="pages"173-80. Epub 2008 Mar 4. Review.

22.  Potts, JD, MJ Yost, G. Kaur, Q. Wang, T Valarmathi. A Tubular Scaffold that Modualtes differentiation of Rat Bone Marrow Stem Cells. Microscopy and Microanal 14(Suppl 2), 2008.

23.  Yan W, George S, Fotadar U, Tyhovych N, Kamer A, Yost MJ, Price RL, Haggart CR, Holmes JW, Terracio L. Tissue Engineering of Skeletal Muscle. Tissue Eng. 2007 Sep 19.

24.  Sutton MA, Ke X, Lessner SM, Goldbach M, Yost M, Zhao F, Schreier HW., Strain field measurements on mouse carotid arteries using microscopic three-dimensional digital image correlation.  J Biomed Mater Res A. 2007 Jul 2;

25.  Nesbitt, TL, PA Patel, MJ Yost, RL Goodwin, and JD Potts. A 3-D Model of Coronary Vessel Development. In Vitro CellDev.Biol-Animal 43:10-16. 2007.

26.  Potts, JD, T. Nesbitt, MJ Yost, and Richard Goodwin. Using Confocal Microscopy to Explore Cardiac Development and Disease. Microsc Microanal 13(Suppl 2), 2007.

27.  Franchini J, Cromer, G, Propst, J, and Yost, MJ. Novel Tissue Engineered Tubular Heart Tissue for in vitro Pharmaceutical Toxicity Testing Microsc Microanal. 2007 Aug;13(4):267-71.

28.  Friedman, HI, Giurgiutiu V., Bender, J., Crachiolo, G. and Yost, MJ.   " A biomechanical and morphologic analysis of capsule formation around implanted piezoelectric wafer active sensors in rats treated with cyclooxygenase-2 inhibition. Ann Plast Surg. 2008 Feb;60(2):198-203

29.  Wang, Xinnan, Yongda Yan, Michael J Yost, Stephen A Fann, Shen Dong and Xiaodong Li Nanomechanical Characterization of Micro/nanofiber Reinforced Type I Collagens J Biomed Mater Res A. 2007 Mar 23; [Epub ahead of print].

30.  Mironov V, Kasyanov VA, Yost MJ, Visconti R, Twal W, Trusk T, Wen X, Ozolanta I, Kadishs A, Prestwich GD, Terracio L, Markwald RR. Cardiovascular tissue engineering I. Perfusion bioreactors: a review.J Long Term Eff Med Implants. 2006;16(2):111-30.

31.  Nesbitt, T, A Lemley, J Davis, M J Yost, RL Goodwin, Jay D.  Potts. Epicardial Development in the Rat: A New Perspective. Microscopy and Microanalysis. 2006 Oct;12(5):390-8.

32.  SA Fann, Kosciusko, RD, Yost, MJ, Brizendine, JB, Blevins, WA, Sixta, SL, Morrison, JE, and Bynoe, RD. Use of Prognostic Indicators in the Development of a Statistical Model Predictive for Adrenal Insufficiency in Trauma Patients.  Am Surg. 2007 Mar;73(3):210-4.

33.  Morrison, JE, JB Brizendine, MJ Yost, and SA Fann.  Massive Ventral Hernia with Extensive Heterotopic Ossification: The Honeycomb Abdomen.  Accepted Journal of Trauma-Injury Infection & Critical Care. April 2006.

34.  Brizendine, JB, JF LeFaivre, MJ Yost, and SA Fann. Reconstruction of a Parasacral Hernia with Acellular Human Dermis Graft.  Hernia. 2006 Aug;10(4):360-3.

35.  Sweitzer, SM, SA Fann, TK Borg, JW Baynes, and MJ Yost. What is the Future of Diabetic Wound Care?  Diabetes Educator.  March/April 32 (2), 2006;197:210.

36.  Fann, SA, JL Franchini, L.Terracio, and Yost, MJ. A Model of Tissue Engineered Ventral Hernia Repair. J Invest Surg. 2006 May-Jun;19(3):193-205.

37.  Potts, JD, MJ Yost, RL Goodwin. Models of Cardiovascular Development: New Approaches are Making In Vitro En Vogue. Curr. Card Reviews. December 2005.

38.  Bender JW, Friedman HI, Giurgiutiu V, Watson C, Fitzmaurice M, and Yost MJ. The Use of Biomedical Sensors to Monitor Capsule Formation Around Soft Tissue Implants. Ann Plast Surg. 2006 Jan;56(1):72-77

39.  Wang, X., X. Li, and M. J. Yost Microtensile Testing of Collagen Fibrils for Cardiovascular Tissue Engineering, J Biomed Mater Res A. 2005 Aug 1;74(2):263-8.

40.  Yost, MJ, JL Franchini, RL Goodwin, T Nesbitt and J Potts, Tissue Engineered Heart Tube Using Embryonic Tissues, Microsc Microanal 11(Suppl 2), 2005.

41.  Yan, W, MJ Yost, RL Price, U Fotadar, S. George, L Terracio, Cell-Cell interaction in Engineered Cardiac Tissue, Microsc Microanal 11(Suppl 2), 2005.

42.  Yan, W., U. Fotadar, S. George, MJ Yost, R. L. Price, L. Terracio, Tissue Engineering of Skeletal Muscle, Microsc Microanal 11(Suppl 2), 2005.

43.  Potts, JD, C Wells, N. Turnipseed, T. Nesbitt, MJ Yost, RL Goodwin. Novel Approaches to the Study of cardiovascular Development. Microsc Microanal 11(Suppl 2), 2005.

44.  Goodwin, RL, T Nesbitt, RL Price, JC Wells, MJ Yost and JD Potts. 2004. A Three-Dimensional Model of Valvulogenesis. 2005 May;233(1):122-9.

45.  Joel Atance, MJ Yost, W. Carver Influence of the extracellular matrix on the regulation of cardiac fibroblast behavior by mechanical stretch (p NA).  J Cell Physiol. 2004 Sep;200(3):377-86.

46.  Boughey JC, MJ Yost, RP Bynoe Diabetes insipidus in the head-injured patient. Am Surg. 2004 Jun;70(6):500-3.

47.  Victor Giurgiutiu, Harold Friedman, Jonathan Bender, Thomas Borg, Michael J. Yost, William Newcomb, Amanda Black, Joel Bost, Christopher D. Stewart Electromechanical Impedance Sensor for In Vivo Monitoring the Body Reaction to Implants. J. of Investigative Surgery. September 2004.

48.  Friedman, H, C. Stonerock, and M. J. Yost. Use of Seprafilm® and INTERCEED® as a Barrier Film to Prevent Capsule Contracture.  J. of Investigative Surgery. September 2004.

49.  Yost, Michael J., C. F. Baicu, C. E. Stonerock, R. L. Goodwin, R. L. Price, J. M. Davis, H. Evans, P. D.  Watson, C. M. Gore, J. Sweet , L. Creech, M. R. Zile, and L. Terracio,  A Novel Tubular Scaffold for Cardiovascular Tissue Engineering. Tissue Engineering Vol. 10, 1/2 pp. 273-84, 2004.

50.  Evans, HJ, JK Sweet, RL Price, MJ Yost, and RL Goodwin. A novel 3-D Culture System for the Study of Cardiac Myocyte Development. Microsc Microanal 10(Suppl 2), 2004.

51.  Potts, JD, RL Price, MJ Yost, and RL Goodwin. Bioengineered Cardiac Development. Microsc Microanal 10(Suppl 2), 2004.

52.  Young HE, Duplaa C, Yost MJ, Henson NL, Floyd JA, Detmer K, Thompson AJ, Powell SW, Gamblin TC, Kizziah K, Holland BJ, Boev A, Van De Water JM, Godbee DC, Jackson S, Rimando M, Edwards CR, Wu E, Cawley C, Edwards PD, Macgregor A, Bozof R, Thompson TM, Petro GJ Jr, Shelton HM, McCampbell BL, Mills JC, Flynt FL, Steele TA, Kearney M, Kirincich-Greathead A, Hardy W, Young PR, Amin AV, Williams RS, Horton MM, McGuinn S, Hawkins KC, Ericson K, Terracio L, Moreau C, Hixson D, Tobin BW, Hudson J, Bowyer FP 3rd, Black AC Jr. Clonogenic analysis reveals reserve stem cells in postnatal mammals. II. Pluripotent epiblastic-like stem cells. Anat Rec A Discov Mol Cell Evol Biol. 2004 Mar;277(1):178-203.

53.  Henry E. Young,*, Cecile Duplaa, Marina Romero-Ramos, Marie-Francoise Chesselet, Patrick Vourc’h, Michael J. Yost, Kurt Ericson, Louis Terracio, Takayuki Asahara, Haruchika Masuda, Sayaka Tamura-Ninomiya, Kristina Detmer, Robert A. Bray, Timothy A. Steele, Douglas Hixson, Mohammad el-Kalay, Brian W. Tobin, Roy D. Russ, Michael N. Horst, Julie A. Floyd, Nicholas L. Henson, Kristina C. Hawkins, Jaime Groom, Amar Parikh, Lisa Blake, Laura J. Bland, Angela J. Thompson, Amy Kirincich, Catherine Moreau, John Hudson, Frank P. Bowyer III, T. J. Lin, and Asa C. Black Jr. Adult Reserve Stem Cells and Their Potential for Tissue Engineering Cell Biochemistry Biophysics, volume 40, pages 1-80, 2004.

54.  Boughey, J. C., C. J. Ewart, M.J. Yost, J. M. Nottingham, J. J. Brown. Chloride/Phosphate Ratio in Primary Hyperparathyroidism. The American Surgeon. 70(1): 25-28, Jan. 2004

55.  Stonerock CE. Bynoe RP. Yost MJ. Nottingham JM. Use of a vacuum-assisted device to facilitate abdominal closure.   American Surgeon. 69(12):1030-4; discussion 1034-5, Dec. 2003

56.  Price RL. Haley ST. Bullard TA. Goldsmith EC. Simpson DG. Thielen TE. Yost MJ. Terracio L.  Effects of platelet-derived growth factor-AA and -BB on embryonic cardiac development.   Anatomical Record. 272A(1):424-33, 2003 May.

57.  Evans HJ. Sweet JK. Price RL. Yost M. Goodwin RL.   Novel 3D culture system for study of cardiac myocyte development.   American Journal of Physiology - Heart & Circulatory Physiology. 285(2):H570-8, 2003 Aug.

58.  Bynoe RP. Kerwin AJ. Parker HH 3rd. Nottingham JM. Bell RM. Yost MJ. Close TC. Hudson ER. Sheridan DJ. Wade MD. Maxillofacial injuries and life-threatening hemorrhage: treatment with transcatheter arterial embolization. Journal of Trauma-Injury Infection & Critical Care. 55(1):74-9, 2003 Jul.

59.  Erickson, K., Nottingham, J. Yost, M. J., Primary Treatment of Pleural Effusions: VATS Poudrage Versus Tube Thoracostomy., American Surgeon. Vol. 68 (11), 2002 Nov.

60.  Parker, H., Nottingham, J., Yost, M. J., Bynoe, R. Laparoscopic Repair of Incisional Hernias., American Surgeon. Vol. 68 (6), pp 530-534, June 2002.

61.  Yost, M.J., R. L. Price, D. G. Simpson, and L. Terracio.  Artifical Myocardium: Design Principles and Substratum.  Microscopy and Microanalysis. 7 (suppl 2): pp. 138-139. 2001.

62.  Yost M. J., D. G. Simpson, K. Wrona, S. Ridley, H. Ploehn, T. Borg, L. Terracio.  Design and Construction of a Uniaxial Cell Stretcher., American Journal of Physiology, Heart and Circulatory Physiology., 279:H3124-H3130. 2000 Dec.

Book Chapters

1.     Michael J. Yost, Mary O. Morales, Veronica Rodriguez-Rivera and Louis Terracio Methods for the Isolation, Purification and Culture of Primary Skeletal Muscle Satellite Cells In: Wound Regeneration and Repair, Methods and Molecular Biology, ed. Robert Gourdie, in press, 2012.

2.     Stephen A. Fann, Mary O. Morales, Veronica Rodriguez-Rivera, Eric M. Yost, and Michael J. Yost, A Model System for Primary Abdominal Closures In: Wound Regeneration and Repair, Methods and Molecular Biology, ed. Robert Gourdie, in press, 2012.

3.     Ongstad E, Yost MJ, Goodwin RL,  Friedman HI, Fann SA, Ghatnekar GS  Gourdie RG. Regenerative Pharmacology of Implanted Materials and Tissue Engineered Constructs. In: Regenerative Pharmacology, (eds George Christ, Anthony Atala), in press.

4.     Ongstad EL, O’Quinn MP, Ghatnekar G, Yost MJ, Gourdie RG. A connexin43 mimetic peptide promotes regenerative healing and improves mechanical properties in skin and heart. Wound Repair and Regeneration, in press, 2011

5.     Price, RL, J Davis, MJ Yost, RL Goodwin, L Terracio. 2004. Electron Microscopy: It’s role in Imaging of Biomaterials and Engineered Cells and Tissues. In Encyclopedia of Biomaterials and Biomedical Engineering. G. Wnek and G. Bowin (eds). Marcel Dekker. Inc. pp534-542.

6.     Yost, M. J., Terracio, L, Price, R. L., Collagen Processing in Encyclopedia of Biomaterials and Biomedical Engineering. G. Wenek and G. Bowlin Editors;  Marcel Dekker, Inc. 2004.

7.     Yost, M. J., Stonerock, C. E., Gore, C. M., Ploehn H. J.,  Price R. L., Terracio, L., and Borg, T. K.  System for Producing Aligned Collagen Tissue Engineering Scaffolds; Biomedical Engineering:  Recent Developments.  J.  Vossoughi (Editor), ISBN: 1-930636-01-6 © 2002 Medical and Engineering Publishers, Inc, http://www.mepublishers.com

8.     Yost, M. J., Price, R. L., Simpson D. G., Yan, W., and Terracio, L.  Cardiac Tissue Engineering in Encyclopedia of Biomaterials and Biomedical Engineering; G. Wenek and G. Bowlin Editors; Marcel Dekker, New York 2002.

PATENTS:

1.     U.S. Patent No. 7,338,517. Issued 2007. Tissue Scaffold having Aligned Fibrils, Apparatus and Method for Producing same, and Artificial Tissue and Methods of Use Thereof.

2.     Canada patent No. 2,528,134 Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof. 

3.     12/072,150 Divisonal 1. Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof. 

4.     US Patent No. 7,727,441 Divisional 2.  Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof. 

5.     12/072,232 Divisonal 3. Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof. 

6.     US Patent No. 7,754,247 Novel Resuscitative Fluid. 

7.     12/722,915 Novel Resuscitative Fluid.

8.     Australia patent No. 20082605588 Novel Resuscitative Fluid.

9.     Europe Patent No. 08767894.2 Novel Resuscitative Fluid.

10.  Canada Patent No. 2,688,429 Novel Resuscitative Fluid.

11.  Novel Method for determining resuscitation endpoint.  Disclosure filed May 2008.  Patent application September 2008.

12.  Reaction Electrospun collagen for skeletal muscle tissue engineering.  Disclosure filed January 2012.

13.  Biofabrication of Novel collagen scaffolds using selective enzyme activity.  Disclosure filed January 2012.

CURRENT SUPPORT:

R01 NIH-NIDCR (Yost-PI). 2010-2014  $1,421,250

An Enabling Technology For Improving Engraftment of Implanted Materials and Cells.

The goal of this proposal is to investigate the use of novel peptides on scar formation and integration of tissue engineered constructs with native muscle.

NSF RII Bioprinting of a vascular tree. (Nagarkatti PI/ MJ Yost Co-Science Director and Thrust IV leader) 2009-2014 $20,000,000

PENDING SUPPORT:

NIH R21 HL087059-01 (Goodwin PI/Yost Co-PI) In vitro Development of Coronary Vessels $250,000

COMPLETED SUPPORT:

Viscofan Bioengineering (Yost-PI). $390,000

 cooperative research agreement                                                         04/2010-04/2012

NY State Stem Cell Initiative (Terricio PI/Yost Co-PI). $225,000    1/2009-12/2012

Skeletal Muscle Derived Stem Cells.

R01 NIH-NHLBI (Goodwin PI/Yost Co-PI). $1,250,000                 08/2007-07/2012

“A 3-D model system to study cardiac valve formation”

Experimental Program to Stimulate Competitive Research & Institutional Development (RII) Bridge Roger Markwald PI  M J Yost Co-PI. $200,000 2008-2009.

XLTECH Group Collagen Tube sponsored research (Yost PI) $90,000 2007-2009.

Vitasol LLC SC Launch phase II award (Fann/Yost co PIs) $200,000 2010.

Vitasol LLC Small Business SC Launch award (Fann/Yost Co PIs) $50,000 2007-2009.

R01 NIH-NIBIB DE014599 (Terracio PI/Yost Co-PI) $375,000     07/2004-06/2009

Tissue Engineering of  Skeletal Muscle

The goal of this project is to develop the technology to engineer skeletal muscle.

K25 NIH-NHLBI HL67097   Michael J. Yost (PI) $630,000           2001-2007

Mentored Quantitative Research Career Development Award

Mentor: Louis Terracio Ph. D.

Overall Goals: The goal of project is to transition my career from a practicing industrial engineering manager to a practicing Biomedical research engineer.  Further, the research goal of this project is to develop an artificial myocardium patch.   

NCC5-575/ H51-04    (Markwald PI/Yost co-PI) $45,000    07/1/2004 – 6/30/2006 

NASA EPSCoR                                                                                             

Cardiovascular Tissue Engineering

The goal of this project was to create a linear artificial heart tube.

Clinical Trials:

“Bacterial Immobilization.”  Funded by Adhezion Biomedical.  2006

TEACHING:

ECHE/BMEN 320 Introduction to Fluid Mechanics. 2010 to present

Cardiovascular Disease. Course Director Wayne Carver. Lectures include: Cardiovascular Physiology,  Cardiovascular Disease, and Engineering Solutions to Cardiovascular Problems. 2005 to present.

ECHE 589B: Topics in Biomedical Engineering. Course Director Jonathan Bender. Lectures include: Cardiovascular Physiology,  Cardiovascular Disease, and Engineering Solutions to Cardiovascular Problems. 2006 and 2007.

Laboratory: Suturing and Knot tying.  Course Director Michael J Yost PhD. 2006 to present.

EDITORIAL BOARD:

Associate Editor for Biomaterials Journal “Titanium” January 2008 to present

Editorial Board for “Annals of Plastic Surgery” December 2009 to2011

Reviewer for the following Journals:

Tissue Engineering

Microscopy and Microanalysis

American Journal of Physiology

Experimental Mechanics

In Vitro

Biomaterials

Biomedical Materials Research

Annals of Plastic Surgery

CONSULTANCIES:

2007 to present Consultant to Organogenesis Inc.  Specifically on Biomaterials and Collagen processing.

2008 to present Consultant to Devro-Teepak Inc.  Specifically on the Proper treatment and processing of collagen.

GRADUATE STUDENTS AND RESEARCH FELLOWS TRAINED:

Resident Research Fellows

Kurt Erikson, MD 2001-2002

Charles Stonerock, MD 2002-2003

Stephen Fann, MD 2002-2003

Scott Silver, MD 2003-2004

Judy Boughey, MD 2003-2004

William Newcomb, MD 2004-2005

Christopher Watson, MD 2005-2006

Brian Brizendine, MD 2006-2007

Sonny Jones, MD 2007-2008

Melissa Logan, MD 2007-2008

Diego Pabon-Romero, MD 2008-2009

Joel Bradley MD 2009-2010

Graduate Students

Veronica Rodriguez (PhD chemical engineering)  Current student projected graduation May 2013.

John Propst (PhD/MBA) PhD Dec 2008, MBA May 2010.  Biomedical Science/ Masters Business Administration. Newton Award for Graduate student Research, 2nd Place award USC Graduate Student Day research competition

Brent Soder MS.  Biomedical Science 2008.  Currently medical student Medical University of South Carolina

Graduate Student Committees

Stefanie Biechler PhD Biomedical Engineering 2012.

Andrea Franco-Roberts PhD Biomedical Science 2011.

Hong Tan PhD Biomedical Science. 2010.

Dana Ke PhD Mechanical Engineering. 2008.

Jennifer Amos PhD Chemical Engineering. 2008.

Adaris Aviles PhD Chemical Engineering.  2008.

Michael Aviles PhD Chemical Engineering. 2008.

Caroline Addis MS Biomedical Science 2007.

Joel Atance PhD Biomedical Science 2005.

J. P. Watson MS, Biomedical Science 2002.

Undergraduates and Medical Students

Alex Wagner Biomedical Engineering research intern 2010 to present

Gerry Koons Biomedical Engineering research intern 2010 to present

Jake McMillin  Summer research intern- School of Medicine Research Experience for Undergraduates

Sarah Holton Honors College Thesis Advisor

Daka Nanadu Summer research intern- School of Medicine Research Experience for Undergraduates

Jonathan Estrada Summer research intern- School of Medicine Research Experience for Undergraduates

Alex Zhang Undergraduate research experience

Connor McLaughlin Undergraduate research experience

Michelle Warren Summer research intern- School of Medicine Research Experience for Undergraduates

Karyn Hansen Medical student research rotation

Doug Gregorie Medical student research rotation

Ray Cromer Summer research intern- School of Medicine Research Experience for

Undergraduates

John Propst Undergraduate research experience- Currently completing a PhD in our lab.

Terra Thomas Honors College Thesis Co advisor

Amanda Willcox Summer research intern- School of Medicine Research Experience for Undergraduates

Thomas Chandler Undergraduate research experience

Robert Kosciusko Medical student research rotation

Reshma Changappa Undergraduate research experience

David Butts Undergraduate research experience

Latoya Jackson Summer research intern- School of Medicine Research Experience for Undergraduates

Neesha Desai Medical student research rotation

INVITED TALKS/ FEATURED PUBILCATIONS:

Featured Publications:

University of South Carolina, Breakthrough, Spring 2011

University of South Carolina, The Times, Spring 2010

University of South Carolina, Breakthrough, Spring 2010

University of South Carolina, Carolina Minutes, Spring/Summer 2010

University of South Carolina, The Carolinian, Spring 2008

University of South Carolina, The Carolinian,  Fall 2006

University of South Carolina, Breakthrough,  Gut Level Research Winter 2007

Invited Talks:

Grand rounds:

2010 Statistics I; Statistics II.

2009  Death Foretold, the use of Prognostic indicators in trauma; GAP junctions in wound healing. 

2008 Statistics I; Statistics II

2007 Statistics for the Clinician

2006 Designing a Research Project

2005 Statistics for the Clinician

2004 Designing a research project; Conducting Basic science research; Conducting Clinical Research.

INVITED TALKS:

TESI Sydney Australia.  Skeletal Muscle Tissue Engineering September 2010. 

Wake Forest Institute for Regenerative Medicine: Skeletal Muscle Tissue Engineering. June 2008.

NCTERM: Novel Approaches to Improving Wound Healing and Implant Tolerance. Sept 2007.

SC Bioengineering Conference: Novel Approaches to Improving Wound Healing and Implant Tolerance. June 2007.

American College of Surgeons: Statistics for the Clinician. Hilton Head, SC  May 2006

Innovention Conference: Tissue Engineered Repair of Ventral Hernia. Columbia, SC April 2006.

Science Café: Biomedical Engineering and Wound Healing.  Columbia, SC,  December 2006.

Foundation for Effective Wound Management: What is the Future of Wound Care? August 2006.

Microscopy and Microanalysis Society: Cardiovascular Tissue Engineering. Honolulu, Hawaii  July 2005.

 South Carolina Bioengineering Symposium:  A Novel Tubular Scaffold for Cardiovascular Tissue Engineering.  Columbia, SC  October 2004

Medical University of South Carolina: Tissue Engineered Heart Tube Using Embryonic Tissues Charleston, SC. November 2004.

NASA EPSCoR Conference: Engineered TWashington DC 2004.

Assisted Circulation Gordon Conference: Engineered Tubular Heart.  Big Sky, Montana.  2003.

COMMITTEES:

Search committee for Director of Cancer Research center and Surgical Oncologist

School of Medicine Space Utilization committee

School of Medicine Faculty Policies and Procedures Committee

Chairperson for PPN search committee member

Research Expansion Task Force committee member

Cell Biology and Anatomy search committee

Director of Neuroscience center search committee

Biomedical engineering faculty search committee

Chairman for regenerative medicine search committee member

Biomedical Undergraduate curriculum committee.

The School of Medicine Biomedical Engineering committee, committee Chairman.

REVIEW PANELS:

NIH MTE Study section 2011, 2012

NSF Panel for Biomaterials and Tissue Engineering 2007, 2006, 2005.

NIH Bioengineering Research Partnerships. 2005.

NIH study section SSSM (58) R21 review of Tissue Engineering grants.  August 2003