Department of Surgery
J. Matthew Rhett Research Overview
My work is aimed at elucidating the role that connexin channels play in ATP signaling during injuries. Our working hypothesis is that endothelial cells in the microvasculature near an injury release ATP, and attract inflammatory cell types to wounded tissue. Although inflammation is a necessary component of wound healing, inflammatory cells can cause tissue damage. Understanding the molecular mechanisms behind this process could lead to therapies directed at dampening the inflammatory response during wound resolution.
Rhett, et al. 2014 Tissue Engineering Part B