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Training in Craniofacial and Oral Health Research

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 T-COHR | PhD in Biomedical Sciences | Craniofacial Biology

Craniofacial Biology Faculty

W. Scott Argraves, Ph.D.
Professor
Cell Biology & Anatomy
Extracellular matrix (ECM) signaling in development and disease. One ECM protein being studied is fibulin-1. Investigators in the Argraves lab have found that mice deficient in fibulin-1 recapitulate many of the phenotypes associated with 22q11 deletion/DiGeorge syndrome (DGS), which occurs with a frequency of 1:4000 human births. The spectrum of malformations observed in fibulin-1
nulls is consistent with fibulin-1 playing a critical role in the migration and survival of cranial neural crest cells. Studies are ongoing to determine the signaling pathways involved in craniofacial morphogenesis that are regulated by fibulin-1.


Lauren E. Ball , Ph.D.
Assistant Professor
Pharmacology
Diabetic Complications in Periodontal Ligament and Alveolar Bone

Amy Bradshaw, Ph.D.
Assistant Professor
Division of Cardiology, Department of Medicine
Cellular mechanisms that control extracellular matrix turnover, particularly collagen fibers, in the periodontal ligament in both healthy and diseased tissues
 
Angela Chi, D.M.D.
Assistant Professor
College of Dental Med/Stomatology
Tobacco-related oral carcinogenesis, cytochrome p450 metabolism

Terry A. Day, M.D.
Professor
Otolaryngology - Head & Neck Surgery
Novel therapies in the treatment of head and neck cancer; Molecular markers in the diagnosis and treatment of head and neck cancer; Quality of life and functional outcomes in head and neck cancer

M. Boyd Gillespie, M.D., M.S., FACS
Associate Professor
Otolaryngology - Head & Neck Surgery
Human papillomavirus-associated head and neck cancer, sleep apnea, iatrogenic xerostomia prevention

Monika Gooz, M.D., Ph.D
Assistant Professor
Department of Medicine
Role of ADAMs in inflammation and tumorigenesis

Courtney J. Haycraft, Ph.D.
Assistant Professor
Division of Nephrology, Department of Medicine
Cilia function in bone development and homeostasis, cilia function in tooth patterning and morphogenesis, signal transduction pathway regulation

Yan Huang, M.D., Ph.D.
Professor
Division of Endocrinology, Diabetes and Medical Genetics
Department of Medicine
Pathogenesis of periodontal disease in diabetes with a focus on inflammation
 
Michael J. Kern, Ph.D.
Associate Professor
Cell Biology & Anatomy
Defining the molecular/genetic circuitry in bone and orofacial development and regeneration

Keith Kirkwood, Ph.D.
Associate Dean for Research, Associate Professor
College of Dental Medicine
Periodontal Inflammation and Bone Loss

Robin C. Muise-Helmericks, Ph.D.
Associate Professor
Angiogenesis as it pertains to normal vessel development, tumor vascularization and wound healing focusing on the role of the Akt family of kinases

Anna-Liisa Nieminen, Ph.D.
Associate Professor
Pharmaceutical Sciences
Photodynamic therapy of head and neck cancers, special emphasis on the interplay between lysosomes and mitochondria. Cell and molecular imaging
 

James S. Norris, Ph.D.
Chair, Department of Microbiology and Immunology
Head and neck cancer and prostate cancer gene therapy, small molecule inhibitors of sphingolipid metabolism

Hong Yu, M.D.
Research Assistant Professor
Department of Craniofacial Biology
The role of lipid rafts in periodontitis and oral cancer progression. Sphingolipids therapies for periodontitis and oral cancer

Besim Ogretmen, Ph.D.
Associate Professor
Biochemistry and Molecular Biology
Roles and mechanisms of action of sphingolipid metabolism and signaling in the regulation of human head and neck cancer pathogenesis and therapy

Visu Palanisamy, Ph.D.
Assistant Professor
Craniofacial Biology
Regulation of mRNA stability mechanisms in oral cancer
 

Chris H. Parsons, M.D.
Assistant Professor
Infectious Diseases Division
HIV/AIDS, viral malignancies

Sakamuri V. Reddy, Ph.D.
Professor
Pediatrics
Our objectives are to understand normal and pathologic bone remodeling with a focus on osteoclast and osteoblast cell development/function in the bone micrenvironment. First, we are interested in studying pathobiology and development of novel therapeutic agents against bone diseases such as Paget's disease of bone, osteopetrosis, spinal muscular atrophy (SMA) and bone loss under microgravity conditions in space. Second, to unravel the molecular mechanisms and prevention of tumor osteolysis associated with cancer types such as oral squamous cell carcinoma (OSCC), prostate cancer, multiple myeloma, osteosarcoma and giant cell tumor of bone (osteoclastoma)

Susan G. Reed, DDS, DrPH
Associate Professor
College of Dental Medicine
Vitamin D in oral health and disease, Oral cancer epidemiology

Steven A. Rosenzweig, Ph.D.
Professor
Department of Pharmacology

Michael Schmidt, Ph.D.
Professor
Microbiology & Immunology
Bacterial pahtogenesis, controlling acquisition of hospital infections, indigenous microflora and their role in chronic diseases

Natalie A. Sutkowski, Ph.D.
Assistant Professor
Microbiology & Immunology
Viral-associated head and neck cancers

Dennis Watson, Ph.D.
Professor
Biochemistry and Molecular Biology
Molecular genetics and regulation of cancer

Xuejun Wen, M.D., Ph.D.
Assistant Professor
Clemson-MUSC Bioengineering Program
Novel biomaterials, stem cell biology, cell/tissue engineering, regenerative medicine, nanotechnology, controlled drug delivery/release
 
Caroline Westwater, Ph.D.
Assistant Professor
Department of Craniofacial Biology
Candida pathogenesis; Fungal quorum sensing; Fungal oxidative stress resistance; Plant-derived antimicrobials; Indigenous microflora and their role in chronic diseases

Hai Yao, Ph.D.
Assistant Professor
Clemson-MUSC Bioengineering Program
Cartilage mechanics and mechanobiology, Functional tissure engineering, Molecular imaging

M. Rita Young, Ph.D.
Professor
Otolaryngology - Head and Neck Surgery
Mechanisms by which tumors suppress anti-tumor immune defenses and developing approaches to overcome this tumor-induced immune dysfunction

 

Scholars Day