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Training in Craniofacial and Oral Health Research

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 T-COHR | T-COHR Trainees | Justin McAbee

Student Profiles-Justin McAbee

Project Title: 

Sexual Dimorphism in Periapical Inflammation and Bone Loss from MAP Kinase Phosphatase-1 Deficient Mice

Project Description:

Mitogen Activating Protein (MAPK) kinase phosphatase-1 (MKP-1) has been shown to be a key negative regulator of the MAP kinase pathways of the innate immune system.  The impact of MKP-1 in an endodontic model has yet to be studied.  Thus, the purpose of this study was to determine the role of MKP-1 in a bacterial-driven model of pathological endodontic bone loss.

American Association of Endodontists Foundation grant recipient

Above entitled project accepted for publication in Journal of Endodontics

Mentor and Department

Dr. Keith Kirkwood DDS, PhD
Medical University of South Carolina