Student Profiles-Xiaoyi Tina Zhang
4th year student
Title of Project
The role of MKP-1 in tumor-associated inflammation.
Brief description of project
In numerous malignancies, MKP-1 expression is down-regulated compared to normal tissues. As a MAP kinase phosphatase, MKP-1 serves as a key negative regulator of innate immune responses. We propose MKP-1 modulates tumor-associated inflammation and are investigating its regulatory role in the oral cancer microenvironment.
Mentor and Department
Dr. Keith Kirkwood DDS, PhD
Medical University of South Carolina
X. Zhang, J.A. Stewart, Jr., I.D. Kane, E.P. Massey, D.O. Cashatt, and W.E. Carver. Effects of elevated glucose levels on interactions of cardiac fibroblasts with the extracellular matrix. In Vitro Cellular & Development Biology – Animal. 2007. 43(8-9):297-305.
T.H. Beckham, P. Lu, J.C. Cheng, D. Zhao, L.S. Turner, X. Zhang, K.E. Armeson, A. Liu, S.T. Marrison, Y.A. Hannun, and X. Liu. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012, doi: 10.1002/ijc.27480.
X. Zhang, C.Rossa, Jr., M. Liu, F. Li, N.J. D’Silva, and K.L. Kirkwood. Oral squamous carcinoma cells secrete RANKL directly supporting osteolytic bone loss. Oral Oncology. Submitted for review.
Honors and Awards
MUSC MSTP Lane Family Scholarship, 2008
University Medical Associates Medical Scientist Training Program Award, 2008
American Medical Association Seed Grant Recipient, 2012
MUSC 9th Annual Head and Neck Multidisciplinary Research Workshop, Oral presentation, 2nd place, 2011
MUSC Perry V. Halushka Student Research Day, Oral presentation, 2nd place, 2011
MUSC 10th Annual Head and Neck Multidisciplinary Research Workshop, Oral presentation, 1st place, 2012