Skip Navigation
Medical University | MUSC Hospital | Directory | A-Z Index

Training in Craniofacial and Oral Health Research

MUSC logo

 T-COHR | T-COHR Trainees | Greg Wright
Student Profiles-Greg Wright
3rd year student

Title of Project                

Biomechanical Characterization and Modeling of Human TMJ Disc

Project Description

In patients with TMD, over 70% suffer from disc displacement and derangement due to degeneration of the TMJ disc with possible origins linked to pathological mechanical loading. Through earlier findings within our lab, we have developed an initial hypothesis that mechanical strain affects diffusivity and nutrient transport ability within the TMJ disc. Further, the loss of nutrients through mechanical injury and subsequent catabolic changes in the disc may result in degeneration. Currently, I am working to characterize the mechanical and transport properties of the human TMJ disc for my PhD. project. The significance for this study is that while the human knee and IVD cartilage has been well characterized, this will be the first study to characterize the mechanical properties of the human TMJ using healthy tissue. I will use the fundamental material properties along with joint motion to develop a TMJ disc finite element model to better understand the in vivo loading environment. Completion of this project may provide significant impact to the field to elucidate the mechanical role of the TMJ disc in TMJ disorder, from understanding the cellular environment to many finite element material models that examine stress profiles in the disc related to pathological loading.

Mentor and Department

Dr. Hai Yao
Department of Bioengineering, Clemson-MUSC Joint Bioengineering Program
Medical University of South Carolina 

Publications

Wright GJ, Kuo J, Bacro, TH, Slate EH, and Yao H. Effect of Mechanical Loading on Electrical Conductivity in Human TMJ Discs Is Sex-dependant. Journal of Dental Research, 2012 (in review)

Brockbank KG, Rahn E, Wright GJ, Chen Z, Yao H. Impact of Hypothermia upon Chondrocyte Viability and Cartilage Matrix Permeability after 1 Month of Refrigerated Storage. Transfusion Medicine and Hemotherapy, 2011 Dec. 38(6): p. 387-392.

Kuo J, Wright GJ, Bach DE, Slate EH, Yao H. Effect of mechanical loading on electrical conductivity in porcine TMJ discs. Journal of Dental Research. 2011 Oct: 90(10): p. 1216-20.

Brockbank, KGM, Wright, GJ, Yao, H, Greene, ED, Chen, ZZ, Schenke-Layland, K. Allogeneic heart valve preservation – A novel storage method above the glass transition phase change. The Annals of Thoracic Surgery, 2011 Apr. 30

Meetings attended

1)Oral Presentation Siegling Society Research Day April 26th, 2012. Department of Orthopaedic Surgery Medical University of South Carolina, Charleston, SC

Management of Kyphotic Deformity Associated with Early Onset Scoliosis: A

Biomechanical Comparison of Different Methods 

Greg Wright, Alaa Ahmad, Richard Gross, and Hai Yao

2) Oral Presentation The 41st Annual Meeting of the American Association for Dental Research March 21-24, 2012. Tampa, FL

Glucose and lactate diffusion in porcine TMJ disc

Jonathan Kuo, Greg Wright, Michael Kern, and Hai Yao

3) Oral Presentation The 40th Annual Meeting of the American Association for Dental Research March 16-19, 2011. San Diego, CA,

Mechanical Strain Affects Electrical Conductivity in Human TMJ Discs

Greg Wright, Jonathan Kuo, Thierry Bacro and Hai Yao

4) Oral Presentation The 40th Annual Meeting of the American Association for Dental Research March 16-19, 2011. San Diego, CA,

Biomechanical characterization of porcine retrodiscal tissue

Jonathan Petersen, Greg Wright, and Hai Yao

5) Oral Presentation The 19th International Congress of the European Association of Tissue Banks November 3-5, 2010.  Berlin, Germany

Impact of hypothermia upon chondrocyte viability and cartilage matrix permeability during one month of refrigerated storage

Kelvin Brockbank, Rahn E, Greg Wright, Chen Z, Hai Yao

6) Poster The 39th Annual Meeting of the American Association for Dental Research March 3-6, 2010, Washington, DC

Strain-dependent regional electrical conductivity of porcine TMJ disc tissue

Jonathan Kuo, Greg Wright, and Hai Yao

7) Poster 2nd Annual Scholar’s Day February 23rd, 2012. MUSC Department of Dental Medicine Medical University of South Carolina, Charleston, SC.

Mechanical Strain Affects Conductivity in Human TMJ Discs

Greg Wright, Jonathan Kuo, Thierry Bacro and Hai Yao    

 
 

Scholars Day