Title of Project
The role of extracellular heat shock protein 90 in Kaposi’s sarcoma-associated herpesvirus pathogenesis
Brief description of project
My current research focuses on signaling events related to the pathogenesis of Kaposi’s sarcoma-associated herpesvirus, a major cause of oral cancer in immunocompromised patients
Mentor and Department
Chris H. Parsons, MD
Medical University of South Carolina
NIH Ruth L. Kirschstein National Research Service Award Recipient
MUSC Presidential Scholar (2012-2013)
2010 Qin Z, DeFee M, Isaacs JS, Parsons C. Extracellular Hsp90 serves as a cofactor for
MAPK activation and latent viral gene expression during de novo infection by KSHV.
Virology. 2010; 403(1): 92-102. This publication was nominated for a Faculty
of 1000 award
2011 DeFee MR, Qin Z, Dai L, Toole BP, Isaacs JS and Parsons CH. Extracellular Hsp90
serves as a co-factor for NF-kB activation and cellular pathogenesis induced by an
oncogenic herpesvirus. Am J Cancer Res 2011; 1(5): 686-699
2011 DeFee M, Qin Z, Dai L, Isaacs JS, Parsons C. Am J Cancer Res 2011. Interactions
between Hsp90 and oncogenic viruses implications for viral cancer therapeutics.
Am J Cancer Res 2011;1(6):763-772
2012 Dai L, Qin Z, DeFee M, Toole B, Kirkwood KL, Parsons C. Kaposi sarcoma-associated
herpesvirus (KSHV) induces a functional tumor-associated phenotype for oral fibroblasts.
Cancer Lett 2012; 318(2):214-20