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Training in Craniofacial and Oral Health Research

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 T-COHR | T-COHR Trainees | Michael DeFee

Student Profiles- Michael DeFee
2nd year DMSTP student


Title of Project

The role of extracellular heat shock protein 90 in Kaposi’s sarcoma-associated herpesvirus pathogenesis     

Brief description of project 

My current research focuses on signaling events related to the pathogenesis of Kaposi’s sarcoma-associated herpesvirus, a major cause of oral cancer in immunocompromised patients

Mentor and Department        

Chris H. Parsons, MD
Medical University of South Carolina

Honors/Awards Received

NIH Ruth L. Kirschstein National Research Service Award Recipient

MUSC Presidential Scholar (2012-2013)


2010   Qin Z, DeFee M, Isaacs JS, Parsons C. Extracellular Hsp90 serves as a cofactor for
          MAPK activation and latent viral gene expression during de novo infection by KSHV.
          Virology2010; 403(1): 92-102. This publication was nominated for a Faculty
          of 1000 award
2011    DeFee MR, Qin Z, Dai L, Toole BP, Isaacs JS and Parsons CH. Extracellular Hsp90
           serves as a co-factor for NF-kB activation and cellular pathogenesis induced by an
           oncogenic herpesvirus. Am J Cancer Res 2011; 1(5): 686-699
2011    DeFee M, Qin Z, Dai L, Isaacs JS, Parsons C. Am J Cancer Res 2011. Interactions
           between Hsp90 and oncogenic viruses implications for viral cancer therapeutics.
           Am J Cancer Res 2011;1(6):763-772
2012    Dai L, Qin Z, DeFee M, Toole B, Kirkwood KL, Parsons C. Kaposi sarcoma-associated
           herpesvirus (KSHV) induces a functional tumor-associated phenotype for oral fibroblasts.
           Cancer Lett 2012; 318(2):214-20