Targeting CD26hi T-cells for Cancer Therapy
Inventors at MUSC have identified a unique human CD4+ T cell population that expresses high levels of surface CD26, termed CD26high T cells, which mediate durable antitumor immunity in vivo, and have immediate clinical relevance for designing new vaccines and cellular therapies.
CD26high T cells simultaneously secrete elevated IL-17A, IFN-? and IL-22 compared to Th1, Th2 or Th17 cells. When infused into mice bearing human tumors, CD26high T cells more efficiently reconstituted immunodeficient hosts and persisted long-term compared to other subsets. Remarkably, CD26high T cells engineered with a first generation CD3? mesothelin-specific chimeric antigen receptor (CAR) were capable of ablating large human mesothelioma tumors when infused into mice.
Spinal Implant System for Reduction & Internal Implant Stabilization of Human Spondylolisthesis Deformity
The Hercules spinal implant device and system is to be used for reduction and internal implant stabilization of human vertebral spondylolisthesis deformity. It is a standalone system with unique design that allows an anterior surgical approach to realign and simultaneously stabilize the spinal vertebral segments while protecting and preserve nerve function and not damaging other human body visceral anatomy in order to correct all grades of spondylolisthesis. The proposed solution is to use two implants in the interbody space, allowing greater flexibility to handle high grades of spondylolisthesis that utilize a locking mechanism when the spine has returned to proper alignment to provide the same stability as that of a single implant. Additionally, the reduction system used to realign the spine is designed to minimize the physical strain of the surgeon while realigning the spine, which could have high resistive forces in high grades of spondylolisthesis. This spinal reduction system is able to treat any grade of spondylolisthesis without supplemental fixation. This is used to treat patients with the spondylolisthesis deformity that causes extreme back or leg pain, and who have found no improvement with more conservative treatment options.
Titanium Clip Metal Detector to Aid Breast Surgery
This titanium metal detector localizes titanium biopsy clips placed at the site of breast tissue biopsies. The device is a handheld metal detector that can be inserted into a surgical incision to help locate small titanium markers without an invasive procedure to insert a localizing wire or radioactive seed. The device uses a two-step detection system which is initiated by running the scanning wand across the patient’s breast as a means of rapidly guiding clinicians to the marker’s general location. Once an approximate location is determined, the probing wand is used to identify the marker’s precise location. An incision is made and the probing wand guides the surgeon’s path to the marker through continuous feedback. The system relates proximity information to clinicians both through auditory feedback mechanisms and a digital display on the base.
Cooperative Therapeutic Effect of Immune Checkpoint Blockade & Anti-sMIC
The invention is a new immune-based therapy modality to treat MIC+ malignancies by the combination of a sMIC neutralizing antibody and an immune checkpoint agonist. This invention presents that a combination of sMIC antibody and anti-CTLA4 or anti-PD1/PD-L1 has superior therapeutic effect over monotherapy of individual reagents. This is a new therapeutic modality to improve the clinic response to anti-CTLA4 or anti-PD1/PD-L1 therapy.
"Ideas of March" Campaign Winner
Congratulations to John Lemasters (MD/PhD), Eduardo Maldonado (PhD), and David DeHart for winning the "Ideas of March" campaign. Their invention focuses on the creation of new small molecules to serve as new potential chemotherapeutics that either inhibit glycolysis or promote mitochondrial metabolism to cause tumor cell death.
Medical Innovation Interest Group
Dr. Nancy DeMore, 4 medical students (Ryan Gedney, Matt Hapstack, Alex Cocca, & Elliot Calvert), and MUSC FRD have worked together to create a medical innovation interest group intended to educate medical students on various aspects of inventing new ideas and being physician entrepreneurs. The group will officially get under way in August, 2017. The group will gather monthly, and the students will hear talks on topics ranging from how to write a business plan, how to take a medical device to market, intellectual property, and testimonials from physician entrepreneurs.
If you are interested in learning more about how you can contribute, please email Chelsea Ex-Lubeskie.
National Academy of Inventors, MUSC recognize new fellow
Charleston, S.C. (Feb. 8, 2017)
–Craig Beeson, Ph.D., Medical University of South Carolina College of Pharmacy professor and metabolics core director, has been named a fellow of the National Academy of Inventors (NAI). Election to NAI fellows status is a high professional distinction accorded to academic inventors who have demonstrated a prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development, and the welfare of society. The 2016 fellows will be inducted on April 6, 2017, as part of the Sixth Annual Conference of the National Academy of Inventors at the John F. Kennedy Presidential Library and Museum in Boston, MA.